1lr8 - Revision history

OCA at 14:51, 20 September 2023

2023-09-20T14:51:22Z

←Older revision		Revision as of 14:51, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [https://pdbe.org/1lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [https://pdbe.org/1lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:44, 21 December 2022

2022-12-21T09:44:28Z

←Older revision		Revision as of 09:44, 21 December 2022
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	<StructureSection load='1lr8' size='340' side='right'caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1lr8' size='340' side='right'caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lr7\|1lr7]], [[1lr9\|1lr9]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [https://pdbe.org/1lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [https://pdbe.org/1lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	+	[https://www.uniprot.org/uniprot/FST_RAT FST_RAT] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hyvonen, M~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Innis, C A~~]]	+	[[Category: Hyvonen M]]
-	[[Category: ~~Cystine-rich]]~~	+	[[Category: Innis CA]]
-	~~[[Category: D-myo-inositol hexasulphate]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 05:55, 28 April 2021

2021-04-28T05:55:46Z

←Older revision		Revision as of 05:55, 28 April 2021
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	<StructureSection load='1lr8' size='340' side='right'caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1lr8' size='340' side='right'caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lr7\|1lr7]], [[1lr9\|1lr9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [~~http~~://pdbe.org/1lr8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [https://pdbe.org/1lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	+	[[https://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1lr8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lr8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Follistatin\|Follistatin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:49, 24 July 2019

2019-07-24T06:49:54Z

←Older revision		Revision as of 06:49, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)==		==Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)==
-	<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='1lr8' size='340' side='right'caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Hyvonen, M]]		[[Category: Hyvonen, M]]
	[[Category: Innis, C A]]		[[Category: Innis, C A]]

OCA at 08:07, 31 January 2018

2018-01-31T08:07:09Z

←Older revision		Revision as of 08:07, 31 January 2018
Line 1:		Line 1:
		+
	==Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)==		==Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)==
	<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://pdbe.org/1lr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://pdbe.org/1lr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:51, 10 February 2016

2016-02-10T06:51:47Z

←Older revision		Revision as of 06:51, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lr8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:26, 11 September 2015

2015-09-11T06:26:14Z

←Older revision		Revision as of 06:26, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://pdbe.org/1lr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lr8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Hyvonen, M]]		[[Category: Hyvonen, M]]
	[[Category: Innis, C A]]		[[Category: Innis, C A]]

OCA at 12:33, 25 December 2014

2014-12-25T12:33:31Z

←Older revision		Revision as of 12:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Hyvonen, M.]]	+	[[Category: Hyvonen, M]]
-	[[Category: Innis, C A.]]	+	[[Category: Innis, C A]]
	[[Category: Cystine-rich]]		[[Category: Cystine-rich]]
	[[Category: D-myo-inositol hexasulphate]]		[[Category: D-myo-inositol hexasulphate]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]

OCA at 14:37, 28 September 2014

2014-09-28T14:37:57Z

←Older revision		Revision as of 14:37, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1lr8.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)==
		+	<StructureSection load='1lr8' size='340' side='right' caption='[[1lr8]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lr8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHS:D-MYO-INOSITOL-HEXASULPHATE'>IHS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr9\|1lr9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr8 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Follistatin associates with transforming growth factor-beta-like growth factors such as activin or bone morphogenetic proteins to form an inactive complex, thereby regulating processes as diverse as embryonic development and cell secretion. Although an interaction between heparan sulfate chains present at the cell surface and follistatin has been recorded, the impact of this binding reaction on the follistatin-mediated inhibition of transforming growth factor-beta-like signaling remains unclear. To gain a structural insight into this interaction, we have solved the crystal structure of the presumed heparan sulfate-binding domain of follistatin, both alone and in complex with the small heparin analogs sucrose octasulfate and D-myo-inositol hexasulfate. In addition, we have confirmed the binding of the sucrose octasulfate and D-myo-inositol hexasulfate molecules to this follistatin domain and determined the association constants and stoichiometries of both interactions in solution using isothermal titration calorimetry. Overall, our results shed light upon the structure of this follistatin domain and reveal a novel conformation for a hinge region connecting epidermal growth factor-like and Kazal-like subdomains compared with the follistatin-like domain found in the extracellular matrix protein BM-40. Moreover, the crystallographic analysis of the two protein-ligand complexes mentioned above leads us to propose a potential location for the heparan sulfate-binding site on the surface of follistatin and to suggest the involvement of residues Asn80 and Arg86 in such a follistatin-heparin interaction.

-	~~{{STRUCTURE_1lr8\| PDB=1lr8 \| SCENE= }}~~	+	Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding.,Innis CA, Hyvonen M J Biol Chem. 2003 Oct 10;278(41):39969-77. Epub 2003 Jul 16. PMID:12867435<ref>PMID:12867435</ref>

-	~~===Crystal structure of Fs1~~, ~~the heparin-binding domain~~ of ~~follistatin, complexed with~~ the ~~heparin analogue D-myo-inositol hexasulphate (Ins6S)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12867435}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lr8]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LR8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012867435<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Hyvonen, M.]]		[[Category: Hyvonen, M.]]

OCA: Protected "1lr8" [edit=sysop:move=sysop]

2012-12-05T20:16:08Z

Protected "1lr8" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:16, 5 December 2012