1nr2 - Revision history

OCA at 06:09, 3 April 2024

2024-04-03T06:09:15Z

←Older revision		Revision as of 06:09, 3 April 2024
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	<StructureSection load='1nr2' size='340' side='right'caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='1nr2' size='340' side='right'caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max~~-~~height: 3em;'>~~[[~~1nr4~~\|~~1nr4~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.18Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [https://pdbe.org/1nr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [https://www.ebi.ac.uk/pdbsum/1nr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [https://pdbe.org/1nr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [https://www.ebi.ac.uk/pdbsum/1nr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CCL17_HUMAN CCL17_HUMAN]] Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.<ref>PMID:10540332</ref>	+	[https://www.uniprot.org/uniprot/CCL17_HUMAN CCL17_HUMAN] Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.<ref>PMID:10540332</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nr2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nr2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Thymus and activation-regulated chemokine (TARC) is a CC chemokine that is mainly expressed in the thymus. TARC interacts primarily with the CCR4 receptor and to a lesser extent with the CCR8 receptor. The structures of TARC have been solved by molecular replacement in two space groups, triclinic (P1) and tetragonal (P4(1)), and refined to resolutions of 1.72 and 2.1 A, respectively, with R factors of 19.8% (R(free) = 24.1%) and 19.8% (R(free) = 27.7%), respectively. The search model originated from the crystal structure of another chemokine, RANTES, and proved to be only modestly similar to the refined structure of TARC. Whereas the tetragonal structure was easily solved using the program AMoRe, solution of the triclinic structure proved to be quite challenging and was obtained by combining the results from four different molecular-replacement programs (AMoRe, CNS, BEAST and EPMR), with subsequent extension of the gathered information. The tertiary structure of TARC is similar to that of other CC chemokines, with a three-stranded antiparallel beta-sheet flanked by a C-terminal helix. Both quaternary structures consist of dimers, which in the triclinic crystals pack further into tetramers. The TARC dimers are similar to those observed previously in the crystal structures of both MCP-1 and RANTES.
-
-	Structures of thymus and activation-regulated chemokine (TARC).,Asojo OA, Boulegue C, Hoover DM, Lu W, Lubkowski J Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1165-73. Epub 2003, Jun 27. PMID:12832759<ref>PMID:12832759</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1nr2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Asojo~~, O A~~]]	+	[[Category: Asojo OA]]
-	[[Category: Boulegue, C]]	+	[[Category: Boulegue C]]
-	[[Category: Hoover~~, D M~~]]	+	[[Category: Hoover DM]]
-	[[Category: Lu, W]]	+	[[Category: Lu W]]
-	[[Category: Lubkowski, J]]	+	[[Category: Lubkowski J]]
-	~~[[Category: Cc-chemokine]]~~	+
-	~~[[Category: Chemokine]]~~	+
-	~~[[Category: Chemotaxis]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Tarc~~]]	+

OCA at 07:05, 25 August 2021

2021-08-25T07:05:31Z

←Older revision		Revision as of 07:05, 25 August 2021
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	<StructureSection load='1nr2' size='340' side='right'caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='1nr2' size='340' side='right'caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nr4\|1nr4]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [~~http~~://pdbe.org/1nr2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1nr2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [https://pdbe.org/1nr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [https://www.ebi.ac.uk/pdbsum/1nr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CCL17_HUMAN CCL17_HUMAN]] Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.<ref>PMID:10540332</ref>	+	[[https://www.uniprot.org/uniprot/CCL17_HUMAN CCL17_HUMAN]] Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.<ref>PMID:10540332</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:17, 20 November 2019

2019-11-20T18:17:43Z

←Older revision		Revision as of 18:17, 20 November 2019
Line 1:		Line 1:

	==High resolution crystal structures of thymus and activation-regulated chemokine==		==High resolution crystal structures of thymus and activation-regulated chemokine==
-	<StructureSection load='1nr2' size='340' side='right' caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='1nr2' size='340' side='right'caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Asojo, O A]]		[[Category: Asojo, O A]]
	[[Category: Boulegue, C]]		[[Category: Boulegue, C]]

OCA at 18:38, 24 January 2018

2018-01-24T18:38:56Z

←Older revision		Revision as of 18:38, 24 January 2018
Line 1:		Line 1:
		+
	==High resolution crystal structures of thymus and activation-regulated chemokine==		==High resolution crystal structures of thymus and activation-regulated chemokine==
	<StructureSection load='1nr2' size='340' side='right' caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='1nr2' size='340' side='right' caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://pdbe.org/1nr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://pdbe.org/1nr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nr2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nr2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nr2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:24, 7 February 2016

