1kvz - Revision history

OCA at 09:43, 21 December 2022

2022-12-21T09:43:18Z

←Older revision		Revision as of 09:43, 21 December 2022
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	==Solution Structure of Cytotoxic RC-RNase4==		==Solution Structure of Cytotoxic RC-RNase4==
-	<StructureSection load='1kvz' size='340' side='right'caption='[[1kvz~~]], [[NMR_Ensembles_of_Models \| 15 NMR models~~]]' scene=''>	+	<StructureSection load='1kvz' size='340' side='right'caption='[[1kvz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~American_bullfrog American bullfrog~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [https://pdbe.org/1kvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [https://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [https://pdbe.org/1kvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [https://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9DFY6_LITCT Q9DFY6_LITCT]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: American bullfrog]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, C]]	+	[[Category: Lithobates catesbeianus]]
-	[[Category: Chen, L W]]	+	[[Category: Chen C]]
-	[[Category: Hsu, C H]]	+	[[Category: Chen L-W]]
-	[[Category: Liao, Y D]]	+	[[Category: Hsu C-H]]
-	[[Category: Wu, S H]]	+	[[Category: Liao Y-D]]
-	~~[[Category: Antitumor]]~~	+	[[Category: Wu S-H]]
-	~~[[Category: Bullfrog]]~~	+
-	~~[[Category: Cytotoxicity]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ribonuclease]]~~	+
-	~~[[Category: Structure from molmol~~]]	+

OCA at 08:11, 23 February 2022

2022-02-23T08:11:16Z

←Older revision		Revision as of 08:11, 23 February 2022
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	<StructureSection load='1kvz' size='340' side='right'caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1kvz' size='340' side='right'caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [~~http~~://pdbe.org/1kvz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [https://pdbe.org/1kvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [https://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	==See Also==		==See Also==
	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]		*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	*[[Temp\|Temp]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 25 November 2020

2020-11-25T07:51:01Z

←Older revision		Revision as of 07:51, 25 November 2020
Line 1:		Line 1:

	==Solution Structure of Cytotoxic RC-RNase4==		==Solution Structure of Cytotoxic RC-RNase4==
-	<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>	+	<StructureSection load='1kvz' size='340' side='right'caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://pdbe.org/1kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://pdbe.org/1kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: American bullfrog]]		[[Category: American bullfrog]]
		+	[[Category: Large Structures]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Chen, L W]]		[[Category: Chen, L W]]

OCA at 21:20, 24 January 2018

2018-01-24T21:20:53Z

←Older revision		Revision as of 21:20, 24 January 2018
Line 1:		Line 1:
		+
	==Solution Structure of Cytotoxic RC-RNase4==		==Solution Structure of Cytotoxic RC-RNase4==
	<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://pdbe.org/1kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://pdbe.org/1kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kvz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kvz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kvz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
	== References ==		== References ==

OCA at 07:43, 10 February 2016

2016-02-10T07:43:12Z

←Older revision		Revision as of 07:43, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kvz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:48, 11 September 2015

2015-09-11T06:48:09Z

←Older revision		Revision as of 06:48, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>		<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rana_catesbeiana Rana catesbeiana~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/American_bullfrog American bullfrog]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 ~~Rana catesbeiana~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 American bullfrog])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://pdbe.org/1kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1kvz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
	*[[Temp\|Temp]]		*[[Temp\|Temp]]
-	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rana catesbeiana~~]]	+	[[Category: American bullfrog]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Chen, L W]]		[[Category: Chen, L W]]

OCA at 16:31, 5 January 2015

2015-01-05T16:31:16Z

←Older revision		Revision as of 16:31, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 Rana catesbeiana])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 Rana catesbeiana])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
		+	*[[Temp\|Temp]]
		+	*[[User:Jaime.Prilusky/Test/tree\|User:Jaime.Prilusky/Test/tree]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Rana catesbeiana]]		[[Category: Rana catesbeiana]]
-	[[Category: Chen, C.]]	+	[[Category: Chen, C]]
-	[[Category: Chen, L W.]]	+	[[Category: Chen, L W]]
-	[[Category: Hsu, C H.]]	+	[[Category: Hsu, C H]]
-	[[Category: Liao, Y D.]]	+	[[Category: Liao, Y D]]
-	[[Category: Wu, S H.]]	+	[[Category: Wu, S H]]
	[[Category: Antitumor]]		[[Category: Antitumor]]
	[[Category: Bullfrog]]		[[Category: Bullfrog]]

