1mfg - Revision history

OCA at 07:43, 14 February 2024

2024-02-14T07:43:34Z

←Older revision		Revision as of 07:43, 14 February 2024
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	<StructureSection load='1mfg' size='340' side='right'caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='1mfg' size='340' side='right'caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1MFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~1mfl~~\|~~1mfl~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [~~http~~://pdbe.org/1mfg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [https://pdbe.org/1mfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [https://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~LAP2_HUMAN LAP2_HUMAN]~~] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.<ref>PMID:10878805</ref>	+	[https://www.uniprot.org/uniprot/ERBIN_HUMAN ERBIN_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).<ref>PMID:10878805</ref> <ref>PMID:16203728</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mfg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mfg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Erbin contains a class I PDZ domain that binds to the C-terminal region of the receptor tyrosine kinase ErbB2, a class II ligand. The crystal structure of the human Erbin PDZ bound to the peptide EYLGLDVPV corresponding to the C-terminal residues 1247-1255 of human ErbB2 has been determined at 1.25-A resolution. The Erbin PDZ deviates from the canonical PDZ fold in that it contains a single alpha-helix. The isopropyl group of valine at position -2 of the ErbB2 peptide interacts with the Erbin Val(1351) and displaces the peptide backbone away from the alpha-helix, elucidating the molecular basis of class II ligand recognition by a class I PDZ domain. Strikingly, the phenolic ring of tyrosine -7 enters into a pocket formed by the extended beta 2-beta 3 loop of the Erbin PDZ. Phosphorylation of tyrosine -7 abolishes this interaction but does not affect the binding of the four C-terminal peptidic residues to PDZ, as revealed by the crystal structure of the Erbin PDZ complexed with a phosphotyrosine-containing ErbB2 peptide. Since phosphorylation of tyrosine -7 plays a critical role in ErbB2 function, the selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB2-mediated signaling and oncogenicity.
-
-	Novel mode of ligand recognition by the Erbin PDZ domain.,Birrane G, Chung J, Ladias JA J Biol Chem. 2003 Jan 17;278(3):1399-402. Epub 2002 Nov 19. PMID:12444095<ref>PMID:12444095</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mfg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Birrane, G]]	+	[[Category: Birrane G]]
-	[[Category: Chung, J]]	+	[[Category: Chung J]]
-	[[Category: Ladias~~, J A]]~~	+	[[Category: Ladias JA]]
-	~~[[Category: Erb-b2]]~~	+
-	~~[[Category: Erbin]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 06:33, 14 October 2020

2020-10-14T06:33:02Z

←Older revision		Revision as of 06:33, 14 October 2020
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	==The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor==		==The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor==
-	<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>	+	<StructureSection load='1mfg' size='340' side='right'caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Birrane, G]]		[[Category: Birrane, G]]
	[[Category: Chung, J]]		[[Category: Chung, J]]

OCA at 07:07, 9 January 2019

2019-01-09T07:07:13Z

←Older revision		Revision as of 07:07, 9 January 2019
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	<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mfg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mfg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Birrane, G]]		[[Category: Birrane, G]]
	[[Category: Chung, J]]		[[Category: Chung, J]]

OCA at 06:48, 5 April 2017

2017-04-05T06:48:23Z

←Older revision		Revision as of 06:48, 5 April 2017
Line 1:		Line 1:
		+
	==The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor==		==The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor==
	<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Birrane, G]]		[[Category: Birrane, G]]
	[[Category: Chung, J]]		[[Category: Chung, J]]

OCA at 07:37, 10 February 2016

2016-02-10T07:37:41Z

←Older revision		Revision as of 07:37, 10 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mfg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:45, 11 September 2015

2015-09-11T06:45:56Z

←Older revision		Revision as of 06:45, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://pdbe.org/1mfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mfg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Birrane, G]]		[[Category: Birrane, G]]
	[[Category: Chung, J]]		[[Category: Chung, J]]

