1paf - Revision history

OCA at 05:54, 17 April 2024

2024-04-17T05:54:01Z

←Older revision		Revision as of 05:54, 17 April 2024
Line 3:		Line 3:
	<StructureSection load='1paf' size='340' side='right'caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1paf' size='340' side='right'caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~American_pokeweed American pokeweed~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PAF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [https://pdbe.org/1paf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [https://www.ebi.ac.uk/pdbsum/1paf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1paf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [https://pdbe.org/1paf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [https://www.ebi.ac.uk/pdbsum/1paf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1paf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RIP1_PHYAM RIP1_PHYAM]] Inhibits viral infection of plants, and protein synthesis in vitro.	+	[https://www.uniprot.org/uniprot/RIP1_PHYAM RIP1_PHYAM] Inhibits viral infection of plants, and protein synthesis in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1paf ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1paf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional structure of PAP determined to 2.5 A resolution by X-ray crystallography. After 14 rounds of refinement, the R factor is 0.17 for 5.0 to 2.5 A data. The protein is homologous with the A chain of ricin and exhibits a very similar folding pattern. The positions of key active site residues are also similar. We also report the 2.8 A structure of PAP complexed with a substrate analog, formycin 5'-monophosphate. As seen previously in ricin, the formycin ring is stacked between invariant tyrosines 72 and 123. Arg179 bonds to N-3 which is thought to be important in catalysis.
-
-	The 2.5 A structure of pokeweed antiviral protein.,Monzingo AF, Collins EJ, Ernst SR, Irvin JD, Robertus JD J Mol Biol. 1993 Oct 20;233(4):705-15. PMID:8411176<ref>PMID:8411176</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Ribosome inactivating protein\|Ribosome inactivating protein]]	+	*[[Ribosome inactivating protein 3D structures\|Ribosome inactivating protein 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: American pokeweed]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Collins, E J~~]]	+	[[Category: Phytolacca americana]]
-	[[Category: ~~Ernst, S R~~]]	+	[[Category: Collins EJ]]
-	[[Category: ~~Irvin, J D~~]]	+	[[Category: Ernst SR]]
-	[[Category: ~~Monzingo, A F~~]]	+	[[Category: Irvin JD]]
-	[[Category: ~~Robertus, J D~~]]	+	[[Category: Monzingo AF]]
-	[[Category: ~~Protein synthesis inhibitor~~]]	+	[[Category: Robertus JD]]

OCA at 09:26, 8 September 2021

2021-09-08T09:26:58Z

←Older revision		Revision as of 09:26, 8 September 2021
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	<StructureSection load='1paf' size='340' side='right'caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1paf' size='340' side='right'caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PAF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [~~http~~://pdbe.org/1paf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1paf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1paf ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [https://pdbe.org/1paf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [https://www.ebi.ac.uk/pdbsum/1paf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1paf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RIP1_PHYAM RIP1_PHYAM]] Inhibits viral infection of plants, and protein synthesis in vitro.	+	[[https://www.uniprot.org/uniprot/RIP1_PHYAM RIP1_PHYAM]] Inhibits viral infection of plants, and protein synthesis in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:29, 27 November 2019

2019-11-27T10:29:29Z

←Older revision		Revision as of 10:29, 27 November 2019
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	==THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN==		==THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN==
-	<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1paf' size='340' side='right'caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>		<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome inactivating protein\|Ribosome inactivating protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: American pokeweed]]		[[Category: American pokeweed]]
		+	[[Category: Large Structures]]
	[[Category: Collins, E J]]		[[Category: Collins, E J]]
	[[Category: Ernst, S R]]		[[Category: Ernst, S R]]

OCA at 07:57, 15 February 2018

2018-02-15T07:57:16Z

←Older revision		Revision as of 07:57, 15 February 2018
Line 1:		Line 1:
		+
	==THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN==		==THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN==
	<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>		<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://pdbe.org/1paf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://pdbe.org/1paf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1paf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1paf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1paf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 26:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ribosome inactivating protein\|Ribosome inactivating protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:32, 10 February 2016

2016-02-10T00:32:27Z

←Older revision		Revision as of 00:32, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1paf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 03:35, 11 September 2015

