1nqc - Revision history

OCA at 09:24, 16 August 2023

2023-08-16T09:24:21Z

←Older revision		Revision as of 09:24, 16 August 2023
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	<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C4P:N~~-[~~(1R)-2-(BENZYLSULFANYL)-~~1~~-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1npz\|1npz]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>~~[~~https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S~~]~~, with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~4~~.22.27 3.4.22.27]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [https://pdbe.org/1nqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [https://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [https://pdbe.org/1nqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [https://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.	+	[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cathepsin S]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ammirati, M]]	+	[[Category: Ammirati M]]
-	[[Category: Cygler, M]]	+	[[Category: Cygler M]]
-	[[Category: Danley~~, D E~~]]	+	[[Category: Danley DE]]
-	[[Category: Griffor~~, M C~~]]	+	[[Category: Griffor MC]]
-	[[Category: Kamath~~, A V~~]]	+	[[Category: Kamath AV]]
-	[[Category: Laird~~, E R~~]]	+	[[Category: Laird ER]]
-	[[Category: Menard, R]]	+	[[Category: Menard R]]
-	[[Category: Pauly~~, T A~~]]	+	[[Category: Pauly TA]]
-	[[Category: Rath~~, V L~~]]	+	[[Category: Rath VL]]
-	[[Category: Sivaraman, J]]	+	[[Category: Sivaraman J]]
-	[[Category: Sulea, T]]	+	[[Category: Sulea T]]
-	[[Category: Wang~~, I K]]~~	+	[[Category: Wang IK]]
-	~~[[Category: Antigen presentation]]~~	+
-	~~[[Category: Binding specificity]]~~	+
-	~~[[Category: Cysteine protease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Structural plasticity]]~~	+
-	~~[[Category: Structure-based design~~]]	+

OCA at 08:56, 21 April 2021

2021-04-21T08:56:52Z

←Older revision		Revision as of 08:56, 21 April 2021
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	<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1npz\|1npz]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [~~http~~://pdbe.org/1nqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [https://pdbe.org/1nqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [https://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.	+	[[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:36, 17 July 2019

2019-07-17T13:36:16Z

←Older revision		Revision as of 13:36, 17 July 2019
Line 1:		Line 1:

	==Crystal structures of Cathepsin S inhibitor complexes==		==Crystal structures of Cathepsin S inhibitor complexes==
-	<StructureSection load='1nqc' size='340' side='right' caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1nqc' size='340' side='right'caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1nqc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nqc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ammirati, M]]		[[Category: Ammirati, M]]
	[[Category: Cygler, M]]		[[Category: Cygler, M]]

OCA at 09:42, 12 October 2017

2017-10-12T09:42:40Z

←Older revision		Revision as of 09:42, 12 October 2017
Line 1:		Line 1:
		+
	==Crystal structures of Cathepsin S inhibitor complexes==		==Crystal structures of Cathepsin S inhibitor complexes==
	<StructureSection load='1nqc' size='340' side='right' caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1nqc' size='340' side='right' caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://pdbe.org/1nqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://pdbe.org/1nqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nqc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1nqc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1nqc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cathepsin\|Cathepsin]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ammirati, M]]		[[Category: Ammirati, M]]
	[[Category: Cygler, M]]		[[Category: Cygler, M]]

OCA at 14:04, 11 September 2015

2015-09-11T14:04:53Z

←Older revision		Revision as of 14:04, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://pdbe.org/1nqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nqc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:28, 25 December 2014

2014-12-25T17:28:26Z

←Older revision		Revision as of 17:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ammirati, M.]]	+	[[Category: Ammirati, M]]
-	[[Category: Cygler, M.]]	+	[[Category: Cygler, M]]
-	[[Category: Danley, D E.]]	+	[[Category: Danley, D E]]
-	[[Category: Griffor, M C.]]	+	[[Category: Griffor, M C]]
-	[[Category: Kamath, A V.]]	+	[[Category: Kamath, A V]]
-	[[Category: Laird, E R.]]	+	[[Category: Laird, E R]]
-	[[Category: Menard, R.]]	+	[[Category: Menard, R]]
-	[[Category: Pauly, T A.]]	+	[[Category: Pauly, T A]]
-	[[Category: Rath, V L.]]	+	[[Category: Rath, V L]]
-	[[Category: Sivaraman, J.]]	+	[[Category: Sivaraman, J]]
-	[[Category: Sulea, T.]]	+	[[Category: Sulea, T]]
-	[[Category: Wang, I K.]]	+	[[Category: Wang, I K]]
	[[Category: Antigen presentation]]		[[Category: Antigen presentation]]
	[[Category: Binding specificity]]		[[Category: Binding specificity]]

