1lo7 - Revision history

OCA at 09:16, 16 August 2023

2023-08-16T09:16:07Z

←Older revision		Revision as of 09:16, 16 August 2023
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	<StructureSection load='1lo7' size='340' side='right'caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lo7' size='340' side='right'caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseuc Pseuc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._CBS3 Pseudomonas sp. CBS3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=4CO:4~~-~~HYDROXYPHENACYL+COENZYME+A'>4CO</scene>~~, ~~<scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1lo8\|1lo8]], [[1lo9\|1lo9]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~72586 PSEUC])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [https://pdbe.org/1lo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo7 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase]~~, ~~with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [~~http~~://pdbe.org/1lo7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lo7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/4HBT_PSEUC 4HBT_PSEUC]] Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.<ref>PMID:1610806</ref>	+	[https://www.uniprot.org/uniprot/4HBT_PSEUC 4HBT_PSEUC] Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.<ref>PMID:1610806</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseuc~~]]	+	[[Category: Pseudomonas sp. CBS3]]
-	[[Category: Dunaway-Mariano, D]]	+	[[Category: Dunaway-Mariano D]]
-	[[Category: Holden~~, H M~~]]	+	[[Category: Holden HM]]
-	[[Category: Thoden~~, J B~~]]	+	[[Category: Thoden JB]]
-	[[Category: Zhuang, Z]]	+	[[Category: Zhuang Z]]
-	~~[[Category: Catalytic mechanism]]~~	+
-	~~[[Category: Hot dog fold]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Thioesterase~~]]	+

OCA at 08:00, 25 November 2020

2020-11-25T08:00:27Z

←Older revision		Revision as of 08:00, 25 November 2020
Line 1:		Line 1:

	==X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA==		==X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA==
-	<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1lo7' size='340' side='right'caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseuc Pseuc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseuc Pseuc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lo8\|1lo8]], [[1lo9\|1lo9]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 PSEUC])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 PSEUC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://pdbe.org/1lo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://pdbe.org/1lo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1lo7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lo7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]		[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
		+	[[Category: Large Structures]]
	[[Category: Pseuc]]		[[Category: Pseuc]]
	[[Category: Dunaway-Mariano, D]]		[[Category: Dunaway-Mariano, D]]

OCA at 08:11, 31 January 2018

2018-01-31T08:11:53Z

←Older revision		Revision as of 08:11, 31 January 2018
Line 1:		Line 1:
		+
	==X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA==		==X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA==
	<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 PSEUC])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 PSEUC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://pdbe.org/1lo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://pdbe.org/1lo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 1lo7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lo7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Thioesterase\|Thioesterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:03, 8 February 2016

2016-02-08T05:03:44Z

←Older revision		Revision as of 05:03, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lo7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:09, 10 September 2015

2015-09-10T08:09:05Z

←Older revision		Revision as of 08:09, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseuc Pseuc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 ~~Pseudomonas sp. CBS3~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 PSEUC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://pdbe.org/1lo7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lo7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]		[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
-	[[Category: ~~Pseudomonas sp. cbs3~~]]	+	[[Category: Pseuc]]
	[[Category: Dunaway-Mariano, D]]		[[Category: Dunaway-Mariano, D]]
	[[Category: Holden, H M]]		[[Category: Holden, H M]]

OCA at 20:50, 24 December 2014

2014-12-24T20:50:34Z

←Older revision		Revision as of 20:50, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 Pseudomonas sp. CBS3])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 Pseudomonas sp. CBS3])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/4HBT_PSEUC 4HBT_PSEUC]] Hydrolyzes 4-hydroxybenzoate-CoA, and to a lesser extent benzoyl-CoA and 4-chlorobenzoate-CoA. Not active against aliphatic acyl-CoA thioesters, including palmitoyl-CoA, hexanoyl-CoA and acetyl-CoA.<ref>PMID:1610806</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]		[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
	[[Category: Pseudomonas sp. cbs3]]		[[Category: Pseudomonas sp. cbs3]]
-	[[Category: Dunaway-Mariano, D.]]	+	[[Category: Dunaway-Mariano, D]]
-	[[Category: Holden, H M.]]	+	[[Category: Holden, H M]]
-	[[Category: Thoden, J B.]]	+	[[Category: Thoden, J B]]
-	[[Category: Zhuang, Z.]]	+	[[Category: Zhuang, Z]]
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]
	[[Category: Hot dog fold]]		[[Category: Hot dog fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Thioesterase]]		[[Category: Thioesterase]]

