1oby - Revision history

OCA at 12:34, 13 December 2023

2023-12-13T12:34:25Z

←Older revision		Revision as of 12:34, 13 December 2023
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	<StructureSection load='1oby' size='340' side='right'caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1oby' size='340' side='right'caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [https://pdbe.org/1oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [https://www.ebi.ac.uk/pdbsum/1oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oby ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [https://pdbe.org/1oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [https://www.ebi.ac.uk/pdbsum/1oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~SDC4_HUMAN SDC4_HUMAN~~]~~] Cell~~ surface ~~proteoglycan that bears heparan sulfate~~.	+	[https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 1oby" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oby" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of syntenin\|3D structures of syntenin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cooper~~, D R~~]]	+	[[Category: Cooper DR]]
-	[[Category: Derewenda, U]]	+	[[Category: Derewenda U]]
-	[[Category: Derewenda~~, Z S~~]]	+	[[Category: Derewenda ZS]]
-	[[Category: Devedjiev, Y]]	+	[[Category: Devedjiev Y]]
-	[[Category: Kang~~, B S]]~~	+	[[Category: Kang BS]]
-	~~[[Category: Adhesion-complex]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Nuclear protein]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Signal transduction~~]]	+

OCA at 09:51, 21 July 2021

2021-07-21T09:51:35Z

←Older revision		Revision as of 09:51, 21 July 2021
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	<StructureSection load='1oby' size='340' side='right'caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1oby' size='340' side='right'caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [~~http~~://pdbe.org/1oby PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oby PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oby ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [https://pdbe.org/1oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [https://www.ebi.ac.uk/pdbsum/1oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SDC4_HUMAN SDC4_HUMAN]] Cell surface proteoglycan that bears heparan sulfate.	+	[[https://www.uniprot.org/uniprot/SDC4_HUMAN SDC4_HUMAN]] Cell surface proteoglycan that bears heparan sulfate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:39, 10 May 2019

2019-05-10T11:39:48Z

←Older revision		Revision as of 11:39, 10 May 2019
Line 1:		Line 1:

	==Crystal structure of the complex of PDZ2 of syntenin with a syndecan-4 peptide.==		==Crystal structure of the complex of PDZ2 of syntenin with a syndecan-4 peptide.==
-	<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='1oby' size='340' side='right'caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]
	[[Category: Derewenda, U]]		[[Category: Derewenda, U]]

OCA at 07:06, 7 February 2018

2018-02-07T07:06:58Z

←Older revision		Revision as of 07:06, 7 February 2018
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-	==~~CRYSTAL STRUCTURE OF THE COMPLEX OF~~ PDZ2 ~~OF SYNTENIN WITH A SYNDECAN~~-4 ~~PEPTIDE~~.==	+
		+	==Crystal structure of the complex of PDZ2 of syntenin with a syndecan-4 peptide.==
	<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://pdbe.org/1oby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://pdbe.org/1oby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oby ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1oby_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1oby_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:38, 10 February 2016

2016-02-10T07:38:03Z

←Older revision		Revision as of 07:38, 10 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oby ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:46, 11 September 2015

2015-09-11T06:46:05Z

←Older revision		Revision as of 06:46, 11 September 2015
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	<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://pdbe.org/1oby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oby" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cooper, D R]]		[[Category: Cooper, D R]]
	[[Category: Derewenda, U]]		[[Category: Derewenda, U]]

OCA at 12:46, 25 December 2014

2014-12-25T12:46:27Z

←Older revision		Revision as of 12:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SDC4_HUMAN SDC4_HUMAN]] Cell surface proteoglycan that bears heparan sulfate.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cooper, D R.]]	+	[[Category: Cooper, D R]]
-	[[Category: Derewenda, U.]]	+	[[Category: Derewenda, U]]
-	[[Category: Derewenda, Z S.]]	+	[[Category: Derewenda, Z S]]
-	[[Category: Devedjiev, Y.]]	+	[[Category: Devedjiev, Y]]
-	[[Category: Kang, B S.]]	+	[[Category: Kang, B S]]
	[[Category: Adhesion-complex]]		[[Category: Adhesion-complex]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 14:54, 28 September 2014

2014-09-28T14:54:49Z

←Older revision		Revision as of 14:54, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oby.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.==
		+	<StructureSection load='1oby' size='340' side='right' caption='[[1oby]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OBY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1nte\|1nte]], [[1obx\|1obx]], [[1obz\|1obz]], [[1ejp\|1ejp]], [[1ejq\|1ejq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oby RCSB], [http://www.ebi.ac.uk/pdbsum/1oby PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/1oby_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystal structures of the PDZ2 domain of the scaffolding protein syntenin, both unbound and in complexes with peptides derived from C termini of IL5 receptor (alpha chain) and syndecan, reveal the molecular roots of syntenin's degenerate specificity. Three distinct binding sites (S(0), S(-1), and S(-2)), with affinities for hydrophobic side chains, function in a combinatorial way: S(-1) and S(-2) act together to bind syndecan, while S(0) and S(-1) are involved in the binding of IL5Ralpha. Neither mode of interaction is consistent with the prior classification scheme, which defined the IL5Ralpha interaction as class I (-S/T-X-phi) and the syndecan interaction as class II (-phi-X-phi). These results, in conjunction with other emerging structural data on PDZ domains, call for a revision of their classification and of the existing model of their mechanism.

-	~~{{STRUCTURE_1oby\| PDB=1oby \| SCENE= }}~~	+	Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm.,Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS Structure. 2003 Jul;11(7):845-53. PMID:12842047<ref>PMID:12842047</ref>

-	~~===CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12842047}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1oby]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012842047<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cooper, D R.]]		[[Category: Cooper, D R.]]

OCA: Protected "1oby" [edit=sysop:move=sysop]

2012-12-12T21:51:52Z

Protected "1oby" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:51, 12 December 2012

OCA at 21:51, 12 December 2012

2012-12-12T21:51:49Z

←Older revision		Revision as of 21:51, 12 December 2012
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	[[Image:1oby.png\|left\|200px]]		[[Image:1oby.png\|left\|200px]]

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	===CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.===		===CRYSTAL STRUCTURE OF THE COMPLEX OF PDZ2 OF SYNTENIN WITH A SYNDECAN-4 PEPTIDE.===

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	{{ABSTRACT_PUBMED_12842047}}		{{ABSTRACT_PUBMED_12842047}}

	==About this Structure==		==About this Structure==
-	~~1OBY~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA].	+	[[1oby]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OBY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12842047~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012842047</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cooper, D R.]]		[[Category: Cooper, D R.]]
Line 30:		Line 18:
	[[Category: Devedjiev, Y.]]		[[Category: Devedjiev, Y.]]
	[[Category: Kang, B S.]]		[[Category: Kang, B S.]]
		+	[[Category: Adhesion-complex]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Nuclear protein]]
	[[Category: Pdz domain]]		[[Category: Pdz domain]]
-	[[Category: Signal transduction~~,nuclear protein~~]]	+	[[Category: Signal transduction]]
-		+
-	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:33:28 2009''~~	+