1mqa - Revision history

OCA at 08:39, 10 April 2024

2024-04-10T08:39:35Z

←Older revision		Revision as of 08:39, 10 April 2024
Line 3:		Line 3:
	<StructureSection load='1mqa' size='340' side='right'caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mqa' size='340' side='right'caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1mq8\|1mq8]], [[1mq9\|1mq9]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [https://pdbe.org/1mqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [https://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [https://pdbe.org/1mqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [https://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.	+	[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqa ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.
-
-	Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.,Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA Cell. 2003 Jan 10;112(1):99-111. PMID:12526797<ref>PMID:12526797</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Integrin 3D structures\|Integrin 3D structures]]		*[[Integrin 3D structures\|Integrin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dong, Y]]	+	[[Category: Dong Y]]
-	[[Category: Jun, C D]]	+	[[Category: Jun C-D]]
-	[[Category: Liu, J H]]	+	[[Category: Liu J-H]]
-	[[Category: Shimaoka, T]]	+	[[Category: Shimaoka T]]
-	[[Category: Springer~~, T A~~]]	+	[[Category: Springer TA]]
-	[[Category: Takagi, J]]	+	[[Category: Takagi J]]
-	[[Category: Wang, J H]]	+	[[Category: Wang J-H]]
-	[[Category: Xiao, T]]	+	[[Category: Xiao T]]
-	[[Category: Yang, Y]]	+	[[Category: Yang Y]]
-	[[Category: Zhang, R]]	+	[[Category: Zhang R]]
-	~~[[Category: Designed disulfide bridge]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 14:56, 27 October 2021

2021-10-27T14:56:38Z

←Older revision		Revision as of 14:56, 27 October 2021
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	<StructureSection load='1mqa' size='340' side='right'caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mqa' size='340' side='right'caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mq8\|1mq8]], [[1mq9\|1mq9]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mq8\|1mq8]], [[1mq9\|1mq9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [~~http~~://pdbe.org/1mqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [https://pdbe.org/1mqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [https://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.	+	[[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:40, 2 December 2020

2020-12-02T08:40:22Z

←Older revision		Revision as of 08:40, 2 December 2020
Line 1:		Line 1:

	==Crystal structure of high affinity alphaL I domain in the absence of ligand or metal==		==Crystal structure of high affinity alphaL I domain in the absence of ligand or metal==
-	<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1mqa' size='340' side='right'caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mq8\|1mq8]], [[1mq9\|1mq9]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://pdbe.org/1mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://pdbe.org/1mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Integrin 3D structures\|Integrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dong, Y]]		[[Category: Dong, Y]]
	[[Category: Jun, C D]]		[[Category: Jun, C D]]

OCA at 10:04, 25 October 2017

2017-10-25T10:04:46Z

←Older revision		Revision as of 10:04, 25 October 2017
Line 1:		Line 1:
		+
	==Crystal structure of high affinity alphaL I domain in the absence of ligand or metal==		==Crystal structure of high affinity alphaL I domain in the absence of ligand or metal==
	<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://pdbe.org/1mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://pdbe.org/1mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mqa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Integrin\|Integrin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:42, 11 September 2015

2015-09-11T15:42:55Z

←Older revision		Revision as of 15:42, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://pdbe.org/1mqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1mqa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dong, Y]]		[[Category: Dong, Y]]
	[[Category: Jun, C D]]		[[Category: Jun, C D]]

OCA at 18:33, 25 December 2014

2014-12-25T18:33:02Z

←Older revision		Revision as of 18:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQA FirstGlance]. <br>		<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dong, Y.]]	+	[[Category: Dong, Y]]
-	[[Category: Jun, C D.]]	+	[[Category: Jun, C D]]
-	[[Category: Liu, J H.]]	+	[[Category: Liu, J H]]
-	[[Category: Shimaoka, T.]]	+	[[Category: Shimaoka, T]]
-	[[Category: Springer, T A.]]	+	[[Category: Springer, T A]]
-	[[Category: Takagi, J.]]	+	[[Category: Takagi, J]]
-	[[Category: Wang, J H.]]	+	[[Category: Wang, J H]]
-	[[Category: Xiao, T.]]	+	[[Category: Xiao, T]]
-	[[Category: Yang, Y.]]	+	[[Category: Yang, Y]]
-	[[Category: Zhang, R.]]	+	[[Category: Zhang, R]]
	[[Category: Designed disulfide bridge]]		[[Category: Designed disulfide bridge]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 17:34, 28 September 2014

