1oem - Revision history

OCA at 12:37, 13 December 2023

2023-12-13T12:37:33Z

←Older revision		Revision as of 12:37, 13 December 2023
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	<StructureSection load='1oem' size='340' side='right'caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oem' size='340' side='right'caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1a5y\|1a5y]]~~, [[~~1aax~~\|~~1aax~~]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</div></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.~~3.48 3.1.3.48] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [https://pdbe.org/1oem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [https://www.ebi.ac.uk/pdbsum/1oem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oem ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [https://pdbe.org/1oem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [https://www.ebi.ac.uk/pdbsum/1oem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oem ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>	+	[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Andersen JN]]
-	[[Category: Andersen~~, J N~~]]	+	[[Category: Barford D]]
-	[[Category: Barford, D]]	+	[[Category: Hinks JA]]
-	[[Category: Hinks~~, J A~~]]	+	[[Category: Meng TC]]
-	[[Category: Meng~~, T C~~]]	+	[[Category: Myers MP]]
-	[[Category: Myers~~, M P~~]]	+	[[Category: Salmeen A]]
-	[[Category: Salmeen, A]]	+	[[Category: Tonks NK]]
-	[[Category: Tonks~~, N K]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Phosphorylation~~]]	+

OCA at 09:57, 12 May 2021

2021-05-12T09:57:22Z

←Older revision		Revision as of 09:57, 12 May 2021
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	<StructureSection load='1oem' size='340' side='right'caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oem' size='340' side='right'caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OEM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [~~http~~://pdbe.org/1oem PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oem PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oem ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [https://pdbe.org/1oem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [https://www.ebi.ac.uk/pdbsum/1oem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oem ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>	+	[[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:42, 7 August 2019

2019-08-07T06:42:13Z

←Older revision		Revision as of 06:42, 7 August 2019
Line 1:		Line 1:

	==PTP1B with the catalytic cysteine oxidized to a sulfenyl-amide bond==		==PTP1B with the catalytic cysteine oxidized to a sulfenyl-amide bond==
-	<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1oem' size='340' side='right'caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oem_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oem_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1oem" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oem" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Andersen, J N]]		[[Category: Andersen, J N]]

OCA at 09:52, 1 November 2017

2017-11-01T09:52:10Z

←Older revision		Revision as of 09:52, 1 November 2017
Line 1:		Line 1:
-	==PTP1B ~~WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL~~-~~AMIDE BOND~~==	+
		+	==PTP1B with the catalytic cysteine oxidized to a sulfenyl-amide bond==
	<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://pdbe.org/1oem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://pdbe.org/1oem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oem ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oem ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1oem" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oem" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:17, 11 September 2015

2015-09-11T08:17:25Z

←Older revision		Revision as of 08:17, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://pdbe.org/1oem PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oem" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Andersen, J N]]		[[Category: Andersen, J N]]

OCA at 13:45, 25 December 2014

2014-12-25T13:45:03Z

←Older revision		Revision as of 13:45, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Andersen, J N.]]	+	[[Category: Andersen, J N]]
-	[[Category: Barford, D.]]	+	[[Category: Barford, D]]
-	[[Category: Hinks, J A.]]	+	[[Category: Hinks, J A]]
-	[[Category: Meng, T C.]]	+	[[Category: Meng, T C]]
-	[[Category: Myers, M P.]]	+	[[Category: Myers, M P]]
-	[[Category: Salmeen, A.]]	+	[[Category: Salmeen, A]]
-	[[Category: Tonks, N K.]]	+	[[Category: Tonks, N K]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Phosphatase]]		[[Category: Phosphatase]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]

