1ltp - Revision history

OCA at 06:49, 18 August 2021

2021-08-18T06:49:08Z

←Older revision		Revision as of 06:49, 18 August 2021
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	<StructureSection load='1ltp' size='340' side='right'caption='[[1ltp]]' scene=''>		<StructureSection load='1ltp' size='340' side='right'caption='[[1ltp]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1LTP FirstGlance]. <br>	+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LTP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ltp FirstGlance], [~~http~~://www.ebi.ac.uk/pdbsum/1ltp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltp ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ltp FirstGlance], [https://www.ebi.ac.uk/pdbsum/1ltp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:13, 13 November 2019

2019-11-13T12:13:04Z

←Older revision		Revision as of 12:13, 13 November 2019
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	==MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA==		==MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA==
-	<StructureSection load='1ltp' size='340' side='right' caption='[[1ltp]]' scene=''>	+	<StructureSection load='1ltp' size='340' side='right'caption='[[1ltp]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Theoretical Model]]		[[Category: Theoretical Model]]
		+	[[Category: Large Structures]]
	[[Category: Matthews, K S]]		[[Category: Matthews, K S]]
	[[Category: Nichols, J C]]		[[Category: Nichols, J C]]
	[[Category: Quiocho, F A]]		[[Category: Quiocho, F A]]
	[[Category: Vyas, N K]]		[[Category: Vyas, N K]]

OCA at 07:49, 31 January 2018

2018-01-31T07:49:09Z

←Older revision		Revision as of 07:49, 31 January 2018
Line 5:		Line 5:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ltp PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ltp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:21, 11 February 2016

2016-02-11T09:21:02Z

←Older revision		Revision as of 09:21, 11 February 2016
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		+	{{Theoretical_model}}
		+
	==MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA==		==MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA==
	<StructureSection load='1ltp' size='340' side='right' caption='[[1ltp]]' scene=''>		<StructureSection load='1ltp' size='340' side='right' caption='[[1ltp]]' scene=''>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Theoretical Model]]
	[[Category: Matthews, K S]]		[[Category: Matthews, K S]]
	[[Category: Nichols, J C]]		[[Category: Nichols, J C]]
	[[Category: Quiocho, F A]]		[[Category: Quiocho, F A]]
	[[Category: Vyas, N K]]		[[Category: Vyas, N K]]

OCA at 12:33, 10 September 2015

2015-09-10T12:33:16Z

←Older revision		Revision as of 12:33, 10 September 2015
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ltp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:33, 5 January 2015

2015-01-05T16:33:48Z

←Older revision		Revision as of 16:33, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>		<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ltp PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ltp PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:57, 28 September 2014

2014-09-28T14:57:50Z

←Older revision		Revision as of 14:57, 28 September 2014
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-	~~{{Theoretical_model}}~~	+	==MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA==
		+	<StructureSection load='1ltp' size='340' side='right' caption='[[1ltp]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTP FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltp FirstGlance], [http://www.ebi.ac.uk/pdbsum/1ltp PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Using primary sequence similarity to arabinose-binding protein, D-glucose/D-galactose-binding protein, and ribose-binding protein (Vyas, N. K., Vyas, M. N., and Quiocho, F. A. (1991) J. Biol. Chem. 266, 5226-5237; Mowbray, S. L., and Cole, L. B. (1992) J. Mol. Biol. 225, 155-175), the core domain (residues 62-323) of the bacterial regulatory protein lac repressor has been aligned to these sugar-binding proteins of known structure. Although the sequence identity is not striking, there is strong overall homology based on two separate matrix scoring systems (minimum base change per codon (MBC/C) and amino acid homology per residue (AAH/R)) (mean score: MBC/C < 1.25, AAH/R > 5.50; random sequences: MBC/C = 1.45, AAH/R = 4.46). Similarly, the predicted secondary structure of the repressor exhibits excellent agreement with the known secondary structures of the sugar-binding proteins. Using this primary sequence alignment, the tertiary structure of the core domain of the lac repressor has been modeled based on the known structures of the sugar-binding proteins as templates. While the structure deduced for the repressor is hypothetical, the model generated allows a comparison between the predicted tertiary arrangement and the wealth of genetic and chemical data elucidated for the repressor. Important residues involved in operator and sugar binding and in protein assembly have been identified using genetic methods, and placement of these residues in the model is consistent with their known function. This approach, therefore, provides a means to visualize the core domain of the lac repressor that allows interpretation of genetic and chemical data for specific residues and rational design of future experiments.

