1lr9 - Revision history

OCA at 14:51, 20 September 2023

2023-09-20T14:51:25Z

←Older revision		Revision as of 14:51, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [https://pdbe.org/1lr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [https://pdbe.org/1lr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 09:44, 21 December 2022

2022-12-21T09:44:33Z

←Older revision		Revision as of 09:44, 21 December 2022
Line 3:		Line 3:
	<StructureSection load='1lr9' size='340' side='right'caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lr9' size='340' side='right'caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lr7\|1lr7]], [[1lr8\|1lr8]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [https://pdbe.org/1lr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [https://pdbe.org/1lr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	+	[https://www.uniprot.org/uniprot/FST_RAT FST_RAT] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hyvonen, M~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Innis, C A~~]]	+	[[Category: Hyvonen M]]
-	[[Category: ~~Cystine-rich]]~~	+	[[Category: Innis CA]]
-	~~[[Category: Follistatin]]~~	+
-	~~[[Category: Fs1]]~~	+
-	~~[[Category: Heparin-binding]]~~	+
-	~~[[Category: Hormone-growth factor complex~~]]	+

OCA at 05:55, 28 April 2021

2021-04-28T05:55:47Z

←Older revision		Revision as of 05:55, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1lr9' size='340' side='right'caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lr9' size='340' side='right'caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lr7\|1lr7]], [[1lr8\|1lr8]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [~~http~~://pdbe.org/1lr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [https://pdbe.org/1lr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	+	[[https://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1lr9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1lr9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Follistatin\|Follistatin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:49, 24 July 2019

2019-07-24T06:49:58Z

←Older revision		Revision as of 06:49, 24 July 2019
Line 1:		Line 1:

	==STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN==		==STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN==
-	<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1lr9' size='340' side='right'caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Hyvonen, M]]		[[Category: Hyvonen, M]]
	[[Category: Innis, C A]]		[[Category: Innis, C A]]

OCA at 08:12, 31 January 2018

2018-01-31T08:12:32Z

←Older revision		Revision as of 08:12, 31 January 2018
Line 1:		Line 1:
		+
	==STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN==		==STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN==
	<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://pdbe.org/1lr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://pdbe.org/1lr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:59, 9 February 2016

2016-02-09T22:59:56Z

←Older revision		Revision as of 22:59, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lr9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:54, 11 September 2015

2015-09-11T02:54:29Z

←Older revision		Revision as of 02:54, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://pdbe.org/1lr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1lr9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Hyvonen, M]]		[[Category: Hyvonen, M]]
	[[Category: Innis, C A]]		[[Category: Innis, C A]]

OCA at 10:07, 25 December 2014

2014-12-25T10:07:03Z

←Older revision		Revision as of 10:07, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FST_RAT FST_RAT]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Hyvonen, M.]]	+	[[Category: Hyvonen, M]]
-	[[Category: Innis, C A.]]	+	[[Category: Innis, C A]]
	[[Category: Cystine-rich]]		[[Category: Cystine-rich]]
	[[Category: Follistatin]]		[[Category: Follistatin]]

OCA at 16:18, 28 September 2014

2014-09-28T16:18:44Z

←Older revision		Revision as of 16:18, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1lr9.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN==
		+	<StructureSection load='1lr9' size='340' side='right' caption='[[1lr9]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1lr9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LR9 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lr7\|1lr7]], [[1lr8\|1lr8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/1lr9 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Follistatin associates with transforming growth factor-beta-like growth factors such as activin or bone morphogenetic proteins to form an inactive complex, thereby regulating processes as diverse as embryonic development and cell secretion. Although an interaction between heparan sulfate chains present at the cell surface and follistatin has been recorded, the impact of this binding reaction on the follistatin-mediated inhibition of transforming growth factor-beta-like signaling remains unclear. To gain a structural insight into this interaction, we have solved the crystal structure of the presumed heparan sulfate-binding domain of follistatin, both alone and in complex with the small heparin analogs sucrose octasulfate and D-myo-inositol hexasulfate. In addition, we have confirmed the binding of the sucrose octasulfate and D-myo-inositol hexasulfate molecules to this follistatin domain and determined the association constants and stoichiometries of both interactions in solution using isothermal titration calorimetry. Overall, our results shed light upon the structure of this follistatin domain and reveal a novel conformation for a hinge region connecting epidermal growth factor-like and Kazal-like subdomains compared with the follistatin-like domain found in the extracellular matrix protein BM-40. Moreover, the crystallographic analysis of the two protein-ligand complexes mentioned above leads us to propose a potential location for the heparan sulfate-binding site on the surface of follistatin and to suggest the involvement of residues Asn80 and Arg86 in such a follistatin-heparin interaction.

-	~~{{STRUCTURE_1lr9\| PDB=1lr9 \| SCENE= }}~~	+	Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding.,Innis CA, Hyvonen M J Biol Chem. 2003 Oct 10;278(41):39969-77. Epub 2003 Jul 16. PMID:12867435<ref>PMID:12867435</ref>

-	~~===STRUCTURE OF Fs1~~, ~~THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12867435}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1lr9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1LR9 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012867435<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Hyvonen, M.]]		[[Category: Hyvonen, M.]]

OCA: Protected "1lr9" [edit=sysop:move=sysop]

2012-12-05T21:25:33Z

Protected "1lr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:25, 5 December 2012