1mo5 - Revision history

OCA at 07:18, 25 October 2023

2023-10-25T07:18:59Z

←Older revision		Revision as of 07:18, 25 October 2023
Line 3:		Line 3:
	<StructureSection load='1mo5' size='340' side='right'caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='1mo5' size='340' side='right'caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID~~-~~ADENYLATE+ESTER'>AGS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [https://pdbe.org/1mo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mo5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [https://pdbe.org/1mo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mo5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]	+	[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[~~Recombinase~~ A\|~~Recombinase~~ A]]	+	*[[3D structures of recombinase A\|3D structures of recombinase A]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Deleted entry]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chandra, N R~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Datta, S~~]]	+	[[Category: Chandra NR]]
-	[[Category: ~~Ganesh, N~~]]	+	[[Category: Datta S]]
-	[[Category: ~~Structural genomic]]~~	+	[[Category: Ganesh N]]
-	~~[[Category: Dna-repair]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Recombination]]~~	+
-	~~[[Category: Tbsgc~~]]	+

OCA at 09:53, 26 May 2021

2021-05-26T09:53:07Z

←Older revision		Revision as of 09:53, 26 May 2021
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	<StructureSection load='1mo5' size='340' side='right'caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='1mo5' size='340' side='right'caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [~~http~~://pdbe.org/1mo5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mo5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mo5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [https://pdbe.org/1mo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1mo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mo5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]	+	[[https://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:20, 21 August 2019

2019-08-21T07:20:17Z

←Older revision		Revision as of 07:20, 21 August 2019
Line 1:		Line 1:

	==RECA-ATP-GAMMA-S-MG COMPLEX==		==RECA-ATP-GAMMA-S-MG COMPLEX==
-	<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='1mo5' size='340' side='right'caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1mo5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1mo5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1mo5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mo5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Recombinase A\|Recombinase A]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
		+	[[Category: Large Structures]]
	[[Category: Chandra, N R]]		[[Category: Chandra, N R]]
	[[Category: Datta, S]]		[[Category: Datta, S]]

OCA at 00:26, 16 November 2017

2017-11-16T00:26:25Z

←Older revision		Revision as of 00:26, 16 November 2017
Line 1:		Line 1:
		+
	==RECA-ATP-GAMMA-S-MG COMPLEX==		==RECA-ATP-GAMMA-S-MG COMPLEX==
	<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://pdbe.org/1mo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://pdbe.org/1mo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mo5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1mo5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mo5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Recombinase A\|Recombinase A]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:42, 9 February 2016

2016-02-09T18:42:32Z

←Older revision		Revision as of 18:42, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mo5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:00, 11 September 2015

2015-09-11T01:00:06Z

←Older revision		Revision as of 01:00, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://pdbe.org/1mo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mo5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Chandra, N R]]		[[Category: Chandra, N R]]
	[[Category: Datta, S]]		[[Category: Datta, S]]

OCA at 08:45, 25 December 2014

2014-12-25T08:45:46Z

←Older revision		Revision as of 08:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RECA_MYCTU RECA_MYCTU]] Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.[HAMAP-Rule:MF_00268] PI-MtuI is an endonuclease.[HAMAP-Rule:MF_00268]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Chandra, N R.]]	+	[[Category: Chandra, N R]]
-	[[Category: Datta, S.]]	+	[[Category: Datta, S]]
-	[[Category: Ganesh, N.]]	+	[[Category: Ganesh, N]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Dna-repair]]		[[Category: Dna-repair]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category: Psi~~]]	+
	[[Category: Recombination]]		[[Category: Recombination]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]

