1oz6 - Revision history

OCA at 07:21, 25 October 2023

2023-10-25T07:21:54Z

←Older revision		Revision as of 07:21, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1cl5\|1cl5]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [https://pdbe.org/1oz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [https://pdbe.org/1oz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PA2A1_ECHCA PA2A1_ECHCA]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>	+	[https://www.uniprot.org/uniprot/PA2A1_ECHCA PA2A1_ECHCA] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 38:
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jasti, J]]	+	[[Category: Jasti J]]
-	[[Category: Paramasivam, M]]	+	[[Category: Paramasivam M]]
-	[[Category: Singh~~, T P~~]]	+	[[Category: Singh TP]]
-	[[Category: Srinivasan, A]]	+	[[Category: Srinivasan A]]
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pla2~~]]	+

OCA at 09:22, 8 September 2021

2021-09-08T09:22:58Z

←Older revision		Revision as of 09:22, 8 September 2021
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	<StructureSection load='1oz6' size='340' side='right'caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1oz6' size='340' side='right'caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cl5\|1cl5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [~~http~~://pdbe.org/1oz6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1oz6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [https://pdbe.org/1oz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PA2A1_ECHCA PA2A1_ECHCA]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>	+	[[https://www.uniprot.org/uniprot/PA2A1_ECHCA PA2A1_ECHCA]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:19, 27 November 2019

2019-11-27T10:19:08Z

←Older revision		Revision as of 10:19, 27 November 2019
Line 1:		Line 1:

	==X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity==		==X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity==
-	<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1oz6' size='340' side='right'caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1oz6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oz6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
		+	[[Category: Large Structures]]
	[[Category: Jasti, J]]		[[Category: Jasti, J]]
	[[Category: Paramasivam, M]]		[[Category: Paramasivam, M]]

OCA at 07:48, 15 February 2018

2018-02-15T07:48:57Z

←Older revision		Revision as of 07:48, 15 February 2018
Line 1:		Line 1:
		+
	==X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity==		==X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity==
	<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Echca Echca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://pdbe.org/1oz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://pdbe.org/1oz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1oz6_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1oz6_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1oz6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1oz6" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Echca~~]]	+	[[Category: Echis carinatus]]
	[[Category: Jasti, J]]		[[Category: Jasti, J]]
	[[Category: Paramasivam, M]]		[[Category: Paramasivam, M]]

OCA at 20:53, 9 February 2016

2016-02-09T20:53:56Z

←Older revision		Revision as of 20:53, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oz6 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:56, 11 September 2015

2015-09-11T01:56:31Z

←Older revision		Revision as of 01:56, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Echis_carinatus Echis carinatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echca Echca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://pdbe.org/1oz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q7T3S7_ECHCA Q7T3S7_ECHCA~~]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>	+	[[http://www.uniprot.org/uniprot/PA2A1_ECHCA PA2A1_ECHCA]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1oz6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Echis carinatus~~]]	+	[[Category: Echca]]
	[[Category: Jasti, J]]		[[Category: Jasti, J]]
	[[Category: Paramasivam, M]]		[[Category: Paramasivam, M]]

OCA at 09:27, 25 December 2014

2014-12-25T09:27:58Z

←Older revision		Revision as of 09:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7T3S7_ECHCA Q7T3S7_ECHCA]] Snake venom phospholipase A2 (PLA2) that inhibits human platelet aggregation induced by ADP, collagen and epinephrin (possibly by binding the platelet receptor alpha-IIb/beta-III) and induces mild edema in the foot pads of mice. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:10519645</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
-	[[Category: Jasti, J.]]	+	[[Category: Jasti, J]]
-	[[Category: Paramasivam, M.]]	+	[[Category: Paramasivam, M]]
-	[[Category: Singh, T P.]]	+	[[Category: Singh, T P]]
-	[[Category: Srinivasan, A.]]	+	[[Category: Srinivasan, A]]
	[[Category: Enzyme]]		[[Category: Enzyme]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pla2]]		[[Category: Pla2]]

OCA at 22:29, 28 September 2014

2014-09-28T22:29:13Z

←Older revision		Revision as of 22:29, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1oz6.~~png~~\|~~left~~\|200px]]	+	==X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity==
		+	<StructureSection load='1oz6' size='340' side='right' caption='[[1oz6]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OZ6 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cl5\|1cl5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oz6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1oz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1oz6 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/1oz6_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of an acidic phospholipase A(2) from the venom of Echis carinatus (saw-scaled viper; scPLA(2)) has been determined at 2.6 A resolution and refined to a crystallographic R factor of 0.192. Although the overall structure of scPLA(2) is essentially similar to those of other group II acidic PLA(2)s from different species, it shows unique features in several parts. Particularly noteworthy is the C-terminal part, which folds differently to those of other group II PLA(2)s. This part is considered to be responsible for inhibition of the platelet-aggregation activity. The calcium-binding loop is tightly organized with sevenfold coordination. Another striking feature of scPLA(2) is the involvement of Asn79 O(delta1) of a symmetry-related molecule in a coordination linkage with Ca(2+) of the calcium-binding loop. This is the first observation of an internal metal ion participating in an intermolecular interaction. The beta-wing of a molecule is deeply inserted into the hydrophobic channel of another molecule and forms several intermolecular interactions. This results in the formation of an infinite chain of molecules. These chains are stacked in an antiparallel arrangement in the crystals.

-	~~{{STRUCTURE_1oz6\| PDB=1oz6 \| SCENE= }}~~	+	Structure of an acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) at 2.6 A resolution reveals a novel intermolecular interaction.,Jasti J, Paramasivam M, Srinivasan A, Singh TP Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):66-72. Epub 2003, Dec 18. PMID:14684894<ref>PMID:14684894</ref>

-	~~===X-ray structure~~ of ~~acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14684894}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1oz6]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Echis_carinatus Echis carinatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014684894<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
	[[Category: Jasti, J.]]		[[Category: Jasti, J.]]

OCA at 15:06, 20 October 2012

2012-10-20T15:06:36Z

←Older revision		Revision as of 15:06, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1oz6]] is a 1 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA].	+	[[1oz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echis_carinatus Echis carinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ6 OCA].

	==See Also==		==See Also==

OCA at 17:19, 26 July 2012

2012-07-26T17:19:10Z

←Older revision		Revision as of 17:19, 26 July 2012
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	[[Image:1oz6.png\|left\|200px]]		[[Image:1oz6.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1oz6", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1oz6\| PDB=1oz6 \| SCENE= }}		{{STRUCTURE_1oz6\| PDB=1oz6 \| SCENE= }}

	===X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity===		===X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_14684894}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 14684894 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_14684894}}		{{ABSTRACT_PUBMED_14684894}}

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	==See Also==		==See Also==
-	*[[Phospholipase A2]]	+	*[[Phospholipase A2\|Phospholipase A2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~14684894~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:014684894</ref><references group="xtra"/>
	[[Category: Echis carinatus]]		[[Category: Echis carinatus]]
	[[Category: Jasti, J.]]		[[Category: Jasti, J.]]