1oc7 - Revision history

OCA at 12:35, 13 December 2023

2023-12-13T12:35:00Z

←Older revision		Revision as of 12:35, 13 December 2023
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	<StructureSection load='1oc7' size='340' side='right'caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>		<StructureSection load='1oc7' size='340' side='right'caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_16454 Atcc 16454~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MA3~~:O1-~~METHYL-4-DEOXY-4-THIO-ALPHA~~-D-~~GLUCOSE~~'>~~MA3~~</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.11Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [https://pdbe.org/1oc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [https://pdbe.org/1oc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GUX6_HUMIN GUX6_HUMIN] Plays a central role in the recycling of plant biomass. The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the dissaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.<ref>PMID:9882628</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 16454~~]]	+	[[Category: Humicola insolens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boyer, V]]	+	[[Category: Boyer V]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Davies GJ]]
-	[[Category: Driguez, H]]	+	[[Category: Driguez H]]
-	[[Category: Frandsen~~, T P]]~~	+	[[Category: Frandsen TP]]
-	~~[[Category: Ossowski, I Von~~]]	+	[[Category: Schulein M]]
-	[[Category: Schulein, M]]	+	[[Category: Varrot A]]
-	[[Category: Varrot, A]]	+	[[Category: Von Ossowski I]]
-	[[Category: ~~Cellobiohydrolase]]~~	+
-	~~[[Category: Cellulase]]~~	+
-	~~[[Category: Cellulose degradation]]~~	+
-	~~[[Category: Glycoside hydrolase family 6]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Processive mechanism~~]]	+

OCA at 06:00, 28 April 2021

2021-04-28T06:00:41Z

←Older revision		Revision as of 06:00, 28 April 2021
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	<StructureSection load='1oc7' size='340' side='right'caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>		<StructureSection load='1oc7' size='340' side='right'caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~MA3~~:~~O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE~~'>~~MA3~~</scene>, <scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [~~http~~://pdbe.org/1oc7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oc7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [https://pdbe.org/1oc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [https://www.ebi.ac.uk/pdbsum/1oc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 06:54, 24 July 2019

2019-07-24T06:54:19Z

←Older revision		Revision as of 06:54, 24 July 2019
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	==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-tetrathio-alpha-d-cellopentoside at 1.1 angstrom resolution==		==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-tetrathio-alpha-d-cellopentoside at 1.1 angstrom resolution==
-	<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>	+	<StructureSection load='1oc7' size='340' side='right'caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1oc7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oc7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cellobiohydrolase 3D structures\|Cellobiohydrolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 16454]]		[[Category: Atcc 16454]]
		+	[[Category: Large Structures]]
	[[Category: Boyer, V]]		[[Category: Boyer, V]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 07:08, 7 February 2018

2018-02-07T07:08:19Z

←Older revision		Revision as of 07:08, 7 February 2018
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-	==D405N ~~MUTANT OF THE~~ CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS ~~IN COMPLEX WITH METHYL~~-~~TETRATHIO~~-~~ALPHA~~-D-~~CELLOPENTOSIDE AT~~ 1.1 ~~ANGSTROM RESOLUTION~~==	+
		+	==D405N mutant of the CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS in complex with methyl-tetrathio-alpha-d-cellopentoside at 1.1 angstrom resolution==
	<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>		<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://pdbe.org/1oc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://pdbe.org/1oc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 1oc7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oc7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cellobiohydrolase\|Cellobiohydrolase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 9 February 2016

2016-02-09T10:56:46Z

←Older revision		Revision as of 10:56, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oc7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:37, 10 September 2015

2015-09-10T21:37:21Z

←Older revision		Revision as of 21:37, 10 September 2015
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	<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>		<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Humicola_insolens Humicola insolens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16454 Atcc 16454]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-~~cellobiosidase~~ Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://pdbe.org/1oc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oc7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cellulose 1,4-beta-cellobiosidase]]~~	+	[[Category: Atcc 16454]]
-	~~[[Category: Humicola insolens~~]]	+
	[[Category: Boyer, V]]		[[Category: Boyer, V]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 16:31, 5 January 2015