2015-09-11T03:35:33Z

←Older revision		Revision as of 03:35, 11 September 2015
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	<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Phytolacca_americana Phytolacca americana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/American_pokeweed American pokeweed]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://pdbe.org/1paf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1paf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome inactivating protein\|Ribosome inactivating protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Phytolacca americana~~]]	+	[[Category: American pokeweed]]
	[[Category: Collins, E J]]		[[Category: Collins, E J]]
	[[Category: Ernst, S R]]		[[Category: Ernst, S R]]

OCA at 10:32, 25 December 2014

2014-12-25T10:32:49Z

←Older revision		Revision as of 10:32, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>		<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RIP1_PHYAM RIP1_PHYAM]] Inhibits viral infection of plants, and protein synthesis in vitro.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Phytolacca americana]]		[[Category: Phytolacca americana]]
-	[[Category: Collins, E J.]]	+	[[Category: Collins, E J]]
-	[[Category: Ernst, S R.]]	+	[[Category: Ernst, S R]]
-	[[Category: Irvin, J D.]]	+	[[Category: Irvin, J D]]
-	[[Category: Monzingo, A F.]]	+	[[Category: Monzingo, A F]]
-	[[Category: Robertus, J D.]]	+	[[Category: Robertus, J D]]
	[[Category: Protein synthesis inhibitor]]		[[Category: Protein synthesis inhibitor]]

OCA at 23:36, 28 September 2014

2014-09-28T23:36:25Z

←Older revision		Revision as of 23:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1paf.~~png\|left~~\|200px]]	+	==THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN==
		+	<StructureSection load='1paf' size='340' side='right' caption='[[1paf]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PAF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1paf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1paf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1paf RCSB], [http://www.ebi.ac.uk/pdbsum/1paf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1paf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional structure of PAP determined to 2.5 A resolution by X-ray crystallography. After 14 rounds of refinement, the R factor is 0.17 for 5.0 to 2.5 A data. The protein is homologous with the A chain of ricin and exhibits a very similar folding pattern. The positions of key active site residues are also similar. We also report the 2.8 A structure of PAP complexed with a substrate analog, formycin 5'-monophosphate. As seen previously in ricin, the formycin ring is stacked between invariant tyrosines 72 and 123. Arg179 bonds to N-3 which is thought to be important in catalysis.

-	~~{{STRUCTURE_1paf\| PDB=1paf \| SCENE= }}~~	+	The 2.5 A structure of pokeweed antiviral protein.,Monzingo AF, Collins EJ, Ernst SR, Irvin JD, Robertus JD J Mol Biol. 1993 Oct 20;233(4):705-15. PMID:8411176<ref>PMID:8411176</ref>

-	~~===THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8411176}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1paf]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Phytolacca_americana Phytolacca americana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008411176<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Phytolacca americana]]		[[Category: Phytolacca americana]]
	[[Category: Collins, E J.]]		[[Category: Collins, E J.]]

OCA: Protected "1paf" [edit=sysop:move=sysop]

2012-12-19T12:05:39Z

Protected "1paf" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:05, 19 December 2012

OCA at 12:05, 19 December 2012

2012-12-19T12:05:37Z

←Older revision		Revision as of 12:05, 19 December 2012
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	[[Image:1paf.png\|left\|200px]]		[[Image:1paf.png\|left\|200px]]

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	{{STRUCTURE_1paf\| PDB=1paf \| SCENE= }}		{{STRUCTURE_1paf\| PDB=1paf \| SCENE= }}

	===THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN===		===THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN===

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	==About this Structure==		==About this Structure==
-	~~1PAF~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA].	+	[[1paf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Phytolacca_americana Phytolacca americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PAF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8411176~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008411176</ref><references group="xtra"/>
	[[Category: Phytolacca americana]]		[[Category: Phytolacca americana]]
	[[Category: Collins, E J.]]		[[Category: Collins, E J.]]
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	[[Category: Robertus, J D.]]		[[Category: Robertus, J D.]]
	[[Category: Protein synthesis inhibitor]]		[[Category: Protein synthesis inhibitor]]
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