1kv6 - Revision history

OCA at 09:05, 16 August 2023

2023-08-16T09:05:08Z

←Older revision		Revision as of 09:05, 16 August 2023
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	<StructureSection load='1kv6' size='340' side='right'caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kv6' size='340' side='right'caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NR3B3 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [https://pdbe.org/1kv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kv6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [~~http~~://pdbe.org/1kv6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kv6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kv6 ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref> [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref> <ref>PMID:7481822</ref> <ref>PMID:9223431</ref> <ref>PMID:9296499</ref> <ref>PMID:9223281</ref> <ref>PMID:10449719</ref> <ref>PMID:12954634</ref>	+	[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourguet, W]]	+	[[Category: Bourguet W]]
-	~~[[Category: Dorsselaer, A van~~]]	+	[[Category: Greschik H]]
-	[[Category: Greschik, H]]	+	[[Category: Moras D]]
-	[[Category: Moras, D]]	+	[[Category: Renaud J-P]]
-	[[Category: Renaud, J P]]	+	[[Category: Sanglier S]]
-	~~[[Category: SPINE, Structural Proteomics in Europe~~]]	+	[[Category: Wurtz J-M]]
-	[[Category: Sanglier, S]]	+	[[Category: Van Dorsselaer A]]
-	[[Category: Wurtz, J M]]	+
-	[[Category: ~~Gene regulation]]~~	+
-	~~[[Category: Spine]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Structural proteomics in europe]]~~	+
-	~~[[Category: Transcriptionally active conformation in absence of ligand~~]]	+

OCA at 07:50, 25 November 2020

2020-11-25T07:50:43Z

←Older revision		Revision as of 07:50, 25 November 2020
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	==X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation==		==X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation==
-	<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='1kv6' size='340' side='right'caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://pdbe.org/1kv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kv6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://pdbe.org/1kv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kv6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kv6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kv6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1kv6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kv6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen-related receptor 3D structures\|Estrogen-related receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bourguet, W]]		[[Category: Bourguet, W]]
	[[Category: Dorsselaer, A van]]		[[Category: Dorsselaer, A van]]

OCA at 07:28, 11 October 2017

2017-10-11T07:28:04Z

←Older revision		Revision as of 07:28, 11 October 2017
Line 1:		Line 1:
		+
	==X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation==		==X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation==
	<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://pdbe.org/1kv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://pdbe.org/1kv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kv6 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kv6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 1kv6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1kv6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Estrogen-related receptor\|Estrogen-related receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:38, 12 September 2015

2015-09-12T02:38:28Z

←Older revision		Revision as of 02:38, 12 September 2015
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	<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://pdbe.org/1kv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kv6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bourguet, W]]		[[Category: Bourguet, W]]
	[[Category: Dorsselaer, A van]]		[[Category: Dorsselaer, A van]]

OCA at 17:05, 5 January 2015

2015-01-05T17:05:27Z

←Older revision		Revision as of 17:05, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.		[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bourguet, W.]]	+	[[Category: Bourguet, W]]
-	[[Category: Dorsselaer, A van.]]	+	[[Category: Dorsselaer, A van]]
-	[[Category: Greschik, H.]]	+	[[Category: Greschik, H]]
-	[[Category: Moras, D.]]	+	[[Category: Moras, D]]
-	[[Category: Renaud, J P.]]	+	[[Category: Renaud, J P]]
-	[[Category: SPINE, Structural Proteomics in Europe.]]	+	[[Category: SPINE, Structural Proteomics in Europe]]
-	[[Category: Sanglier, S.]]	+	[[Category: Sanglier, S]]
-	[[Category: Wurtz, J M.]]	+	[[Category: Wurtz, J M]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
	[[Category: Spine]]		[[Category: Spine]]

OCA at 17:36, 29 September 2014

2014-09-29T17:36:32Z

←Older revision		Revision as of 17:36, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1kv6\| PDB=1kv6 \| SCENE= }}~~	+	==X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation==
-	===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===	+	<StructureSection load='1kv6' size='340' side='right' caption='[[1kv6]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_11864604}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV6 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ere\|1ere]], [[3erd\|3erd]], [[1k4w\|1k4w]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv6 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.		[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref> [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref> <ref>PMID:7481822</ref> <ref>PMID:9223431</ref> <ref>PMID:9296499</ref> <ref>PMID:9223281</ref> <ref>PMID:10449719</ref> <ref>PMID:12954634</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kv6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the ligand binding domain (LBD) of the estrogen-related receptor 3 (ERR3) complexed with a steroid receptor coactivator-1 (SRC-1) peptide reveals a transcriptionally active conformation in absence of any ligand. The structure explains why estradiol does not bind ERRs with significant affinity. Docking of the previously reported ERR antagonists, diethylstilbestrol and 4-hydroxytamoxifen, requires structural rearrangements enlarging the ligand binding pocket that can only be accommodated with an antagonist LBD conformation. Mutant receptors in which the ligand binding cavity is filled up by bulkier side chains still interact with SRC-1 in vitro and are transcriptionally active in vivo, but are no longer efficiently inactivated by diethylstilbestrol or 4-hydroxytamoxifen. These results provide structural and functional evidence for ligand-independent transcriptional activation by ERR3.