2015-01-05T16:31:07Z

←Older revision		Revision as of 16:31, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Cellulose 1,4-beta-cellobiosidase]]		[[Category: Cellulose 1,4-beta-cellobiosidase]]
	[[Category: Humicola insolens]]		[[Category: Humicola insolens]]
-	[[Category: Boyer, V.]]	+	[[Category: Boyer, V]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Driguez, H.]]	+	[[Category: Driguez, H]]
-	[[Category: Frandsen, T P.]]	+	[[Category: Frandsen, T P]]
-	[[Category: Ossowski, I Von.]]	+	[[Category: Ossowski, I Von]]
-	[[Category: Schulein, M.]]	+	[[Category: Schulein, M]]
-	[[Category: Varrot, A.]]	+	[[Category: Varrot, A]]
	[[Category: Cellobiohydrolase]]		[[Category: Cellobiohydrolase]]
	[[Category: Cellulase]]		[[Category: Cellulase]]

OCA at 17:51, 28 September 2014

2014-09-28T17:51:19Z

←Older revision		Revision as of 17:51, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oc7.~~png~~\|~~left~~\|200px]]	+	==D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-TETRATHIO-ALPHA-D-CELLOPENTOSIDE AT 1.1 ANGSTROM RESOLUTION==
		+	<StructureSection load='1oc7' size='340' side='right' caption='[[1oc7]], [[Resolution\|resolution]] 1.11Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OC7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MA3:O1-METHYL-4-DEOXY-4-THIO-ALPHA-D-GLUCOSE'>MA3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGC:4-DEOXY-4-THIO-BETA-D-GLUCOPYRANOSE'>SGC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvw\|1bvw]], [[1gz1\|1gz1]], [[1hgw\|1hgw]], [[1hgy\|1hgy]], [[1oc5\|1oc5]], [[1oc6\|1oc6]], [[1ocb\|1ocb]], [[1ocj\|1ocj]], [[1ocn\|1ocn]], [[1qjw\|1qjw]], [[1qk0\|1qk0]], [[1qk2\|1qk2]], [[2bvw\|2bvw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase Cellulose 1,4-beta-cellobiosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oc7 RCSB], [http://www.ebi.ac.uk/pdbsum/1oc7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oc7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzymatic digestion of cellulose entails intimate involvement of cellobiohydrolases, whose characteristic active-center tunnel contributes to a processive degradation of the polysaccharide. The cellobiohydrolase Cel6A displays an active site within a tunnel formed by two extended loops, which are known to open and close in response to ligand binding. Here we present five structures of wild-type and mutant forms of Cel6A from Humicola insolens in complex with nonhydrolyzable thio-oligosaccharides, at resolutions from 1.7-1.1 A, dissecting the structural accommodation of a processing substrate chain through the active center during hydrolysis. Movement of ligand is facilitated by extensive solvent-mediated interactions and through flexibility in the hydrophobic surfaces provided by a sheath of tryptophan residues.

-	~~{{STRUCTURE_1oc7\| PDB=1oc7 \| SCENE= }}~~	+	Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens.,Varrot A, Frandsen TP, von Ossowski I, Boyer V, Cottaz S, Driguez H, Schulein M, Davies GJ Structure. 2003 Jul;11(7):855-64. PMID:12842048<ref>PMID:12842048</ref>

-	~~===D405N MUTANT OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH METHYL-TETRATHIO-ALPHA-D-CELLOPENTOSIDE AT 1.1 ANGSTROM RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12842048}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1oc7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Humicola_insolens Humicola insolens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA].~~	+

	==See Also==		==See Also==
	*[[Cellobiohydrolase\|Cellobiohydrolase]]		*[[Cellobiohydrolase\|Cellobiohydrolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012842048<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cellulose 1,4-beta-cellobiosidase]]		[[Category: Cellulose 1,4-beta-cellobiosidase]]
	[[Category: Humicola insolens]]		[[Category: Humicola insolens]]

OCA at 13:39, 20 October 2012

2012-10-20T13:39:09Z

←Older revision		Revision as of 13:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oc7]] is a 1 chain structure ~~of [[Cellobiohydrolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA].	+	[[1oc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Humicola_insolens Humicola insolens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OC7 OCA].

	==See Also==		==See Also==

OCA: Protected "1oc7" [edit=sysop:move=sysop]

2012-07-26T12:38:52Z

Protected "1oc7" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 26 July 2012