OCA at 15:56, 28 September 2014

2014-09-28T15:56:20Z

←Older revision		Revision as of 15:56, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oem.~~png~~\|~~left~~\|200px]]	+	==PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND==
		+	<StructureSection load='1oem' size='340' side='right' caption='[[1oem]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a5y\|1a5y]], [[1aax\|1aax]], [[1bzc\|1bzc]], [[1bzh\|1bzh]], [[1bzj\|1bzj]], [[1c83\|1c83]], [[1c84\|1c84]], [[1c85\|1c85]], [[1c86\|1c86]], [[1c87\|1c87]], [[1c88\|1c88]], [[1ecv\|1ecv]], [[1een\|1een]], [[1eeo\|1eeo]], [[1g1f\|1g1f]], [[1g1g\|1g1g]], [[1g1h\|1g1h]], [[1g7f\|1g7f]], [[1g7g\|1g7g]], [[1gfy\|1gfy]], [[1i57\|1i57]], [[1jf7\|1jf7]], [[1kak\|1kak]], [[1kav\|1kav]], [[1l8g\|1l8g]], [[1lqf\|1lqf]], [[1n6w\|1n6w]], [[1nl9\|1nl9]], [[1nny\|1nny]], [[1no6\|1no6]], [[1nwl\|1nwl]], [[1oeo\|1oeo]], [[1oes\|1oes]], [[1oet\|1oet]], [[1oeu\|1oeu]], [[1oev\|1oev]], [[1ptt\|1ptt]], [[1ptu\|1ptu]], [[1ptv\|1ptv]], [[1pty\|1pty]], [[2hnp\|2hnp]], [[2hnq\|2hnq]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oem RCSB], [http://www.ebi.ac.uk/pdbsum/1oem PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oem_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The second messenger hydrogen peroxide is required for optimal activation of numerous signal transduction pathways, particularly those mediated by protein tyrosine kinases. One mechanism by which hydrogen peroxide regulates cellular processes is the transient inhibition of protein tyrosine phosphatases through the reversible oxidization of their catalytic cysteine, which suppresses protein dephosphorylation. Here we describe a structural analysis of the redox-dependent regulation of protein tyrosine phosphatase 1B (PTP1B), which is reversibly inhibited by oxidation after cells are stimulated with insulin and epidermal growth factor. The sulphenic acid intermediate produced in response to PTP1B oxidation is rapidly converted into a previously unknown sulphenyl-amide species, in which the sulphur atom of the catalytic cysteine is covalently linked to the main chain nitrogen of an adjacent residue. Oxidation of PTP1B to the sulphenyl-amide form is accompanied by large conformational changes in the catalytic site that inhibit substrate binding. We propose that this unusual protein modification both protects the active-site cysteine residue of PTP1B from irreversible oxidation to sulphonic acid and permits redox regulation of the enzyme by promoting its reversible reduction by thiols.

-	~~{{STRUCTURE_1oem\| PDB=1oem \| SCENE= }}~~	+	Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate.,Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK, Barford D Nature. 2003 Jun 12;423(6941):769-73. PMID:12802338<ref>PMID:12802338</ref>

-	~~===PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12802338}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1oem]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA].~~	+

	==See Also==		==See Also==
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:012802338<~~/~~ref~~><~~ref group="xtra">PMID:015258570</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]

OCA at 17:24, 20 October 2012

2012-10-20T17:24:25Z

←Older revision		Revision as of 17:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oem]] is a 1 chain structure ~~of [[Tyrosine phosphatase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA].	+	[[1oem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA].

	==See Also==		==See Also==

OCA at 11:32, 14 August 2012

2012-08-14T11:32:31Z

←Older revision		Revision as of 11:32, 14 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oem]] is a 1 chain structure of ~~[[Proten tyrosine phosphatase]] and~~ [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA].	+	[[1oem]] is a 1 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEM OCA].

	==See Also==		==See Also==
-	*[[Proten tyrosine phosphatase\|Proten tyrosine phosphatase]]
	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]		*[[Tyrosine phosphatase\|Tyrosine phosphatase]]

OCA: Protected "1oem" [edit=sysop:move=sysop]

2012-07-27T00:47:27Z

Protected "1oem" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:47, 27 July 2012