1l27 - Revision history

OCA at 08:44, 22 May 2024

2024-05-22T08:44:48Z

←Older revision		Revision as of 08:44, 22 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [https://pdbe.org/1l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [https://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [https://pdbe.org/1l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [https://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:17, 24 November 2022

2022-11-24T10:17:46Z

←Older revision		Revision as of 10:17, 24 November 2022
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	<StructureSection load='1l27' size='340' side='right'caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1l27' size='340' side='right'caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpt4 Bpt4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [https://pdbe.org/1l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [https://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [https://pdbe.org/1l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [https://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~LYS_BPT4 LYS_BPT4~~]~~] Helps~~ to ~~release~~ the mature ~~phage~~ particles ~~from~~ the cell ~~wall by breaking~~ down the peptidoglycan.	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bpt4~~]]	+	[[Category: Escherichia virus T4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Bell JA]]
-	[[Category: Bell~~, J A~~]]	+	[[Category: Dao-Pin S]]
-	[[Category: Dao-Pin, S]]	+	[[Category: Matthews BW]]
-	[[Category: Matthews~~, B W~~]]	+

OCA at 06:38, 18 August 2021

2021-08-18T06:38:35Z

←Older revision		Revision as of 06:38, 18 August 2021
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	<StructureSection load='1l27' size='340' side='right'caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1l27' size='340' side='right'caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1L27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [~~http~~://pdbe.org/1l27 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [https://pdbe.org/1l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [https://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.	+	[[https://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:28, 13 November 2019

2019-11-13T12:28:04Z

←Older revision		Revision as of 12:28, 13 November 2019
Line 1:		Line 1:

	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==		==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
-	<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1l27' size='340' side='right'caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l27_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l27_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Bpt4]]		[[Category: Bpt4]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Bell, J A]]		[[Category: Bell, J A]]
	[[Category: Dao-Pin, S]]		[[Category: Dao-Pin, S]]
	[[Category: Matthews, B W]]		[[Category: Matthews, B W]]

OCA at 06:41, 29 November 2017

2017-11-29T06:41:56Z

←Older revision		Revision as of 06:41, 29 November 2017
Line 1:		Line 1:
		+
	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==		==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
	<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://pdbe.org/1l27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://pdbe.org/1l27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:48, 8 February 2016

2016-02-08T11:48:16Z

←Older revision		Revision as of 11:48, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l27 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:16, 10 September 2015

2015-09-10T11:16:32Z

←Older revision		Revision as of 11:16, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacteria_phage_t4 Enterobacteria phage t4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://pdbe.org/1l27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1l27" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Enterobacteria phage t4~~]]	+	[[Category: Bpt4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Bell, J A]]		[[Category: Bell, J A]]
	[[Category: Dao-Pin, S]]		[[Category: Dao-Pin, S]]
	[[Category: Matthews, B W]]		[[Category: Matthews, B W]]

OCA at 23:05, 24 December 2014

2014-12-24T23:05:43Z

←Older revision		Revision as of 23:05, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYS_BPT4 LYS_BPT4]] Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
-	[[Category: Bell, J A.]]	+	[[Category: Bell, J A]]
-	[[Category: Dao-Pin, S.]]	+	[[Category: Dao-Pin, S]]
-	[[Category: Matthews, B W.]]	+	[[Category: Matthews, B W]]

OCA at 13:59, 28 September 2014

2014-09-28T13:59:00Z

←Older revision		Revision as of 13:59, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1l27.~~png~~\|~~left~~\|200px]]	+	==REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY==
		+	<StructureSection load='1l27' size='340' side='right' caption='[[1l27]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L27 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2lzm\|2lzm]], [[1l01\|1l01]], [[1l02\|1l02]], [[1l03\|1l03]], [[1l04\|1l04]], [[1l05\|1l05]], [[1l06\|1l06]], [[1l07\|1l07]], [[1l08\|1l08]], [[1l09\|1l09]], [[1l10\|1l10]], [[1l11\|1l11]], [[1l12\|1l12]], [[1l13\|1l13]], [[1l14\|1l14]], [[1l15\|1l15]], [[1l16\|1l16]], [[1l17\|1l17]], [[1l18\|1l18]], [[1l19\|1l19]], [[1l20\|1l20]], [[1l21\|1l21]], [[1l22\|1l22]], [[1l23\|1l23]], [[1l24\|1l24]], [[1l25\|1l25]], [[1l26\|1l26]], [[1l28\|1l28]], [[1l29\|1l29]], [[1l30\|1l30]], [[1l31\|1l31]], [[1l32\|1l32]], [[1l33\|1l33]], [[1l34\|1l34]], [[1l35\|1l35]], [[1l36\|1l36]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1l27 RCSB], [http://www.ebi.ac.uk/pdbsum/1l27 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l27_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue Pro86 in an alpha-helix in phage T4 lysozyme was replaced by ten different amino acids. The x-ray crystal structures of seven of the mutant lysozymes were determined at high resolution. In each case, replacement of the proline resulted in the formation of an extended alpha-helix. This involves a large conformational change in residues 81 to 83 and smaller shifts that extend 20 angstroms across the protein surface. Unexpectedly, all ten amino acid substitutions marginally reduce protein thermostability. This insensitivity of stability to the amino acid at position 86 is not simply explained by statistical and thermodynamic criteria for helical propensity. The observed conformational changes illustrate a general mechanism by which proteins can tolerate mutations.

-	~~{{STRUCTURE_1l27\| PDB=1l27 \| SCENE= }}~~	+	Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability.,Alber T, Bell JA, Sun DP, Nicholson H, Wozniak JA, Cook S, Matthews BW Science. 1988 Feb 5;239(4840):631-5. PMID:3277275<ref>PMID:3277275</ref>

-	~~===REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_3277275}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1l27]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA].~~	+

	==See Also==		==See Also==
-	*[[~~Hen Egg-White (HEW)~~ Lysozyme\|~~Hen Egg-White (HEW)~~ Lysozyme]]	+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:003277275<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]

OCA at 10:02, 20 October 2012

2012-10-20T10:02:17Z

←Older revision		Revision as of 10:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1l27]] is a 1 chain structure ~~of [[Hen Egg-White (HEW) Lysozyme]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA].	+	[[1l27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L27 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:003277275~~</ref><ref group="xtra">PMID:012426371~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:003277275</ref><references group="xtra"/>
	[[Category: Enterobacteria phage t4]]		[[Category: Enterobacteria phage t4]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]