1nld - Revision history

OCA at 08:50, 10 April 2024

2024-04-10T08:50:58Z

←Older revision

Revision as of 08:50, 10 April 2024

OCA at 07:04, 25 August 2021

2021-08-25T07:04:13Z

←Older revision		Revision as of 07:04, 25 August 2021
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	<StructureSection load='1nld' size='340' side='right'caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1nld' size='340' side='right'caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NLD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [~~http~~://pdbe.org/1nld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nld ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [https://pdbe.org/1nld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [https://www.ebi.ac.uk/pdbsum/1nld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nld ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 18:40, 20 November 2019

2019-11-20T18:40:09Z

←Older revision		Revision as of 18:40, 20 November 2019
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	==FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1==		==FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1==
-	<StructureSection load='1nld' size='340' side='right' caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1nld' size='340' side='right'caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1nld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nld" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Beauchamp, J C]]		[[Category: Beauchamp, J C]]

OCA at 07:27, 7 February 2018

2018-02-07T07:27:35Z

←Older revision		Revision as of 07:27, 7 February 2018
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		+
	==FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1==		==FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1==
	<StructureSection load='1nld' size='340' side='right' caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1nld' size='340' side='right' caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://pdbe.org/1nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://pdbe.org/1nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nld ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nld_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nld_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 1nld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nld" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:35, 8 February 2016

2016-02-08T20:35:48Z

←Older revision		Revision as of 20:35, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nld ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:10, 10 September 2015

2015-09-10T15:10:57Z

←Older revision		Revision as of 15:10, 10 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://pdbe.org/1nld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nld" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:59, 5 January 2015

2015-01-05T15:59:00Z

←Older revision		Revision as of 15:59, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Beauchamp, J C.]]	+	[[Category: Beauchamp, J C]]
-	[[Category: Davies, C.]]	+	[[Category: Davies, C]]
-	[[Category: Emery, D.]]	+	[[Category: Emery, D]]
-	[[Category: Muirhead, H.]]	+	[[Category: Muirhead, H]]
-	[[Category: Rawas, A.]]	+	[[Category: Rawas, A]]
	[[Category: Fab fragment]]		[[Category: Fab fragment]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 17:12, 28 September 2014

2014-09-28T17:12:06Z

←Older revision		Revision as of 17:12, 28 September 2014
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-	[[~~Image~~:1nld.~~png\|left~~\|200px]]	+	==FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1==
		+	<StructureSection load='1nld' size='340' side='right' caption='[[1nld]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NLD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nld OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nld RCSB], [http://www.ebi.ac.uk/pdbsum/1nld PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nl/1nld_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of a Fab fragment of a monoclonal antibody (1583) that neutralizes a broad range of HIV-1 isolates has been solved by X-ray crystallography. This antibody is directed against a poliovirus/HIV-I chimaera which presents a conserved epitope of the envelope protein gp41. Crystals of 1583 were obtained in the space group P2(1)2(1)2(1) and the structure solved by molecular replacement. The model has been refined against all data in the range 10-2.9 A to a final crystallographic R factor of 0.198. The antigen-binding site features a well defined groove, typical of antibodies that bind to small antigens, created in part by a relatively short CDR H3. The variable regions of 1583 were sequenced and, given the hydrophilic nature of the epitope, revealed a surprising lack of charged residues in the CDR's. However, the antigen-binding cleft is indeed very polar, due in part to the presence of two charged residues that emanate from outside the recognized CDR's.

-	~~{{STRUCTURE_1nld\| PDB=1nld \| SCENE= }}~~	+	Structure of the Fab fragment from a neutralizing monoclonal antibody directed against an epitope of gp41 from HIV-1.,Davies C, Beauchamp JC, Emery D, Rawas A, Muirhead H Acta Crystallogr D Biol Crystallogr. 1997 Mar 1;53(Pt 2):186-94. PMID:15299953<ref>PMID:15299953</ref>

-	~~===FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15299953}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1nld]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA].~~	+

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015299953<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Beauchamp, J C.]]		[[Category: Beauchamp, J C.]]

OCA at 11:24, 20 October 2012

2012-10-20T11:24:04Z

←Older revision		Revision as of 11:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1nld]] is a 2 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA].	+	[[1nld]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NLD OCA].

	==See Also==		==See Also==

OCA: Protected "1nld" [edit=sysop:move=sysop]

2012-07-26T05:14:19Z

Protected "1nld" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:14, 26 July 2012