OCA at 10:59, 3 October 2014

2014-10-03T10:59:02Z

←Older revision		Revision as of 10:59, 3 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1lo7.~~png~~\|~~left~~\|200px]]	+	==X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA==
		+	<StructureSection load='1lo7' size='340' side='right' caption='[[1lo7]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CO:4-HYDROXYPHENACYL+COENZYME+A'>4CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lo8\|1lo8]], [[1lo9\|1lo9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">4HBT_PSESP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72586 Pseudomonas sp. CBS3])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxybenzoyl-CoA_thioesterase 4-hydroxybenzoyl-CoA thioesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.23 3.1.2.23] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lo7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The metabolic pathway by which 4-chlorobenzoate is degraded to 4-hydroxybenzoate in the soil-dwelling microbe Pseudomonas sp. strain CBS-3 consists of three enzymes including 4-hydroxybenzoyl-CoA thioesterase. The structure of the unbound form of this thioesterase has been shown to contain the so-called "hot dog" fold with a large helix packed against a five-stranded anti-parallel beta-sheet. To address the manner in which the enzyme accommodates the substrate within the active site, two inhibitors have been synthesized, namely 4-hydroxyphenacyl-CoA and 4-hydroxybenzyl-CoA. Here we describe the structural analyses of the enzyme complexed with these two inhibitors determined and refined to 1.5 and 1.8 A resolution, respectively. These studies indicate that only one protein side chain, Ser(91), participates directly in ligand binding. All of the other interactions between the protein and the inhibitors are mediated through backbone peptidic NH groups, carbonyl oxygens, and/or solvents. The structures of the enzyme-inhibitor complexes suggest that both a hydrogen bond and the positive end of a helix dipole moment serve to polarize the electrons away from the carbonyl carbon of the acyl group, thereby making it more susceptible to nucleophilic attack. Additionally, these studies demonstrate that the carboxylate group of Asp(17) is approximately 3.2 A from the carbonyl carbon of the acyl group. To address the role of Asp(17), the structure of the site-directed mutant protein D17N with bound substrate has also been determined. Taken together, these investigations suggest that the reaction mechanism may proceed through an acyl enzyme intermediate.

-	~~{{STRUCTURE_1lo7\| PDB=1lo7 \| SCENE= }}~~	+	X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.,Thoden JB, Holden HM, Zhuang Z, Dunaway-Mariano D J Biol Chem. 2002 Jul 26;277(30):27468-76. Epub 2002 May 7. PMID:11997398<ref>PMID:11997398</ref>

-	~~===X-ray structure~~ of ~~4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_11997398}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1lo7]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_sp~~.~~_cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA].~~	+

	==See Also==		==See Also==
-	*[[Penicillin-binding protein\|Penicillin-binding protein]]
	*[[Thioesterase\|Thioesterase]]		*[[Thioesterase\|Thioesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:011997398<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]		[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
	[[Category: Pseudomonas sp. cbs3]]		[[Category: Pseudomonas sp. cbs3]]

OCA at 09:00, 20 October 2012

2012-10-20T09:00:40Z

←Older revision		Revision as of 09:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1lo7]] is a 1 chain structure ~~of [[Penicillin-binding protein]] and [[Thioesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA].	+	[[1lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA].

	==See Also==		==See Also==

OCA: Protected "1lo7" [edit=sysop:move=sysop]

2012-07-25T21:29:40Z

Protected "1lo7" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:29, 25 July 2012

OCA at 21:29, 25 July 2012

2012-07-25T21:29:38Z

←Older revision		Revision as of 21:29, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1lo7.png\|left\|200px]]		[[Image:1lo7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1lo7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1lo7\| PDB=1lo7 \| SCENE= }}		{{STRUCTURE_1lo7\| PDB=1lo7 \| SCENE= }}

	===X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA===		===X-ray structure of 4-Hydroxybenzoyl CoA Thioesterase complexed with 4-hydroxyphenacyl CoA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_11997398}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 11997398 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_11997398}}		{{ABSTRACT_PUBMED_11997398}}

	==About this Structure==		==About this Structure==
-	~~1LO7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA].	+	[[1lo7]] is a 1 chain structure of [[Penicillin-binding protein]] and [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp._cbs3 Pseudomonas sp. cbs3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO7 OCA].
		+
		+	==See Also==
		+	*[[Penicillin-binding protein\|Penicillin-binding protein]]
		+	*[[Thioesterase\|Thioesterase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~11997398~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:011997398</ref><references group="xtra"/>
	[[Category: 4-hydroxybenzoyl-CoA thioesterase]]		[[Category: 4-hydroxybenzoyl-CoA thioesterase]]
-	[[Category: Pseudomonas sp.]]	+	[[Category: Pseudomonas sp. cbs3]]
	[[Category: Dunaway-Mariano, D.]]		[[Category: Dunaway-Mariano, D.]]
	[[Category: Holden, H M.]]		[[Category: Holden, H M.]]
Line 32:		Line 24:
	[[Category: Catalytic mechanism]]		[[Category: Catalytic mechanism]]
	[[Category: Hot dog fold]]		[[Category: Hot dog fold]]
		+	[[Category: Hydrolase]]
	[[Category: Thioesterase]]		[[Category: Thioesterase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:00:39 2009''