OCA at 15:46, 28 September 2014

2014-09-28T15:46:23Z

←Older revision		Revision as of 15:46, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1nqc.~~png~~\|~~left~~\|200px]]	+	==Crystal structures of Cathepsin S inhibitor complexes==
		+	<StructureSection load='1nqc' size='340' side='right' caption='[[1nqc]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NQC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C4P:N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE'>C4P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1npz\|1npz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nqc RCSB], [http://www.ebi.ac.uk/pdbsum/1nqc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cathepsin S, a lysosomal cysteine protease of the papain superfamily, has been implicated in the preparation of MHC class II alphabeta-heterodimers for antigen presentation to CD4+ T lymphocytes and is considered a potential target for autoimmune-disease therapy. Selective inhibition of this enzyme may be therapeutically useful for attenuating the hyperimmune responses in a number of disorders. We determined the three-dimensional crystal structures of human cathepsin S in complex with potent covalent inhibitors, the aldehyde inhibitor 4-morpholinecarbonyl-Phe-(S-benzyl)Cys-Psi(CH=O), and the vinyl sulfone irreversible inhibitor 4-morpholinecarbonyl-Leu-Hph-Psi(CH=CH-SO(2)-phenyl) at resolutions of 1.8 and 2.0 A, respectively. In the structure of the cathepsin S-aldehyde complex, the tetrahedral thiohemiacetal adduct favors the S-configuration, in which the oxygen atom interacts with the imidazole group of the active site His164 rather than with the oxyanion hole. The present structures provide a detailed map of noncovalent intermolecular interactions established in the substrate-binding subsites S3 to S1' of cathepsin S. In the S2 pocket, which is the binding affinity hot spot of cathepsin S, the Phe211 side chain can assume two stable conformations that accommodate either the P2-Leu or a bulkier P2-Phe side chain. This structural plasticity of the S2 pocket in cathepsin S explains the selective inhibition of cathepsin S over cathepsin K afforded by inhibitors with the P2-Phe side chain. Comparison with the structures of cathepsins K, V, and L allows delineation of local intermolecular contacts that are unique to cathepsin S.

-	~~{{STRUCTURE_1nqc\| PDB=1nqc \| SCENE= }}~~	+	Specificity determinants of human cathepsin s revealed by crystal structures of complexes.,Pauly TA, Sulea T, Ammirati M, Sivaraman J, Danley DE, Griffor MC, Kamath AV, Wang IK, Laird ER, Seddon AP, Menard R, Cygler M, Rath VL Biochemistry. 2003 Mar 25;42(11):3203-13. PMID:12641451<ref>PMID:12641451</ref>

-	~~===Crystal structures~~ of ~~Cathepsin~~ S ~~inhibitor complexes===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12641451}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1nqc]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA].~~	+

	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012641451<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:26, 20 October 2012

2012-10-20T19:26:53Z

←Older revision		Revision as of 19:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1nqc]] is a 1 chain structure ~~of [[Cathepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA].	+	[[1nqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQC OCA].

	==See Also==		==See Also==

OCA at 07:23, 27 July 2012

2012-07-27T07:23:14Z

←Older revision		Revision as of 07:23, 27 July 2012
Line 1:		Line 1:
	[[Image:1nqc.png\|left\|200px]]		[[Image:1nqc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1nqc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1nqc\| PDB=1nqc \| SCENE= }}		{{STRUCTURE_1nqc\| PDB=1nqc \| SCENE= }}

	===Crystal structures of Cathepsin S inhibitor complexes===		===Crystal structures of Cathepsin S inhibitor complexes===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12641451}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12641451 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12641451}}		{{ABSTRACT_PUBMED_12641451}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cathepsin]]	+	*[[Cathepsin\|Cathepsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12641451~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012641451</ref><references group="xtra"/>
	[[Category: Cathepsin S]]		[[Category: Cathepsin S]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "1nqc" [edit=sysop:move=sysop]

2010-12-27T00:33:53Z

Protected "1nqc" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:33, 27 December 2010