2016-02-07T06:24:28Z

←Older revision		Revision as of 06:24, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nr2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:42, 9 September 2015

2015-09-09T22:42:22Z

←Older revision		Revision as of 22:42, 9 September 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://pdbe.org/1nr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1nr2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:36, 24 December 2014

2014-12-24T08:36:27Z

←Older revision		Revision as of 08:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCL17_HUMAN CCL17_HUMAN]] Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.<ref>PMID:10540332</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Asojo, O A.]]	+	[[Category: Asojo, O A]]
-	[[Category: Boulegue, C.]]	+	[[Category: Boulegue, C]]
-	[[Category: Hoover, D M.]]	+	[[Category: Hoover, D M]]
-	[[Category: Lu, W.]]	+	[[Category: Lu, W]]
-	[[Category: Lubkowski, J.]]	+	[[Category: Lubkowski, J]]
	[[Category: Cc-chemokine]]		[[Category: Cc-chemokine]]
	[[Category: Chemokine]]		[[Category: Chemokine]]

OCA at 14:18, 28 September 2014

2014-09-28T14:18:13Z

←Older revision		Revision as of 14:18, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1nr2.~~png~~\|~~left~~\|200px]]	+	==High resolution crystal structures of thymus and activation-regulated chemokine==
		+	<StructureSection load='1nr2' size='340' side='right' caption='[[1nr2]], [[Resolution\|resolution]] 2.18Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NR2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nr4\|1nr4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nr2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nr2 RCSB], [http://www.ebi.ac.uk/pdbsum/1nr2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/1nr2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thymus and activation-regulated chemokine (TARC) is a CC chemokine that is mainly expressed in the thymus. TARC interacts primarily with the CCR4 receptor and to a lesser extent with the CCR8 receptor. The structures of TARC have been solved by molecular replacement in two space groups, triclinic (P1) and tetragonal (P4(1)), and refined to resolutions of 1.72 and 2.1 A, respectively, with R factors of 19.8% (R(free) = 24.1%) and 19.8% (R(free) = 27.7%), respectively. The search model originated from the crystal structure of another chemokine, RANTES, and proved to be only modestly similar to the refined structure of TARC. Whereas the tetragonal structure was easily solved using the program AMoRe, solution of the triclinic structure proved to be quite challenging and was obtained by combining the results from four different molecular-replacement programs (AMoRe, CNS, BEAST and EPMR), with subsequent extension of the gathered information. The tertiary structure of TARC is similar to that of other CC chemokines, with a three-stranded antiparallel beta-sheet flanked by a C-terminal helix. Both quaternary structures consist of dimers, which in the triclinic crystals pack further into tetramers. The TARC dimers are similar to those observed previously in the crystal structures of both MCP-1 and RANTES.

-	~~{{STRUCTURE_1nr2\| PDB=1nr2 \| SCENE= }}~~	+	Structures of thymus and activation-regulated chemokine (TARC).,Asojo OA, Boulegue C, Hoover DM, Lu W, Lubkowski J Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1165-73. Epub 2003, Jun 27. PMID:12832759<ref>PMID:12832759</ref>

-	~~===High resolution crystal structures~~ of ~~thymus and activation-regulated chemokine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12832759}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1nr2]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1NR2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012832759<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Asojo, O A.]]		[[Category: Asojo, O A.]]
	[[Category: Boulegue, C.]]		[[Category: Boulegue, C.]]

OCA: Protected "1nr2" [edit=sysop:move=sysop]

2012-12-05T19:44:05Z

Protected "1nr2" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:44, 5 December 2012

OCA at 19:44, 5 December 2012

2012-12-05T19:44:02Z

←Older revision		Revision as of 19:44, 5 December 2012
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-	{{Seed}}
	[[Image:1nr2.png\|left\|200px]]		[[Image:1nr2.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1nr2\| PDB=1nr2 \| SCENE= }}		{{STRUCTURE_1nr2\| PDB=1nr2 \| SCENE= }}

	===High resolution crystal structures of thymus and activation-regulated chemokine===		===High resolution crystal structures of thymus and activation-regulated chemokine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12832759}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_12832759}}		{{ABSTRACT_PUBMED_12832759}}

	==About this Structure==		==About this Structure==
-	~~1NR2~~ is a 2 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA].	+	[[1nr2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NR2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12832759~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012832759</ref><references group="xtra"/>
	[[Category: Asojo, O A.]]		[[Category: Asojo, O A.]]
	[[Category: Boulegue, C.]]		[[Category: Boulegue, C.]]
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	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Tarc]]		[[Category: Tarc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:56:32 2009''