1ktg - Revision history

OCA at 09:04, 16 August 2023

2023-08-16T09:04:34Z

←Older revision		Revision as of 09:04, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1ktg' size='340' side='right'caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ktg' size='340' side='right'caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1kt9\|1kt9]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">Y37H9A.6 ([http~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [https://pdbe.org/1ktg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [https://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [~~http~~://pdbe.org/1ktg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AP4A_CAEEL AP4A_CAEEL]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.<ref>PMID:11738085</ref>	+	[https://www.uniprot.org/uniprot/AP4A_CAEEL AP4A_CAEEL] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.<ref>PMID:11738085</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel~~]]	+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abdelghany~~, H M~~]]	+	[[Category: Abdelghany HM]]
-	[[Category: Bailey, S]]	+	[[Category: Bailey S]]
-	[[Category: Baker~~, P J~~]]	+	[[Category: Baker PJ]]
-	[[Category: Blackburn~~, G M~~]]	+	[[Category: Blackburn GM]]
-	[[Category: McLennan~~, A G~~]]	+	[[Category: McLennan AG]]
-	[[Category: Rafferty~~, J B~~]]	+	[[Category: Rafferty JB]]
-	[[Category: Sedelnikova~~, S E]]~~	+	[[Category: Sedelnikova SE]]
-	~~[[Category: Amp]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Magnesium cluster]]~~	+
-	~~[[Category: Nudix~~]]	+

OCA at 07:50, 25 November 2020

2020-11-25T07:50:01Z

←Older revision		Revision as of 07:50, 25 November 2020
Line 1:		Line 1:

	==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==		==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==
-	<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ktg' size='340' side='right'caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kt9\|1kt9]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://pdbe.org/1ktg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://pdbe.org/1ktg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Caeel]]		[[Category: Caeel]]
		+	[[Category: Large Structures]]
	[[Category: Abdelghany, H M]]		[[Category: Abdelghany, H M]]
	[[Category: Bailey, S]]		[[Category: Bailey, S]]

OCA at 07:32, 11 October 2017

2017-10-11T07:32:13Z

←Older revision		Revision as of 07:32, 11 October 2017
Line 1:		Line 1:
		+
	==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==		==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==
	<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://pdbe.org/1ktg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://pdbe.org/1ktg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:26, 11 September 2015

2015-09-11T11:26:23Z

←Older revision		Revision as of 11:26, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caenorhabditis_elegans Caenorhabditis elegans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 ~~Caenorhabditis elegans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://pdbe.org/1ktg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ktg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caenorhabditis elegans~~]]	+	[[Category: Caeel]]
	[[Category: Abdelghany, H M]]		[[Category: Abdelghany, H M]]
	[[Category: Bailey, S]]		[[Category: Bailey, S]]

OCA at 15:49, 25 December 2014

2014-12-25T15:49:14Z

←Older revision		Revision as of 15:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KTG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AP4A_CAEEL AP4A_CAEEL]] Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.<ref>PMID:11738085</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Abdelghany, H M.]]	+	[[Category: Abdelghany, H M]]
-	[[Category: Bailey, S.]]	+	[[Category: Bailey, S]]
-	[[Category: Baker, P J.]]	+	[[Category: Baker, P J]]
-	[[Category: Blackburn, G M.]]	+	[[Category: Blackburn, G M]]
-	[[Category: McLennan, A G.]]	+	[[Category: McLennan, A G]]
-	[[Category: Rafferty, J B.]]	+	[[Category: Rafferty, J B]]
-	[[Category: Sedelnikova, S E.]]	+	[[Category: Sedelnikova, S E]]
	[[Category: Amp]]		[[Category: Amp]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Magnesium cluster]]		[[Category: Magnesium cluster]]
	[[Category: Nudix]]		[[Category: Nudix]]

OCA at 13:51, 28 September 2014

2014-09-28T13:51:36Z

←Older revision		Revision as of 13:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ktg.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex==
		+	<StructureSection load='1ktg' size='340' side='right' caption='[[1ktg]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KTG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kt9\|1kt9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/1ktg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.

-	~~{{STRUCTURE_1ktg\| PDB=1ktg \| SCENE= }}~~	+	The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.,Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB Structure. 2002 Apr;10(4):589-600. PMID:11937063<ref>PMID:11937063</ref>

-	~~===Crystal Structure~~ of ~~a C~~. ~~elegans Ap4A Hydrolase Binary Complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11937063}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ktg]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:011937063<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Abdelghany, H M.]]		[[Category: Abdelghany, H M.]]

OCA: Protected "1ktg" [edit=sysop:move=sysop]

2012-12-05T20:58:51Z

Protected "1ktg" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:58, 5 December 2012

OCA at 20:58, 5 December 2012

2012-12-05T20:58:47Z

←Older revision		Revision as of 20:58, 5 December 2012
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-	{{Seed}}
	[[Image:1ktg.png\|left\|200px]]		[[Image:1ktg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ktg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ktg\| PDB=1ktg \| SCENE= }}		{{STRUCTURE_1ktg\| PDB=1ktg \| SCENE= }}

	===Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex===		===Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11937063}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11937063 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11937063}}		{{ABSTRACT_PUBMED_11937063}}

	==About this Structure==		==About this Structure==
-	~~1KTG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].	+	[[1ktg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11937063~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011937063</ref><references group="xtra"/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Abdelghany, H M.]]		[[Category: Abdelghany, H M.]]
Line 33:		Line 21:
	[[Category: Sedelnikova, S E.]]		[[Category: Sedelnikova, S E.]]
	[[Category: Amp]]		[[Category: Amp]]
		+	[[Category: Hydrolase]]
	[[Category: Magnesium cluster]]		[[Category: Magnesium cluster]]
	[[Category: Nudix]]		[[Category: Nudix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:55:03 2009''

OCA at 18:55, 17 February 2009

2009-02-17T18:55:04Z

←Older revision		Revision as of 18:55, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1KTG is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].	+	1KTG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTG OCA].

	==Reference==		==Reference==
-	The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/11937063 11937063]~~	+	<ref group="xtra">PMID:11937063</ref><references group="xtra"/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Single protein]]
	[[Category: Abdelghany, H M.]]		[[Category: Abdelghany, H M.]]
	[[Category: Bailey, S.]]		[[Category: Bailey, S.]]
Line 37:		Line 36:
	[[Category: Nudix]]		[[Category: Nudix]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 10~~:57:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:55:03 2009''

OCA at 07:57, 2 July 2008

2008-07-02T07:57:56Z

←Older revision		Revision as of 07:57, 2 July 2008
Line 1:		Line 1:
-	[[Image:1ktg.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1ktg.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1ktg\| PDB=1ktg \| SCENE= }}		{{STRUCTURE_1ktg\| PDB=1ktg \| SCENE= }}

-	~~'''~~Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex~~'''~~	+	===Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex===


-	~~==Overview==~~	+	<!--
-	The ~~crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A~~, ~~respectively. Ap(4)A hydrolase has a key role in regulating~~ the ~~intracellular Ap(4)A levels and hence potentially the cellular response~~ to ~~metabolic stress and/or differentiation and apoptosis via~~ the Ap(~~3)A~~/~~Ap(4)A ratio~~. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. ~~These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate~~, ~~but not triphosphate, compounds through precise orientation of key elements of~~ the ~~substrate~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_11937063}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 11937063 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_11937063}}

	==About this Structure==		==About this Structure==
Line 32:		Line 36:
	[[Category: Magnesium cluster]]		[[Category: Magnesium cluster]]
	[[Category: Nudix]]		[[Category: Nudix]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 23:09:06 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:57:52 2008''