1piq - Revision history

OCA at 07:11, 9 August 2023

2023-08-09T07:11:37Z

←Older revision		Revision as of 07:11, 9 August 2023
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	<StructureSection load='1piq' size='340' side='right'caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1piq' size='340' side='right'caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [https://pdbe.org/1piq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [https://www.ebi.ac.uk/pdbsum/1piq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1piq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [https://pdbe.org/1piq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [https://www.ebi.ac.uk/pdbsum/1piq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1piq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Eckert, D M~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Kim, P S~~]]	+	[[Category: Eckert DM]]
-	[[Category: ~~Malashkevich, V N~~]]	+	[[Category: Kim PS]]
-	[[Category: ~~Buried polar residue]]~~	+	[[Category: Malashkevich VN]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Ion binding~~]]	+

OCA at 09:30, 8 September 2021

2021-09-08T09:30:23Z

←Older revision		Revision as of 09:30, 8 September 2021
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	<StructureSection load='1piq' size='340' side='right'caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1piq' size='340' side='right'caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [~~http~~://pdbe.org/1piq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1piq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1piq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [https://pdbe.org/1piq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [https://www.ebi.ac.uk/pdbsum/1piq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1piq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:18, 27 November 2019

2019-11-27T10:18:41Z

←Older revision		Revision as of 10:18, 27 November 2019
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	==CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES==		==CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES==
-	<StructureSection load='1piq' size='340' side='right' caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1piq' size='340' side='right'caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 1piq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1piq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eckert, D M]]		[[Category: Eckert, D M]]
	[[Category: Kim, P S]]		[[Category: Kim, P S]]

OCA at 07:48, 15 February 2018

2018-02-15T07:48:17Z

←Older revision		Revision as of 07:48, 15 February 2018
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES==		==CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES==
	<StructureSection load='1piq' size='340' side='right' caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1piq' size='340' side='right' caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://pdbe.org/1piq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://pdbe.org/1piq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1piq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 1piq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1piq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:01, 10 September 2015

2015-09-10T18:01:08Z

←Older revision		Revision as of 18:01, 10 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://pdbe.org/1piq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1piq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 03:59, 25 December 2014

2014-12-25T03:59:20Z

←Older revision		Revision as of 03:59, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Eckert, D M.]]	+	[[Category: Eckert, D M]]
-	[[Category: Kim, P S.]]	+	[[Category: Kim, P S]]
-	[[Category: Malashkevich, V N.]]	+	[[Category: Malashkevich, V N]]
	[[Category: Buried polar residue]]		[[Category: Buried polar residue]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Ion binding]]		[[Category: Ion binding]]

OCA at 21:12, 28 September 2014

2014-09-28T21:12:43Z

←Older revision		Revision as of 21:12, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1piq.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES==
		+	<StructureSection load='1piq' size='340' side='right' caption='[[1piq]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PIQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1piq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1piq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1piq RCSB], [http://www.ebi.ac.uk/pdbsum/1piq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Coiled coils consist of two or more alpha-helices wrapped around each other with a superhelical twist. The interfaces between helices of a coiled coil are formed by hydrophobic amino acid residues packed in a "knobs-into-holes" arrangement. Most naturally occurring coiled coils, however, also contain buried polar residues, as do the cores of the majority of naturally occurring globular proteins. Two common buried polar residues in both dimeric and trimeric coiled coils are asparagine and glutamine. In dimeric coiled coils, buried asparagine, but not glutamine, residues have been shown to confer specificity of oligomerization. We have placed a glutamine residue in the otherwise hydrophobic interior of a stable trimeric coiled coil, GCN4-pII, to study the effect of this buried polar residue in a trimeric coiled-coil environment. The resulting peptide, GCN4-pIQI, is a discrete, trimeric coiled coil with a lower stability than GCN4-pII. The crystal structure determined to 1.8 A shows that GCN4-pIQI is a trimeric coiled coil with a chloride ion coordinated by one buried glutamine residue from each monomer.