-	~~==Function==~~	+	Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.,Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP Mol Cell. 2002 Feb;9(2):303-13. PMID:11864604<ref>PMID:11864604</ref>
-	~~[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound~~ ligand~~. Binds specifically to an estrogen response element and activates reporter genes controlled~~ by estrogen ~~response elements (By similarity).<ref>PMID:19067653</ref><ref>PMID:18063693</ref><ref>PMID:11864604</ref> [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear~~ receptor ~~coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion~~. ~~Involved in the coactivation of different nuclear receptors~~, ~~such as for steroids (PGR~~, ~~GR and ER)~~, ~~retinoids (RXRs)~~, ~~thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3~~, ~~STAT5A~~, ~~STAT5B and STAT6 transcription factors~~. ~~Displays histone acetyltransferase activity toward H3 and H4~~; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 ~~has a higher thyroid hormone~~-~~dependent transactivation activity than isoform 1 and isoform 3~~.~~<ref>~~PMID:~~9427757</ref>~~<ref>PMID:~~7481822</ref><ref>PMID:9223431</ref><ref>PMID:9296499</ref><ref>PMID:9223281</ref><ref>PMID:10449719</ref><ref>PMID:12954634~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1kv6]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Estrogen-related receptor\|Estrogen-related receptor]]		*[[Estrogen-related receptor\|Estrogen-related receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:011864604</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourguet, W.]]		[[Category: Bourguet, W.]]

OCA at 07:16, 25 March 2013

2013-03-25T07:16:37Z

←Older revision		Revision as of 07:16, 25 March 2013
Line 2:		Line 2:
	===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===		===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===
	{{ABSTRACT_PUBMED_11864604}}		{{ABSTRACT_PUBMED_11864604}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref><ref>PMID:18063693</ref><ref>PMID:11864604</ref> [[http://www.uniprot.org/uniprot/NCOA1_HUMAN NCOA1_HUMAN]] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:9427757</ref><ref>PMID:7481822</ref><ref>PMID:9223431</ref><ref>PMID:9296499</ref><ref>PMID:9223281</ref><ref>PMID:10449719</ref><ref>PMID:12954634</ref>

	==About this Structure==		==About this Structure==
Line 10:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:011864604</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011864604</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourguet, W.]]		[[Category: Bourguet, W.]]

OCA at 11:12, 11 March 2013

2013-03-11T11:12:31Z

←Older revision		Revision as of 11:12, 11 March 2013
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-	[[Image:1kv6.png\|left\|200px]]
-
	{{STRUCTURE_1kv6\| PDB=1kv6 \| SCENE= }}		{{STRUCTURE_1kv6\| PDB=1kv6 \| SCENE= }}
-
	===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===		===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===
-
	{{ABSTRACT_PUBMED_11864604}}		{{ABSTRACT_PUBMED_11864604}}

OCA: Protected "1kv6" [edit=sysop:move=sysop]

2012-12-05T21:23:06Z

Protected "1kv6" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:23, 5 December 2012

OCA at 21:23, 5 December 2012

2012-12-05T21:23:03Z

←Older revision		Revision as of 21:23, 5 December 2012
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-	{{Seed}}
	[[Image:1kv6.png\|left\|200px]]		[[Image:1kv6.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1kv6\| PDB=1kv6 \| SCENE= }}		{{STRUCTURE_1kv6\| PDB=1kv6 \| SCENE= }}

	===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===		===X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11864604}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11864604 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_11864604}}		{{ABSTRACT_PUBMED_11864604}}

	==About this Structure==		==About this Structure==
-	~~1KV6~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA].	+	[[1kv6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV6 OCA].
		+
		+	==See Also==
		+	*[[Estrogen-related receptor\|Estrogen-related receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11864604~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011864604</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourguet, W.]]		[[Category: Bourguet, W.]]
Line 33:		Line 24:
	[[Category: Sanglier, S.]]		[[Category: Sanglier, S.]]
	[[Category: Wurtz, J M.]]		[[Category: Wurtz, J M.]]
		+	[[Category: Gene regulation]]
	[[Category: Spine]]		[[Category: Spine]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural proteomics in europe]]		[[Category: Structural proteomics in europe]]
	[[Category: Transcriptionally active conformation in absence of ligand]]		[[Category: Transcriptionally active conformation in absence of ligand]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:09:13 2009''