1on2 - Revision history

OCA at 08:01, 14 February 2024

2024-02-14T08:01:51Z

←Older revision		Revision as of 08:01, 14 February 2024
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	<StructureSection load='1on2' size='340' side='right'caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='1on2' size='340' side='right'caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.61Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1on1\|1on1]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [https://pdbe.org/1on2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [https://www.ebi.ac.uk/pdbsum/1on2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1on2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [https://pdbe.org/1on2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [https://www.ebi.ac.uk/pdbsum/1on2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1on2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.	+	[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1on2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1on2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The Bacillus subtilis manganese transport regulator, MntR, binds Mn2+ as an effector and is a repressor of transporters that import manganese. A member of the diphtheria toxin repressor (DtxR) family of metalloregulatory proteins, MntR exhibits selectivity for Mn2+ over Fe2+. Replacement of a metal-binding residue, Asp8, with methionine (D8M) relaxes this specificity. We report here the X-ray crystal structures of wild-type MntR and the D8M mutant bound to manganese with 1.75 A and 1.61 A resolution, respectively. The 142-residue MntR homodimer has substantial structural similarity to the 226-residue DtxR but lacks the C-terminal SH3-like domain of DtxR. The metal-binding pockets of MntR and DtxR are substantially different. The cation-to-cation distance between the two manganese ions bound by MntR is 3.3 A, whereas that between the metal ions bound by DtxR is 9 A. D8M binds only a single Mn2+ per monomer, owing to alteration of the metal-binding site. The sole retained metal site adopts pseudo-hexacoordinate geometry rather than the pseudo-heptacoordinate geometry of the MntR metal sites.
-
-	Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.,Glasfeld A, Guedon E, Helmann JD, Brennan RG Nat Struct Biol. 2003 Aug;10(8):652-7. PMID:12847518<ref>PMID:12847518</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1on2" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brennan~~, R G~~]]	+	[[Category: Brennan RG]]
-	[[Category: Glasfeld, A]]	+	[[Category: Glasfeld A]]
-	[[Category: Guedon, E]]	+	[[Category: Guedon E]]
-	[[Category: Helmann~~, J D]]~~	+	[[Category: Helmann JD]]
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Metalloregulatory protein]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 09:18, 8 September 2021

2021-09-08T09:18:33Z

←Older revision		Revision as of 09:18, 8 September 2021
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	<StructureSection load='1on2' size='340' side='right'caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='1on2' size='340' side='right'caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1on1\|1on1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [~~http~~://pdbe.org/1on2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1on2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1on2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [https://pdbe.org/1on2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [https://www.ebi.ac.uk/pdbsum/1on2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1on2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.	+	[[https://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:45, 20 November 2019

2019-11-20T18:45:02Z

←Older revision		Revision as of 18:45, 20 November 2019
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	==Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese==		==Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese==
-	<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>	+	<StructureSection load='1on2' size='340' side='right'caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 07:54, 15 February 2018

2018-02-15T07:54:31Z

←Older revision		Revision as of 07:54, 15 February 2018
Line 1:		Line 1:
		+
	==Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese==		==Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese==
	<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://pdbe.org/1on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://pdbe.org/1on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1on2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1on2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1on2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 15:38, 7 February 2016

2016-02-07T15:38:10Z

←Older revision		Revision as of 15:38, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1on2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:51, 10 September 2015

2015-09-10T02:51:41Z

←Older revision		Revision as of 02:51, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://pdbe.org/1on2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1on2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Glasfeld, A]]		[[Category: Glasfeld, A]]

OCA at 16:21, 24 December 2014

2014-12-24T16:21:56Z

←Older revision		Revision as of 16:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MNTR_BACSU MNTR_BACSU]] Central regulator of manganese homeostasis. In the presence of manganese, it mediates repression of the manganese transporter MntH; under low manganese conditions, it activates the transcription of the mntABCD operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Brennan, R G.]]	+	[[Category: Brennan, R G]]
-	[[Category: Glasfeld, A.]]	+	[[Category: Glasfeld, A]]
-	[[Category: Guedon, E.]]	+	[[Category: Guedon, E]]
-	[[Category: Helmann, J D.]]	+	[[Category: Helmann, J D]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 17:21, 28 September 2014

2014-09-28T17:21:34Z

←Older revision		Revision as of 17:21, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1on2.~~png~~\|~~left~~\|200px]]	+	==Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese==
		+	<StructureSection load='1on2' size='340' side='right' caption='[[1on2]], [[Resolution\|resolution]] 1.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ON2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1on1\|1on1]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1on2 RCSB], [http://www.ebi.ac.uk/pdbsum/1on2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1on2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Bacillus subtilis manganese transport regulator, MntR, binds Mn2+ as an effector and is a repressor of transporters that import manganese. A member of the diphtheria toxin repressor (DtxR) family of metalloregulatory proteins, MntR exhibits selectivity for Mn2+ over Fe2+. Replacement of a metal-binding residue, Asp8, with methionine (D8M) relaxes this specificity. We report here the X-ray crystal structures of wild-type MntR and the D8M mutant bound to manganese with 1.75 A and 1.61 A resolution, respectively. The 142-residue MntR homodimer has substantial structural similarity to the 226-residue DtxR but lacks the C-terminal SH3-like domain of DtxR. The metal-binding pockets of MntR and DtxR are substantially different. The cation-to-cation distance between the two manganese ions bound by MntR is 3.3 A, whereas that between the metal ions bound by DtxR is 9 A. D8M binds only a single Mn2+ per monomer, owing to alteration of the metal-binding site. The sole retained metal site adopts pseudo-hexacoordinate geometry rather than the pseudo-heptacoordinate geometry of the MntR metal sites.

-	~~{{STRUCTURE_1on2\| PDB=1on2 \| SCENE= }}~~	+	Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.,Glasfeld A, Guedon E, Helmann JD, Brennan RG Nat Struct Biol. 2003 Aug;10(8):652-7. PMID:12847518<ref>PMID:12847518</ref>

-	~~===Bacillus subtilis Manganese Transport Regulator (MntR)~~, ~~D8M Mutant, Bound to Manganese===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_12847518}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1on2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:012847518<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA: Protected "1on2" [edit=sysop:move=sysop]

2012-12-12T21:58:24Z

Protected "1on2" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:58, 12 December 2012

OCA at 21:58, 12 December 2012

2012-12-12T21:58:21Z

←Older revision		Revision as of 21:58, 12 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1on2.png\|left\|200px]]		[[Image:1on2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1on2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1on2\| PDB=1on2 \| SCENE= }}		{{STRUCTURE_1on2\| PDB=1on2 \| SCENE= }}

	===Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese===		===Bacillus subtilis Manganese Transport Regulator (MntR), D8M Mutant, Bound to Manganese===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_12847518}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 12847518 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_12847518}}		{{ABSTRACT_PUBMED_12847518}}

	==About this Structure==		==About this Structure==
-	~~1ON2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA].	+	[[1on2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~12847518~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:012847518</ref><references group="xtra"/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]
Line 32:		Line 20:
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
	[[Category: Metalloregulatory protein]]		[[Category: Metalloregulatory protein]]
-		+	[[Category: Transcription]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Mon Feb 16 14:49:49 2009''~~	+