1lou - Revision history

OCA at 09:16, 16 August 2023

2023-08-16T09:16:22Z

←Older revision		Revision as of 09:16, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='1lou' size='340' side='right'caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1lou' size='340' side='right'caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [https://pdbe.org/1lou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [https://www.ebi.ac.uk/pdbsum/1lou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lou ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [https://pdbe.org/1lou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [https://www.ebi.ac.uk/pdbsum/1lou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).	+	[https://www.uniprot.org/uniprot/RS6_THETH RS6_THETH] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kristensen, O~~]]	+	[[Category: Thermus thermophilus]]
-	[[Category: ~~Oliveberg, M~~]]	+	[[Category: Kristensen O]]
-	[[Category: ~~Otzen, D E]]~~	+	[[Category: Oliveberg M]]
-	~~[[Category: Proctor,~~ M]]	+	[[Category: Otzen DE]]
-	[[Category: ~~Protein engineering~~]]	+	[[Category: Proctor M]]
-	[[Category: ~~Protein folding]]~~	+
-	~~[[Category: Reaction coordinate]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Transition state]]~~	+
-	~~[[Category: Two-state model~~]]	+

OCA at 06:47, 18 August 2021

2021-08-18T06:47:23Z

←Older revision		Revision as of 06:47, 18 August 2021
Line 3:		Line 3:
	<StructureSection load='1lou' size='340' side='right'caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1lou' size='340' side='right'caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [~~http~~://pdbe.org/1lou PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lou PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lou ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [https://pdbe.org/1lou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [https://www.ebi.ac.uk/pdbsum/1lou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).	+	[[https://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:24, 13 November 2019

2019-11-13T12:24:54Z

←Older revision		Revision as of 12:24, 13 November 2019
Line 1:		Line 1:

	==RIBOSOMAL PROTEIN S6==		==RIBOSOMAL PROTEIN S6==
-	<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='1lou' size='340' side='right'caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1lou" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lou" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S6\|Ribosomal protein S6]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]		[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
		+	[[Category: Large Structures]]
	[[Category: Kristensen, O]]		[[Category: Kristensen, O]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]

OCA at 08:00, 31 January 2018

2018-01-31T08:00:22Z

←Older revision		Revision as of 08:00, 31 January 2018
Line 1:		Line 1:
		+
	==RIBOSOMAL PROTEIN S6==		==RIBOSOMAL PROTEIN S6==
	<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://pdbe.org/1lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://pdbe.org/1lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lou_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lou_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1lou" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lou" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ribosomal protein S6\|Ribosomal protein S6]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:48, 9 February 2016

2016-02-09T11:48:17Z

←Older revision		Revision as of 11:48, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lou ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:55, 10 September 2015

2015-09-10T21:55:52Z

←Older revision		Revision as of 21:55, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://pdbe.org/1lou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lou" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
	[[Category: Kristensen, O]]		[[Category: Kristensen, O]]
	[[Category: Oliveberg, M]]		[[Category: Oliveberg, M]]

OCA at 06:36, 25 December 2014

2014-12-25T06:36:35Z

←Older revision		Revision as of 06:36, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RS6_THETH RS6_THETH]] Located on the outer edge of the platform on the body of the 30S subunit (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Kristensen, O.]]	+	[[Category: Kristensen, O]]
-	[[Category: Oliveberg, M.]]	+	[[Category: Oliveberg, M]]
-	[[Category: Otzen, D E.]]	+	[[Category: Otzen, D E]]
-	[[Category: Proctor, M.]]	+	[[Category: Proctor, M]]
	[[Category: Protein engineering]]		[[Category: Protein engineering]]
	[[Category: Protein folding]]		[[Category: Protein folding]]

OCA at 18:15, 28 September 2014

2014-09-28T18:15:38Z

←Older revision		Revision as of 18:15, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1lou.~~png\|left~~\|200px]]	+	==RIBOSOMAL PROTEIN S6==
		+	<StructureSection load='1lou' size='340' side='right' caption='[[1lou]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LOU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lou OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lou RCSB], [http://www.ebi.ac.uk/pdbsum/1lou PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/1lou_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interpretation of folding rates is often rationalized within the context of transition state theory. This means that the reaction rate is linked to an activation barrier, the height of which is determined by the free energy difference between a ground state (the starting point) and an apparent transition state. Changes in the folding kinetics are thus caused by effects on either the ground state, the transition state, or both. However, structural changes of the transition state are rarely discussed in connection with experimental data, and kinetic anomalies are commonly ascribed to ground state effects alone, e.g., depletion or accumulation of structural intermediates upon addition of denaturant. In this study, we present kinetic data which are best described by transition state changes. We also show that ground state effects and transition state effects are in general difficult to distinguish kinetically. The analysis is based on the structurally homologous proteins U1A and S6. Both proteins display two-state behavior, but there is a marked difference in their kinetics. S6 exhibits a classical V-shaped chevron plot (log observed rate constant vs denaturant concentration), whereas U1A's chevron plot is symmetrically curved, like an inverted bell curve. However, S6 is readily mutated to display U1A-like kinetics. The seemingly drastic effects of these mutations are readily ascribed to transition state movements where large kinetic differences result from relatively small alterations of a common free energy profile and broad activation barriers.

-	~~{{STRUCTURE_1lou\| PDB=1lou \| SCENE= }}~~	+	Structural changes in the transition state of protein folding: alternative interpretations of curved chevron plots.,Otzen DE, Kristensen O, Proctor M, Oliveberg M Biochemistry. 1999 May 18;38(20):6499-511. PMID:10350468<ref>PMID:10350468</ref>

-	~~===RIBOSOMAL PROTEIN S6===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10350468}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1lou]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA].~~	+

	==See Also==		==See Also==
	*[[Ribosomal protein S6\|Ribosomal protein S6]]		*[[Ribosomal protein S6\|Ribosomal protein S6]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010350468<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Kristensen, O.]]		[[Category: Kristensen, O.]]

OCA at 13:44, 20 October 2012

2012-10-20T13:44:13Z

←Older revision		Revision as of 13:44, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1lou]] is a 1 chain structure ~~of [[Ribosomal protein S6]]~~ with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA].	+	[[1lou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOU OCA].

	==See Also==		==See Also==

OCA: Protected "1lou" [edit=sysop:move=sysop]

2012-07-26T12:56:29Z

Protected "1lou" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:56, 26 July 2012