2014-09-28T17:34:47Z

←Older revision		Revision as of 17:34, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1mqa.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of high affinity alphaL I domain in the absence of ligand or metal==
		+	<StructureSection load='1mqa' size='340' side='right' caption='[[1mqa]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MQA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mq8\|1mq8]], [[1mq9\|1mq9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LFA-1 (AlphaLbeta2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mqa RCSB], [http://www.ebi.ac.uk/pdbsum/1mqa PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/1mqa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of the I domain of integrin alpha L beta 2 bound to the Ig superfamily ligand ICAM-1 reveals the open ligand binding conformation and the first example of an integrin-IgSF interface. The I domain Mg2+ directly coordinates Glu-34 of ICAM-1, and a dramatic swing of I domain residue Glu-241 enables a critical salt bridge. Liganded and unliganded structures for both high- and intermediate-affinity mutant I domains reveal that ligand binding can induce conformational change in the alpha L I domain and that allosteric signals can convert the closed conformation to intermediate or open conformations without ligand binding. Pulling down on the C-terminal alpha 7 helix with introduced disulfide bonds ratchets the beta 6-alpha 7 loop into three different positions in the closed, intermediate, and open conformations, with a progressive increase in affinity.

-	~~{{STRUCTURE_1mqa\| PDB=1mqa \| SCENE= }}~~	+	Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.,Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA Cell. 2003 Jan 10;112(1):99-111. PMID:12526797<ref>PMID:12526797</ref>

-	~~===Crystal structure~~ of ~~high affinity alphaL I domain in~~ the ~~absence of ligand or metal===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12526797}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1mqa]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA].~~	+

	==See Also==		==See Also==
	*[[Integrin\|Integrin]]		*[[Integrin\|Integrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012526797<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dong, Y.]]		[[Category: Dong, Y.]]

OCA: Protected "1mqa" [edit=sysop:move=sysop]

2012-10-20T20:02:30Z

Protected "1mqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:02, 20 October 2012

OCA at 20:02, 20 October 2012

2012-10-20T20:02:27Z

←Older revision		Revision as of 20:02, 20 October 2012
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-	{{Seed}}
	[[Image:1mqa.png\|left\|200px]]		[[Image:1mqa.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1mqa", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1mqa\| PDB=1mqa \| SCENE= }}		{{STRUCTURE_1mqa\| PDB=1mqa \| SCENE= }}

	===Crystal structure of high affinity alphaL I domain in the absence of ligand or metal===		===Crystal structure of high affinity alphaL I domain in the absence of ligand or metal===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12526797}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12526797 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12526797}}		{{ABSTRACT_PUBMED_12526797}}

	==About this Structure==		==About this Structure==
-	~~1MQA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA].	+	[[1mqa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA].
		+
		+	==See Also==
		+	*[[Integrin\|Integrin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12526797~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012526797</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dong, Y.]]		[[Category: Dong, Y.]]
Line 36:		Line 27:
	[[Category: Zhang, R.]]		[[Category: Zhang, R.]]
	[[Category: Designed disulfide bridge]]		[[Category: Designed disulfide bridge]]
		+	[[Category: Immune system]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:35:38 2009''

OCA at 00:35, 18 February 2009

2009-02-18T00:35:42Z

←Older revision		Revision as of 00:35, 18 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	1MQA is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA].	+	1MQA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MQA OCA].

	==Reference==		==Reference==
-	Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation., Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA, Cell. 2003 Jan 10;112(1):99-111. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12526797 12526797]~~	+	<ref group="xtra">PMID:12526797</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Dong, Y.]]		[[Category: Dong, Y.]]
	[[Category: Jun, C D.]]		[[Category: Jun, C D.]]
Line 39:		Line 38:
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 00~~:52:~~04 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:35:38 2009''