1l26 - Revision history

OCA at 10:17, 24 November 2022

2022-11-24T10:17:44Z

←Older revision		Revision as of 10:17, 24 November 2022
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	<StructureSection load='1l26' size='340' side='right'caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1l26' size='340' side='right'caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpt4 Bpt4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [https://pdbe.org/1l26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [https://www.ebi.ac.uk/pdbsum/1l26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l26 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [https://pdbe.org/1l26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [https://www.ebi.ac.uk/pdbsum/1l26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l26 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LYS_BPT4 LYS_BPT4~~]~~] Helps~~ to ~~release~~ the mature ~~phage~~ particles ~~from~~ the cell ~~wall by breaking~~ down the peptidoglycan.	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bpt4~~]]	+	[[Category: Escherichia virus T4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Bell JA]]
-	[[Category: Bell~~, J A~~]]	+	[[Category: Dao-Pin S]]
-	[[Category: Dao-Pin, S]]	+	[[Category: Matthews BW]]
-	[[Category: Matthews~~, B W~~]]	+

OCA at 06:38, 18 August 2021

2021-08-18T06:38:33Z

←Older revision		Revision as of 06:38, 18 August 2021
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	<StructureSection load='1l26' size='340' side='right'caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1l26' size='340' side='right'caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [~~http~~://pdbe.org/1l26 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l26 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l26 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [https://pdbe.org/1l26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [https://www.ebi.ac.uk/pdbsum/1l26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l26 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.	+	[[https://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:21, 13 November 2019

2019-11-13T12:21:51Z

←Older revision		Revision as of 12:21, 13 November 2019
Line 1:		Line 1:

	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==		==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
-	<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='1l26' size='340' side='right'caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l26_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l26_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bpt4]]		[[Category: Bpt4]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Bell, J A]]		[[Category: Bell, J A]]
	[[Category: Dao-Pin, S]]		[[Category: Dao-Pin, S]]
	[[Category: Matthews, B W]]		[[Category: Matthews, B W]]

OCA at 10:31, 18 October 2017

2017-10-18T10:31:47Z

←Older revision		Revision as of 10:31, 18 October 2017
Line 1:		Line 1:
		+
	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==		==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
	<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://pdbe.org/1l26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://pdbe.org/1l26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l26 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l26 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:51, 11 September 2015

2015-09-11T16:51:45Z

←Older revision		Revision as of 16:51, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_t4 Enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://pdbe.org/1l26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l26" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage t4~~]]	+	[[Category: Bpt4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Bell, J A]]		[[Category: Bell, J A]]
	[[Category: Dao-Pin, S]]		[[Category: Dao-Pin, S]]
	[[Category: Matthews, B W]]		[[Category: Matthews, B W]]

OCA at 19:15, 25 December 2014

2014-12-25T19:15:10Z

←Older revision		Revision as of 19:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: Bell, J A.]]	+	[[Category: Bell, J A]]
-	[[Category: Dao-Pin, S.]]	+	[[Category: Dao-Pin, S]]
-	[[Category: Matthews, B W.]]	+	[[Category: Matthews, B W]]

OCA at 13:20, 28 September 2014

2014-09-28T13:20:09Z

←Older revision		Revision as of 13:20, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1l26.~~png~~\|~~left~~\|200px]]	+	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
		+	<StructureSection load='1l26' size='340' side='right' caption='[[1l26]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L26 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l27\|1l27]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l26 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l26 RCSB], [http://www.ebi.ac.uk/pdbsum/1l26 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l26_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue Pro86 in an alpha-helix in phage T4 lysozyme was replaced by ten different amino acids. The x-ray crystal structures of seven of the mutant lysozymes were determined at high resolution. In each case, replacement of the proline resulted in the formation of an extended alpha-helix. This involves a large conformational change in residues 81 to 83 and smaller shifts that extend 20 angstroms across the protein surface. Unexpectedly, all ten amino acid substitutions marginally reduce protein thermostability. This insensitivity of stability to the amino acid at position 86 is not simply explained by statistical and thermodynamic criteria for helical propensity. The observed conformational changes illustrate a general mechanism by which proteins can tolerate mutations.

-	~~{{STRUCTURE_1l26\| PDB=1l26 \| SCENE= }}~~	+	Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability.,Alber T, Bell JA, Sun DP, Nicholson H, Wozniak JA, Cook S, Matthews BW Science. 1988 Feb 5;239(4840):631-5. PMID:3277275<ref>PMID:3277275</ref>

-	~~===REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_3277275}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1l26]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:003277275<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 20:26, 20 October 2012

2012-10-20T20:26:32Z

←Older revision		Revision as of 20:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1l26]] is a 1 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA].	+	[[1l26]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA].

	==See Also==		==See Also==

OCA: Protected "1l26" [edit=sysop:move=sysop]

2012-07-27T10:30:06Z

Protected "1l26" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:30, 27 July 2012

OCA at 10:30, 27 July 2012

2012-07-27T10:30:03Z

←Older revision		Revision as of 10:30, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1l26.png\|left\|200px]]		[[Image:1l26.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1l26", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1l26\| PDB=1l26 \| SCENE= }}		{{STRUCTURE_1l26\| PDB=1l26 \| SCENE= }}

	===REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY===		===REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_3277275}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 3277275 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_3277275}}		{{ABSTRACT_PUBMED_3277275}}

	==About this Structure==		==About this Structure==
-	~~1L26~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA].	+	[[1l26]] is a 1 chain structure of [[Hen Egg-White (HEW) Lysozyme]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L26 OCA].
		+
		+	==See Also==
		+	*[[Hen Egg-White (HEW) Lysozyme\|Hen Egg-White (HEW) Lysozyme]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~3277275~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:003277275</ref><references group="xtra"/>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
Line 29:		Line 20:
	[[Category: Dao-Pin, S.]]		[[Category: Dao-Pin, S.]]
	[[Category: Matthews, B W.]]		[[Category: Matthews, B W.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 08:42:00 2010''