OCA at 14:56, 28 September 2014

2014-09-28T14:56:40Z

←Older revision		Revision as of 14:56, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1kvz.~~png\|left~~\|200px]]	+	==Solution Structure of Cytotoxic RC-RNase4==
		+	<StructureSection load='1kvz' size='340' side='right' caption='[[1kvz]], [[NMR_Ensembles_of_Models \| 15 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KVZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Oocytes ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8400 Rana catesbeiana])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kvz RCSB], [http://www.ebi.ac.uk/pdbsum/1kvz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/1kvz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytotoxic ribonucleases with antitumor activity are mainly found in the oocytes and early embryos of frogs. Native RC-RNase 4 (RNase 4), consisting of 106 residues linked with four disulfide bridges, is a cytotoxic ribonuclease isolated from oocytes of bullfrog Rana catesbeiana. RNase 4 belongs to the bovine pancreatic ribonuclease (RNase A) superfamily. Recombinant RC-RNase 4 (rRNase 4), which contains an additional Met residue and glutamine instead of pyroglutamate at the N terminus, was found to possess less catalytic and cytotoxic activities than RNase 4. Equilibrium thermal and guanidine-HCl denaturation CD measurements revealed that RNase 4 is more thermally and chemically stable than rRNase 4. However, CD and NMR data showed that there is no gross conformational change between native and recombinant RNase 4. The NMR solution structure of rRNase 4 was determined to comprise three alpha-helices and two sets of antiparallel beta-sheets. Superimposition of each structure with the mean structure yielded an average root mean square deviation (RMSD) of 0.72(+/-0.14)A for the backbone atoms, and 1.42(+/-0.19)A for the heavy atoms in residues 3-105. A comparison of the 3D structure of rRNase 4 with the structurally and functionally related cytotoxic ribonuclease, onconase (ONC), showed that the two H-bonds in the N-terminal pyroglutamate of ONC were not present at the corresponding glutamine residue of rRNase 4. We suggest that the loss of these two H-bonds is one of the key factors responsible for the reductions of the conformational stability, catalytic and cytotoxic activities in rRNase 4. Furthermore, the differences of side-chain conformations of subsite residues among RNase A, ONC and rRNase 4 are related to their distinct catalytic activities and base preferences.

-	~~{{STRUCTURE_1kvz\| PDB=1kvz \| SCENE= }}~~	+	Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.,Hsu CH, Liao YD, Pan YR, Chen LW, Wu SH, Leu YJ, Chen C J Mol Biol. 2003 Feb 28;326(4):1189-201. PMID:12589762<ref>PMID:12589762</ref>

-	~~===Solution Structure~~ of ~~Cytotoxic RC-RNase4===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12589762}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1kvz]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rana_catesbeiana Rana catesbeiana]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA].~~	+

	==See Also==		==See Also==
	*[[Ribonuclease\|Ribonuclease]]		*[[Ribonuclease\|Ribonuclease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012589762<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rana catesbeiana]]		[[Category: Rana catesbeiana]]
	[[Category: Chen, C.]]		[[Category: Chen, C.]]

OCA at 16:50, 20 October 2012

2012-10-20T16:50:55Z

←Older revision		Revision as of 16:50, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1kvz]] is a 1 chain structure ~~of [[Ribonuclease]]~~ with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA].	+	[[1kvz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KVZ OCA].

	==See Also==		==See Also==

OCA: Protected "1kvz" [edit=sysop:move=sysop]

2012-07-26T23:01:06Z

Protected "1kvz" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:01, 26 July 2012