1ncw - Revision history

OCA at 09:19, 16 August 2023

2023-08-16T09:19:01Z

←Older revision		Revision as of 09:19, 16 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[1nd0\|1nd0]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [https://pdbe.org/1ncw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [https://www.ebi.ac.uk/pdbsum/1ncw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [https://pdbe.org/1ncw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [https://www.ebi.ac.uk/pdbsum/1ncw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q58EU8_MOUSE Q58EU8_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhu, X]]	+	[[Category: Zhu X]]
-	~~[[Category: Catalytic antibody]]~~	+
-	~~[[Category: Cationic cyclization reaction]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 09:34, 5 May 2021

2021-05-05T09:34:06Z

←Older revision		Revision as of 09:34, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='1ncw' size='340' side='right'caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1ncw' size='340' side='right'caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NCW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NCW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nd0\|1nd0]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [~~http~~://pdbe.org/1ncw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ncw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [https://pdbe.org/1ncw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [https://www.ebi.ac.uk/pdbsum/1ncw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:34, 31 July 2019

2019-07-31T07:34:45Z

←Older revision		Revision as of 07:34, 31 July 2019
Line 1:		Line 1:

	==Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid==		==Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid==
-	<StructureSection load='1ncw' size='340' side='right' caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='1ncw' size='340' side='right'caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCW FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1ncw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1ncw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]

OCA at 10:22, 25 October 2017

2017-10-25T10:22:33Z

←Older revision		Revision as of 10:22, 25 October 2017
Line 1:		Line 1:
		+
	==Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid==		==Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid==
	<StructureSection load='1ncw' size='340' side='right' caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='1ncw' size='340' side='right' caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://pdbe.org/1ncw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://pdbe.org/1ncw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ncw ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ncw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:34, 12 September 2015

2015-09-12T01:34:26Z

←Older revision		Revision as of 01:34, 12 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://pdbe.org/1ncw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ncw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:42, 5 January 2015

2015-01-05T15:42:17Z

←Older revision		Revision as of 15:42, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
-	[[Category: Zhu, X.]]	+	[[Category: Zhu, X]]
	[[Category: Catalytic antibody]]		[[Category: Catalytic antibody]]
	[[Category: Cationic cyclization reaction]]		[[Category: Cationic cyclization reaction]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 16:52, 28 September 2014

2014-09-28T16:52:14Z

←Older revision		Revision as of 16:52, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1ncw.~~png~~\|~~left~~\|200px]]	+	==Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid==
		+	<StructureSection load='1ncw' size='340' side='right' caption='[[1ncw]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nd0\|1nd0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ncw RCSB], [http://www.ebi.ac.uk/pdbsum/1ncw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/1ncw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody 4C6 efficiently catalyzes a cationic cyclization reaction. Crystal structures of the antibody 4C6 Fab in complex with benzoic acid and in complex with its eliciting hapten were determined to 1.30A and 2.45A resolution, respectively. These crystal structures, together with computational analysis, have elucidated a possible mechanism for the monocyclization reaction. The hapten complex revealed a combining site pocket with high shape complementarity to the hapten. This active site cleft is dominated by aromatic residues that shield the highly reactive carbocation intermediates from solvent and stabilize the carbocation intermediates through cation-pi interactions. Modeling of an acyclic olefinic sulfonate ester substrate and the transition state (TS) structures shows that the chair-like transition state is favored, and trapping by water directly produces trans-2-(dimethylphenylsilyl)-cyclohexanol, whereas the less favored boat-like transition state leads to cyclohexene. The only significant change observed upon hapten binding is a side-chain rotation of Trp(L89), which reorients to form the base of the combining site. Intriguingly, a benzoic acid molecule was sequestered in the combining site of the unliganded antibody. The 4C6 active site was compared to that observed in a previously reported tandem cyclization antibody 19A4 hapten complex. These cationic cyclization antibodies exhibit convergent structural features with terpenoid cyclases that appear to be important for catalysis.

-	~~{{STRUCTURE_1ncw\| PDB=1ncw \| SCENE= }}~~	+	Structural basis for antibody catalysis of a cationic cyclization reaction.,Zhu X, Heine A, Monnat F, Houk KN, Janda KD, Wilson IA J Mol Biol. 2003 May 23;329(1):69-83. PMID:12742019<ref>PMID:12742019</ref>

-	~~===Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_12742019}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1ncw~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:012742019<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]

OCA: Protected "1ncw" [edit=sysop:move=sysop]

2012-12-05T19:57:15Z

Protected "1ncw" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:57, 5 December 2012

OCA at 19:57, 5 December 2012

2012-12-05T19:57:10Z

←Older revision		Revision as of 19:57, 5 December 2012
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-	{{Seed}}
	[[Image:1ncw.png\|left\|200px]]		[[Image:1ncw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1ncw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_1ncw\| PDB=1ncw \| SCENE= }}		{{STRUCTURE_1ncw\| PDB=1ncw \| SCENE= }}

	===Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid===		===Cationic Cyclization Antibody 4C6 in Complex with Benzoic Acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12742019}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_12742019}}		{{ABSTRACT_PUBMED_12742019}}

	==About this Structure==		==About this Structure==
-	~~1NCW~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA].	+	[[1ncw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12742019~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012742019</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
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	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:15:37 2009''

OCA at 07:15, 18 February 2009

2009-02-18T07:15:38Z

←Older revision		Revision as of 07:15, 18 February 2009
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	==About this Structure==		==About this Structure==
-	1NCW is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA].	+	1NCW is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCW OCA].

	==Reference==		==Reference==
-	~~Structural basis for antibody catalysis of a cationic cyclization reaction., Zhu X, Heine A, Monnat F, Houk KN, Janda KD, Wilson IA, J Mol Biol. 2003 May 23;329(1):69-83.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/12742019 12742019]~~	+	<ref group="xtra">PMID:12742019</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
	[[Category: Zhu, X.]]		[[Category: Zhu, X.]]
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	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 15~~:30:~~12 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:15:37 2009''