-	~~{{STRUCTURE_1piq\| PDB=1piq \| SCENE= }}~~	+	Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues.,Eckert DM, Malashkevich VN, Kim PS J Mol Biol. 1998 Dec 11;284(4):859-65. PMID:9837709<ref>PMID:9837709</ref>

-	~~===CRYSTAL STRUCTURE OF GCN4-PIQ~~, ~~A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_9837709}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1piq~~]] ~~is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:015048824<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Eckert, D M.]]		[[Category: Eckert, D M.]]
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]

OCA: Protected "1piq" [edit=sysop:move=sysop]

2012-12-19T11:53:31Z

Protected "1piq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 19 December 2012

OCA at 11:53, 19 December 2012

2012-12-19T11:53:28Z

←Older revision		Revision as of 11:53, 19 December 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1piq.png\|left\|200px]]		[[Image:1piq.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1piq\| PDB=1piq \| SCENE= }}		{{STRUCTURE_1piq\| PDB=1piq \| SCENE= }}

	===CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES===		===CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES===

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	{{ABSTRACT_PUBMED_9837709}}		{{ABSTRACT_PUBMED_9837709}}

	==About this Structure==		==About this Structure==
-	~~1PIQ is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA].	+	[[1piq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIQ OCA].

	==Reference==		==Reference==
-	~~Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues., Eckert DM, Malashkevich VN, Kim PS, J Mol Biol. 1998 Dec 11;284(4):859-65.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9837709 9837709]~~	+	<ref group="xtra">PMID:015048824</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Eckert, D M.]]		[[Category: Eckert, D M.]]
	[[Category: Kim, P S.]]		[[Category: Kim, P S.]]
	[[Category: Malashkevich, V N.]]		[[Category: Malashkevich, V N.]]
	[[Category: Buried polar residue]]		[[Category: Buried polar residue]]
-	[[Category: ~~Coiled coil~~]]	+	[[Category: Dna binding protein]]
	[[Category: Ion binding]]		[[Category: Ion binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:26:26 2008''

OCA at 06:26, 28 July 2008

2008-07-28T06:26:30Z

←Older revision		Revision as of 06:26, 28 July 2008
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-	[[Image:1piq.~~gif~~\|left\|200px]]	+	{{Seed}}
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	{{STRUCTURE_1piq\| PDB=1piq \| SCENE= }}		{{STRUCTURE_1piq\| PDB=1piq \| SCENE= }}

-	~~'''~~CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES~~'''~~	+	===CRYSTAL STRUCTURE OF GCN4-PIQ, A TRIMERIC COILED COIL WITH BURIED POLAR RESIDUES===


-	~~==Overview==~~	+	<!--
-	~~Coiled coils consist of two or more alpha-helices wrapped around each other with a superhelical twist.~~ The ~~interfaces between helices of a coiled coil are formed by hydrophobic amino acid residues packed in a "knobs-into-holes" arrangement. Most naturally occurring coiled coils~~, ~~however~~, ~~also contain buried polar residues, as do~~ the ~~cores of~~ the ~~majority of naturally occurring globular proteins~~. ~~Two common buried polar residues in both dimeric and trimeric coiled coils are asparagine and glutamine~~. ~~In dimeric coiled coils~~, ~~buried asparagine, but not glutamine, residues have been shown to confer specificity of oligomerization. We have placed a glutamine residue in~~ the ~~otherwise hydrophobic interior of a stable trimeric coiled coil, GCN4-pII, to study the effect of this buried polar residue in a trimeric coiled-coil environment~~. ~~The resulting peptide, GCN4~~-~~pIQI, is a discrete, trimeric coiled coil with a lower stability than GCN4~~-~~pII. The crystal structure determined to 1.8 A shows that GCN4-pIQI is a trimeric coiled coil with a chloride ion coordinated by one buried glutamine residue from each monomer.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9837709}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9837709 is the PubMed ID number.
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		+	{{ABSTRACT_PUBMED_9837709}}

	==About this Structure==		==About this Structure==
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	[[Category: Coiled coil]]		[[Category: Coiled coil]]
	[[Category: Ion binding]]		[[Category: Ion binding]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:07:39 2008''	+
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