1mft - Revision history

OCA at 07:43, 14 February 2024

2024-02-14T07:43:41Z

←Older revision		Revision as of 07:43, 14 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [https://pdbe.org/1mft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [https://www.ebi.ac.uk/pdbsum/1mft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [https://pdbe.org/1mft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [https://www.ebi.ac.uk/pdbsum/1mft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Although the analysis and design of turns that connect the strands in antiparallel beta-hairpins has reached an advanced state, much less is known concerning turns between antiparallel helices in helical hairpins. We have conducted an analysis of the structures and sequence preferences of two types of interhelical turns, each of which connects the two helices by a two-residue linker in an alphaL-beta conformation. Based on this analysis, it became apparent that the turn introduced into a designed four-helix bundle protein, DF1, did not occur within an optimal structural context. DF1 is a dimeric model for the diiron class of proteins. A longer loop with a beta-alphaR-beta conformation was inserted between two helices in the protein, and a sequence was chosen to stabilize its conformation. X-ray crystallography and NMR analysis of the protein showed the structure to be in excellent agreement with design.
-
-	Analysis and design of turns in alpha-helical hairpins.,Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF J Mol Biol. 2005 Mar 11;346(5):1441-54. Epub 2005 Jan 13. PMID:15713492<ref>PMID:15713492</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mft" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:08, 25 January 2023

2023-01-25T07:08:45Z

←Older revision		Revision as of 07:08, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='1mft' size='340' side='right'caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mft' size='340' side='right'caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [https://pdbe.org/1mft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [https://www.ebi.ac.uk/pdbsum/1mft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [https://pdbe.org/1mft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [https://www.ebi.ac.uk/pdbsum/1mft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: DeGrado, W]]	+	[[Category: DeGrado W]]
-	[[Category: Geremia, S]]	+	[[Category: Geremia S]]
-	[[Category: Kaplan, J]]	+	[[Category: Kaplan J]]
-	[[Category: Lahr~~, S J~~]]	+	[[Category: Lahr SJ]]
-	[[Category: North, B]]	+	[[Category: North B]]
-	[[Category: Stayrook~~, S E]]~~	+	[[Category: Stayrook SE]]
-	~~[[Category: Alpha-helical bundle]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Helix turn helix]]~~	+
-	~~[[Category: Protein design~~]]	+

OCA at 08:54, 21 April 2021

2021-04-21T08:54:20Z

←Older revision		Revision as of 08:54, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='1mft' size='340' side='right'caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mft' size='340' side='right'caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [~~http~~://pdbe.org/1mft PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mft PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [https://pdbe.org/1mft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [https://www.ebi.ac.uk/pdbsum/1mft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:06, 17 July 2019

2019-07-17T13:06:42Z

←Older revision		Revision as of 13:06, 17 July 2019
Line 1:		Line 1:

	==Crystal Structure Of Four-Helix Bundle Model==		==Crystal Structure Of Four-Helix Bundle Model==
-	<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1mft' size='340' side='right'caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: DeGrado, W]]		[[Category: DeGrado, W]]
	[[Category: Geremia, S]]		[[Category: Geremia, S]]

OCA at 12:47, 12 October 2017

2017-10-12T12:47:37Z

←Older revision		Revision as of 12:47, 12 October 2017
Line 3:		Line 3:
	<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: DeGrado, W]]		[[Category: DeGrado, W]]
	[[Category: Geremia, S]]		[[Category: Geremia, S]]

OCA at 06:50, 5 April 2017

2017-04-05T06:50:26Z

←Older revision		Revision as of 06:50, 5 April 2017
Line 1:		Line 1:
		+
	==Crystal Structure Of Four-Helix Bundle Model==		==Crystal Structure Of Four-Helix Bundle Model==
	<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://pdbe.org/1mft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://pdbe.org/1mft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mft ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus coli migula 1895]]
	[[Category: DeGrado, W]]		[[Category: DeGrado, W]]
	[[Category: Geremia, S]]		[[Category: Geremia, S]]

OCA at 22:43, 9 September 2015

2015-09-09T22:43:17Z

←Older revision		Revision as of 22:43, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://pdbe.org/1mft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mft" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: DeGrado, W]]		[[Category: DeGrado, W]]
	[[Category: Geremia, S]]		[[Category: Geremia, S]]

OCA at 15:30, 5 January 2015

2015-01-05T15:30:02Z

←Older revision		Revision as of 15:30, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: DeGrado, W.]]	+	[[Category: DeGrado, W]]
-	[[Category: Geremia, S.]]	+	[[Category: Geremia, S]]
-	[[Category: Kaplan, J.]]	+	[[Category: Kaplan, J]]
-	[[Category: Lahr, S J.]]	+	[[Category: Lahr, S J]]
-	[[Category: North, B.]]	+	[[Category: North, B]]
-	[[Category: Stayrook, S E.]]	+	[[Category: Stayrook, S E]]
	[[Category: Alpha-helical bundle]]		[[Category: Alpha-helical bundle]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Helix turn helix]]		[[Category: Helix turn helix]]
	[[Category: Protein design]]		[[Category: Protein design]]

OCA at 14:19, 28 September 2014

2014-09-28T14:19:58Z

←Older revision		Revision as of 14:19, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1mft.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure Of Four-Helix Bundle Model==
		+	<StructureSection load='1mft' size='340' side='right' caption='[[1mft]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mft]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MFT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jmb\|1jmb]], [[1jmo\|1jmo]], [[1ec5\|1ec5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mft RCSB], [http://www.ebi.ac.uk/pdbsum/1mft PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although the analysis and design of turns that connect the strands in antiparallel beta-hairpins has reached an advanced state, much less is known concerning turns between antiparallel helices in helical hairpins. We have conducted an analysis of the structures and sequence preferences of two types of interhelical turns, each of which connects the two helices by a two-residue linker in an alphaL-beta conformation. Based on this analysis, it became apparent that the turn introduced into a designed four-helix bundle protein, DF1, did not occur within an optimal structural context. DF1 is a dimeric model for the diiron class of proteins. A longer loop with a beta-alphaR-beta conformation was inserted between two helices in the protein, and a sequence was chosen to stabilize its conformation. X-ray crystallography and NMR analysis of the protein showed the structure to be in excellent agreement with design.

-	~~{{STRUCTURE_1mft\| PDB=1mft \| SCENE= }}~~	+	Analysis and design of turns in alpha-helical hairpins.,Lahr SJ, Engel DE, Stayrook SE, Maglio O, North B, Geremia S, Lombardi A, DeGrado WF J Mol Biol. 2005 Mar 11;346(5):1441-54. Epub 2005 Jan 13. PMID:15713492<ref>PMID:15713492</ref>

-	~~===Crystal Structure Of Four-Helix Bundle Model===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15713492}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1mft]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MFT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015713492<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: DeGrado, W.]]		[[Category: DeGrado, W.]]

OCA: Protected "1mft" [edit=sysop:move=sysop]

2012-12-05T19:45:54Z

Protected "1mft" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:45, 5 December 2012