OCA at 14:59, 28 September 2014

2014-09-28T14:59:40Z

←Older revision		Revision as of 14:59, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1mo5.~~png~~\|~~left~~\|200px]]	+	==RECA-ATP-GAMMA-S-MG COMPLEX==
		+	<StructureSection load='1mo5' size='340' side='right' caption='[[1mo5]], [[Resolution\|resolution]] 3.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MO5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mo3\|1mo3]], [[1mo4\|1mo4]], [[1mo6\|1mo6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.99.37 3.4.99.37] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mo5 RCSB], [http://www.ebi.ac.uk/pdbsum/1mo5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1mo5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RecA protein plays a crucial role in homologous recombination and repair of DNA. Central to all activities of RecA is its binding to Mg(+2)-ATP. The active form of the protein is a helical nucleoprotein filament containing the nucleotide cofactor and single-stranded DNA. The stability and structure of the helical nucleoprotein filament formed by RecA are modulated by nucleotide cofactors. Here we report crystal structures of a MtRecA-ADP complex, complexes with ATPgammaS in the presence and absence of magnesium as well as a complex with dATP and Mg+2. Comparison with the recently solved crystal structures of the apo form as well as a complex with ADP-AlF4 confirms an expansion of the P-loop region in MtRecA, compared to its homologue in Escherichia coli, correlating with the reduced affinity of MtRecA for ATP. The ligand bound structures reveal subtle variations in nucleotide conformations among different nucleotides that serve in maintaining the network of interactions crucial for nucleotide binding. The nucleotide binding site itself, however, remains relatively unchanged. The analysis also reveals that ATPgammaS rather than ADP-AlF4 is structurally a better mimic of ATP. From among the complexed structures, a definition for the two DNA-binding loops L1 and L2 has clearly emerged for the first time and provides a basis to understand DNA binding by RecA. The structural information obtained from these complexes correlates well with the extensive biochemical data on mutants available in the literature, contributing to an understanding of the role of individual residues in the nucleotide binding pocket, at the molecular level. Modeling studies on the mutants again point to the relative rigidity of the nucleotide binding site. Comparison with other NTP binding proteins reveals many commonalties in modes of binding by diverse members in the structural family, contributing to our understanding of the structural signature of NTP recognition.

-	~~{{STRUCTURE_1mo5\| PDB=1mo5 \| SCENE= }}~~	+	Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition.,Datta S, Ganesh N, Chandra NR, Muniyappa K, Vijayan M Proteins. 2003 Feb 15;50(3):474-85. PMID:12557189<ref>PMID:12557189</ref>

-	~~===RECA-ATP-GAMMA-S-MG COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12557189}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1mo5]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA].~~	+

	==See Also==		==See Also==
	*[[Recombinase A\|Recombinase A]]		*[[Recombinase A\|Recombinase A]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012557189<~~/~~ref~~><~~ref group="xtra">PMID:011121488</ref><ref group="xtra">PMID:008639660</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 14:46, 20 October 2012

2012-10-20T14:46:27Z

←Older revision		Revision as of 14:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1mo5]] is a 1 chain structure ~~of [[Recombinase A]]~~ with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA].	+	[[1mo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MO5 OCA].

	==See Also==		==See Also==
Line 14:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:012557189</ref><ref group="xtra">PMID:011121488</ref><ref group="xtra">PMID:008639660~~</ref><ref group="xtra">PMID:012391232~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012557189</ref><ref group="xtra">PMID:011121488</ref><ref group="xtra">PMID:008639660</ref><references group="xtra"/>
	[[Category: Deleted entry]]		[[Category: Deleted entry]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 16:12, 26 July 2012

2012-07-26T16:12:21Z

←Older revision		Revision as of 16:12, 26 July 2012
Line 1:		Line 1:
	[[Image:1mo5.png\|left\|200px]]		[[Image:1mo5.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1mo5\| PDB=1mo5 \| SCENE= }}		{{STRUCTURE_1mo5\| PDB=1mo5 \| SCENE= }}

	===RECA-ATP-GAMMA-S-MG COMPLEX===		===RECA-ATP-GAMMA-S-MG COMPLEX===

-
-	<!--
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	{{ABSTRACT_PUBMED_12557189}}		{{ABSTRACT_PUBMED_12557189}}

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	==See Also==		==See Also==
-	*[[Recombinase A]]	+	*[[Recombinase A\|Recombinase A]]

	==Reference==		==Reference==