1ll4 - Revision history

OCA at 09:15, 16 August 2023

2023-08-16T09:15:20Z

←Older revision		Revision as of 09:15, 16 August 2023
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	<StructureSection load='1ll4' size='340' side='right'caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ll4' size='340' side='right'caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cbs_120936 Cbs 120936~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>~~, ~~<scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5501 CBS 120936])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [https://pdbe.org/1ll4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ll4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll4 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [~~http~~://pdbe.org/1ll4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ll4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CHI1_COCPS CHI1_COCPS]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cbs 120936]]~~	+	[[Category: Coccidioides immitis]]
-	~~[[Category: Chitinase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bortone, K]]	+	[[Category: Bortone K]]
-	[[Category: Ernst, S]]	+	[[Category: Ernst S]]
-	[[Category: Monzingo~~, A F~~]]	+	[[Category: Monzingo AF]]
-	[[Category: Robertus~~, J D]]~~	+	[[Category: Robertus JD]]
-	~~[[Category: Beta-alpha barrel]]~~	+
-	~~[[Category: Enzyme-inhibitor complex]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:59, 25 November 2020

2020-11-25T07:59:43Z

←Older revision		Revision as of 07:59, 25 November 2020
Line 1:		Line 1:

	==STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN==		==STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN==
-	<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1ll4' size='340' side='right'caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cocit Cocit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_120936 Cbs 120936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 ~~COCIT~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 CBS 120936])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://pdbe.org/1ll4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://pdbe.org/1ll4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1ll4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ll4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Chitinase 3D structures\|Chitinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 120936]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: ~~Cocit~~]]	+	[[Category: Large Structures]]
	[[Category: Bortone, K]]		[[Category: Bortone, K]]
	[[Category: Ernst, S]]		[[Category: Ernst, S]]

OCA at 08:04, 31 January 2018

2018-01-31T08:04:09Z

←Older revision		Revision as of 08:04, 31 January 2018
Line 1:		Line 1:
		+
	==STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN==		==STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN==
	<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 COCIT])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 COCIT])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://pdbe.org/1ll4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://pdbe.org/1ll4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ll4 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/1ll4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/1ll4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1ll4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1ll4" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Chitinase\|Chitinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:11, 8 February 2016

2016-02-08T08:11:27Z

←Older revision		Revision as of 08:11, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ll4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:35, 10 September 2015

2015-09-10T09:35:09Z

←Older revision		Revision as of 09:35, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Coccidioides_immitis Coccidioides immitis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cocit Cocit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 ~~Coccidioides immitis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 COCIT])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://pdbe.org/1ll4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ll4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
-	[[Category: ~~Coccidioides immitis~~]]	+	[[Category: Cocit]]
	[[Category: Bortone, K]]		[[Category: Bortone, K]]
	[[Category: Ernst, S]]		[[Category: Ernst, S]]

OCA at 16:55, 5 January 2015

2015-01-05T16:55:03Z

←Older revision		Revision as of 16:55, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 Coccidioides immitis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 Coccidioides immitis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Coccidioides immitis]]		[[Category: Coccidioides immitis]]
-	[[Category: Bortone, K.]]	+	[[Category: Bortone, K]]
-	[[Category: Ernst, S.]]	+	[[Category: Ernst, S]]
-	[[Category: Monzingo, A F.]]	+	[[Category: Monzingo, A F]]
-	[[Category: Robertus, J D.]]	+	[[Category: Robertus, J D]]
	[[Category: Beta-alpha barrel]]		[[Category: Beta-alpha barrel]]
	[[Category: Enzyme-inhibitor complex]]		[[Category: Enzyme-inhibitor complex]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 18:22, 28 September 2014

2014-09-28T18:22:52Z

←Older revision		Revision as of 18:22, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ll4.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN==
		+	<StructureSection load='1ll4' size='340' side='right' caption='[[1ll4]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LL4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1d2k\|1d2k]], [[1ll6\|1ll6]], [[1ll7\|1ll7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5501 Coccidioides immitis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ll4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ll4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ll4 RCSB], [http://www.ebi.ac.uk/pdbsum/1ll4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/1ll4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Allosamidin is a known inhibitor of class 18 chitinases. We show that allosamidin is a competitive inhibitor of the fungal chitinase CiX1 from Coccidioides immitis, with a K(i) of 60 nM. We report the X-ray structure of the complex and show that upon inhibitor binding the side-chain of Asp169 rotates to form an ion pair with the oxazolinium cation. The mechanism of action is thought to involve protonation of the leaving group by Glu171 and substrate assistance by the sugar acetamido moiety to form an oxazoline-like intermediate. We converted both amino acid residues to the corresponding amide and found that each mutation effectively abolishes enzyme activity. X-ray structures show the mutant enzymes retain the basic wild-type structure and that the loss of mutant activity is due to their altered chemical properties. The high affinity of allosamidin, and its similarity to the putative reaction intermediate, suggests it is a transition state analog. This helps validate our contention that the role of Asp169 is to electrostatically stabilize the reaction transition state.

-	~~{{STRUCTURE_1ll4\| PDB=1ll4 \| SCENE= }}~~	+	The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism.,Bortone K, Monzingo AF, Ernst S, Robertus JD J Mol Biol. 2002 Jul 5;320(2):293-302. PMID:12079386<ref>PMID:12079386</ref>

-	~~===STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12079386}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1ll4]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Coccidioides_immitis Coccidioides immitis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA].~~	+

	==See Also==		==See Also==
	*[[Chitinase\|Chitinase]]		*[[Chitinase\|Chitinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012079386<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Coccidioides immitis]]		[[Category: Coccidioides immitis]]

OCA at 09:30, 20 October 2012

2012-10-20T09:30:23Z

←Older revision		Revision as of 09:30, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1ll4]] is a 4 chain structure ~~of [[Chitinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA].	+	[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA].

	==See Also==		==See Also==

OCA at 23:04, 25 July 2012

2012-07-25T23:04:50Z

←Older revision		Revision as of 23:04, 25 July 2012
Line 1:		Line 1:
	[[Image:1ll4.png\|left\|200px]]		[[Image:1ll4.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1ll4\| PDB=1ll4 \| SCENE= }}		{{STRUCTURE_1ll4\| PDB=1ll4 \| SCENE= }}

	===STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN===		===STRUCTURE OF C. IMMITIS CHITINASE 1 COMPLEXED WITH ALLOSAMIDIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12079386}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12079386 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12079386}}		{{ABSTRACT_PUBMED_12079386}}

	==About this Structure==		==About this Structure==
-	[[1ll4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA].	+	[[1ll4]] is a 4 chain structure of [[Chitinase]] with sequence from [http://en.wikipedia.org/wiki/Coccidioides_immitis Coccidioides immitis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LL4 OCA].
		+
		+	==See Also==
		+	*[[Chitinase\|Chitinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12079386~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012079386</ref><references group="xtra"/>
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Coccidioides immitis]]		[[Category: Coccidioides immitis]]
Line 29:		Line 21:
	[[Category: Monzingo, A F.]]		[[Category: Monzingo, A F.]]
	[[Category: Robertus, J D.]]		[[Category: Robertus, J D.]]
		+	[[Category: Beta-alpha barrel]]
		+	[[Category: Enzyme-inhibitor complex]]
		+	[[Category: Hydrolase]]

OCA: Protected "1ll4" [edit=sysop:move=sysop]

2011-03-16T07:27:49Z

Protected "1ll4" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 16 March 2011