OCA at 12:46, 25 December 2014

2014-12-25T12:46:21Z

←Older revision		Revision as of 12:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LAP2_HUMAN LAP2_HUMAN]] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.<ref>PMID:10878805</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Birrane, G.]]	+	[[Category: Birrane, G]]
-	[[Category: Chung, J.]]	+	[[Category: Chung, J]]
-	[[Category: Ladias, J A.]]	+	[[Category: Ladias, J A]]
	[[Category: Erb-b2]]		[[Category: Erb-b2]]
-	[[Category: Erbin.]]	+	[[Category: Erbin]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 15:26, 29 September 2014

2014-09-29T15:26:25Z

←Older revision		Revision as of 15:26, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1mfg\| PDB=1mfg \| SCENE= }}~~	+	==The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor==
-	===The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor===	+	<StructureSection load='1mfg' size='340' side='right' caption='[[1mfg]], [[Resolution\|resolution]] 1.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_12444095}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mfg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFG FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mfl\|1mfl]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mfg RCSB], [http://www.ebi.ac.uk/pdbsum/1mfg PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mf/1mfg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Erbin contains a class I PDZ domain that binds to the C-terminal region of the receptor tyrosine kinase ErbB2, a class II ligand. The crystal structure of the human Erbin PDZ bound to the peptide EYLGLDVPV corresponding to the C-terminal residues 1247-1255 of human ErbB2 has been determined at 1.25-A resolution. The Erbin PDZ deviates from the canonical PDZ fold in that it contains a single alpha-helix. The isopropyl group of valine at position -2 of the ErbB2 peptide interacts with the Erbin Val(1351) and displaces the peptide backbone away from the alpha-helix, elucidating the molecular basis of class II ligand recognition by a class I PDZ domain. Strikingly, the phenolic ring of tyrosine -7 enters into a pocket formed by the extended beta 2-beta 3 loop of the Erbin PDZ. Phosphorylation of tyrosine -7 abolishes this interaction but does not affect the binding of the four C-terminal peptidic residues to PDZ, as revealed by the crystal structure of the Erbin PDZ complexed with a phosphotyrosine-containing ErbB2 peptide. Since phosphorylation of tyrosine -7 plays a critical role in ErbB2 function, the selective binding and sequestration of this residue in its unphosphorylated state by the Erbin PDZ provides a novel mechanism for regulation of the ErbB2-mediated signaling and oncogenicity.

-	~~==Function==~~	+	Novel mode of ligand recognition by the Erbin PDZ domain.,Birrane G, Chung J, Ladias JA J Biol Chem. 2003 Jan 17;278(3):1399-402. Epub 2002 Nov 19. PMID:12444095<ref>PMID:12444095</ref>
-	~~[[http://www.uniprot.org/uniprot/LAP2_HUMAN LAP2_HUMAN]] Acts as an adapter for~~ the ~~receptor ERBB2~~, ~~in epithelia~~. ~~By binding the unphosphorylated 'Tyr~~-~~1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state~~.<ref>PMID:~~10878805~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1mfg]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MFG OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:012444095</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Birrane, G.]]		[[Category: Birrane, G.]]

OCA at 02:13, 25 March 2013

2013-03-25T02:13:55Z

←Older revision		Revision as of 02:13, 25 March 2013
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-	[[Image:1mfg.png\|left\|200px]]
-
	{{STRUCTURE_1mfg\| PDB=1mfg \| SCENE= }}		{{STRUCTURE_1mfg\| PDB=1mfg \| SCENE= }}
-
	===The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor===		===The Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor===
		+	{{ABSTRACT_PUBMED_12444095}}

-	~~{{ABSTRACT_PUBMED_12444095}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LAP2_HUMAN LAP2_HUMAN]] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.<ref>PMID:10878805</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012444095</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012444095</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Birrane, G.]]		[[Category: Birrane, G.]]

OCA: Protected "1mfg" [edit=sysop:move=sysop]

2012-12-05T20:44:12Z

Protected "1mfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:44, 5 December 2012