-	~~[[Image~~:~~1ltp~~.~~png\|left\|200px]]~~	+	Model of lactose repressor core based on alignment with sugar-binding proteins is concordant with genetic and chemical data.,Nichols JC, Vyas NK, Quiocho FA, Matthews KS J Biol Chem. 1993 Aug 15;268(23):17602-12. PMID:8349639<ref>PMID:8349639</ref>

-	~~{{STRUCTURE_1ltp\| PDB=1ltp \| SCENE= }}~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	==~~=MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA===~~	+	== References ==
-		+	<references/>
-	~~{{ABSTRACT_PUBMED_8349639}}~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:008349639<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Matthews, K S]]		[[Category: Matthews, K S]]
	[[Category: Nichols, J C]]		[[Category: Nichols, J C]]
	[[Category: Quiocho, F A]]		[[Category: Quiocho, F A]]
	[[Category: Vyas, N K]]		[[Category: Vyas, N K]]

OCA: Protected "1ltp" [edit=sysop:move=sysop]

2012-10-21T09:36:24Z

Protected "1ltp" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 21 October 2012

OCA at 09:36, 21 October 2012

2012-10-21T09:36:21Z

←Older revision		Revision as of 09:36, 21 October 2012
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	{{Theoretical_model}}		{{Theoretical_model}}
-	~~{{Seed}}~~	+
	[[Image:1ltp.png\|left\|200px]]		[[Image:1ltp.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ltp", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1ltp\| PDB=1ltp \| SCENE= }}		{{STRUCTURE_1ltp\| PDB=1ltp \| SCENE= }}

	===MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA===		===MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8349639}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8349639 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8349639}}		{{ABSTRACT_PUBMED_8349639}}
-
-	==About this Structure==
-	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTP OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8349639~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008349639</ref><references group="xtra"/>
	[[Category: Matthews, K S]]		[[Category: Matthews, K S]]
	[[Category: Nichols, J C]]		[[Category: Nichols, J C]]
	[[Category: Quiocho, F A]]		[[Category: Quiocho, F A]]
	[[Category: Vyas, N K]]		[[Category: Vyas, N K]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:38:19 2010''

OCA at 05:38, 8 April 2010

2010-04-08T05:38:20Z

←Older revision		Revision as of 05:38, 8 April 2010
Line 1:		Line 1:
-	~~'''Theoretical Model'''~~	+	{{Theoretical_model}}
		+	{{Seed}}
		+	[[Image:1ltp.png\|left\|200px]]

-	The ~~entry 1LTP~~ is ~~a Theoretical Model titled 'MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA'~~.	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_1ltp", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_1ltp\| PDB=1ltp \| SCENE= }}

-	~~[[Category:Theoretical Model]]~~	+	===MODEL OF LACTOSE REPRESSOR CORE BASED ON ALIGNMENT WITH SUGAR BINDING PROTEINS IS CONCORDANT WITH GENETIC AND CHEMICAL DATA===


-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 30 09~~:51:~~21 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_8349639}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8349639 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8349639}}
		+
		+	==About this Structure==
		+	Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTP OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:8349639</ref><references group="xtra"/>
		+	[[Category: Matthews, K S]]
		+	[[Category: Nichols, J C]]
		+	[[Category: Quiocho, F A]]
		+	[[Category: Vyas, N K]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 8 08:38:19 2010''