1pn4 - Revision history

OCA at 09:45, 16 August 2023

2023-08-16T09:45:37Z

←Older revision		Revision as of 09:45, 16 August 2023
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	<StructureSection load='1pn4' size='340' side='right'caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1pn4' size='340' side='right'caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_4563 Atcc 4563~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1pn2\|1pn2]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FOX2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [https://pdbe.org/1pn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1pn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [https://pdbe.org/1pn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1pn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR]] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.	+	[https://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 4563~~]]	+	[[Category: Candida tropicalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Glumoff, T]]	+	[[Category: Glumoff T]]
-	[[Category: Haapalainen~~, A M~~]]	+	[[Category: Haapalainen AM]]
-	[[Category: Hiltunen~~, J K~~]]	+	[[Category: Hiltunen JK]]
-	[[Category: Koski~~, M K]]~~	+	[[Category: Koski MK]]
-	~~[[Category: Enzyme-product complex]]~~	+
-	~~[[Category: Hot-dog fold]]~~	+
-	~~[[Category: Hydratase 2 motif]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Oxyanion hole~~]]	+

OCA at 06:01, 28 April 2021

2021-04-28T06:01:59Z

←Older revision		Revision as of 06:01, 28 April 2021
Line 3:		Line 3:
	<StructureSection load='1pn4' size='340' side='right'caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1pn4' size='340' side='right'caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_4563 Atcc 4563]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_4563 Atcc 4563]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pn2\|1pn2]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [~~http~~://pdbe.org/1pn4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1pn4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [https://pdbe.org/1pn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [https://www.ebi.ac.uk/pdbsum/1pn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR]] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.	+	[[https://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR]] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:57, 24 July 2019

2019-07-24T06:57:05Z

←Older revision		Revision as of 06:57, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.==		==Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.==
-	<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='1pn4' size='340' side='right'caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_4563 Atcc 4563]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_4563 Atcc 4563]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 4563]]		[[Category: Atcc 4563]]
		+	[[Category: Large Structures]]
	[[Category: Glumoff, T]]		[[Category: Glumoff, T]]
	[[Category: Haapalainen, A M]]		[[Category: Haapalainen, A M]]

OCA at 08:33, 24 February 2018

2018-02-24T08:33:10Z

←Older revision		Revision as of 08:33, 24 February 2018
Line 1:		Line 1:
		+
	==Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.==		==Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.==
	<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://pdbe.org/1pn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://pdbe.org/1pn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pn4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pn4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pn4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:18, 8 February 2016

2016-02-08T12:18:45Z

←Older revision		Revision as of 12:18, 8 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pn4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:30, 10 September 2015

2015-09-10T11:30:07Z

←Older revision		Revision as of 11:30, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Candida_tropicalis Candida tropicalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_4563 Atcc 4563]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ~~Candida tropicalis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 ATCC 4563])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://pdbe.org/1pn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1pn4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Candida tropicalis~~]]	+	[[Category: Atcc 4563]]
	[[Category: Glumoff, T]]		[[Category: Glumoff, T]]
	[[Category: Haapalainen, A M]]		[[Category: Haapalainen, A M]]

OCA at 23:15, 24 December 2014

2014-12-24T23:15:44Z

←Older revision		Revision as of 23:15, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 Candida tropicalis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 Candida tropicalis])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR]] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Candida tropicalis]]		[[Category: Candida tropicalis]]
-	[[Category: Glumoff, T.]]	+	[[Category: Glumoff, T]]
-	[[Category: Haapalainen, A M.]]	+	[[Category: Haapalainen, A M]]
-	[[Category: Hiltunen, J K.]]	+	[[Category: Hiltunen, J K]]
-	[[Category: Koski, M K.]]	+	[[Category: Koski, M K]]
	[[Category: Enzyme-product complex]]		[[Category: Enzyme-product complex]]
	[[Category: Hot-dog fold]]		[[Category: Hot-dog fold]]

OCA at 20:41, 28 September 2014

2014-09-28T20:41:19Z

←Older revision		Revision as of 20:41, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1pn4.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.==
		+	<StructureSection load='1pn4' size='340' side='right' caption='[[1pn4]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PN4 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HDC:3R-HYDROXYDECANOYL-COENZYME+A'>HDC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1pn2\|1pn2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5482 Candida tropicalis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pn4 RCSB], [http://www.ebi.ac.uk/pdbsum/1pn4 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/1pn4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	2-Enoyl-CoA hydratase 2, a part from multifunctional enzyme type 2, hydrates trans-2-enoyl-CoA to 3-hydroxyacyl-CoA in the (3R)-hydroxy-dependent route of peroxisomal beta-oxidation of fatty acids. Unliganded and (3R)-hydroxydecanoyl coenzyme A-complexed crystal structures of 2-enoyl-CoA hydratase 2 from Candida tropicalis multifunctional enzyme type 2 were solved to 1.95- and 2.35-A resolution, respectively. 2-Enoyl-CoA hydratase 2 is a dimeric, alpha+beta protein with a novel quaternary structure. The overall structure of the two-domain subunit of eukaryotic 2-enoyl-CoA hydratase 2 resembles the homodimeric, hot dog fold structures of prokaryotic (R)-specific 2-enoyl-CoA hydratase and beta-hydroxydecanoyl thiol ester dehydrase. Importantly, though, the eukaryotic hydratase 2 has a complete hot dog fold only in its C-domain, whereas the N-domain lacks a long central alpha-helix, thus creating space for bulkier substrates in the binding pocket and explaining the observed difference in substrate preference between eukaryotic and prokaryotic enzymes. Although the N- and C-domains have an identity of <10% at the amino acid level, they share a 50% identity at the nucleotide level and fold similarly. We suggest that a subunit of 2-enoyl-CoA hydratase 2 has evolved via a gene duplication with the concomitant loss of one catalytic site. The hydrogen bonding network of the active site of 2-enoyl-CoA hydratase 2 resembles the active site geometry of mitochondrial (S)-specific 2-enoyl-CoA hydratase 1, although in a mirror image fashion. This arrangement allows the reaction to occur by similar mechanism, supported by mutagenesis and mechanistic studies, although via reciprocal stereochemistry.

-	~~{{STRUCTURE_1pn4\| PDB=1pn4 \| SCENE= }}~~	+	A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2.,Koski MK, Haapalainen AM, Hiltunen JK, Glumoff T J Biol Chem. 2004 Jun 4;279(23):24666-72. Epub 2004 Mar 29. PMID:15051722<ref>PMID:15051722</ref>

-	~~===Crystal structure~~ of ~~2-enoyl-CoA hydratase 2 domain~~ of ~~Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15051722}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1pn4]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015051722<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Candida tropicalis]]		[[Category: Candida tropicalis]]
	[[Category: Glumoff, T.]]		[[Category: Glumoff, T.]]

OCA: Protected "1pn4" [edit=sysop:move=sysop]

2012-12-19T12:10:54Z

Protected "1pn4" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 19 December 2012

OCA at 12:10, 19 December 2012

2012-12-19T12:10:51Z

←Older revision		Revision as of 12:10, 19 December 2012
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-	{{Seed}}
	[[Image:1pn4.png\|left\|200px]]		[[Image:1pn4.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1pn4\| PDB=1pn4 \| SCENE= }}		{{STRUCTURE_1pn4\| PDB=1pn4 \| SCENE= }}

	===Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.===		===Crystal structure of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis multifunctional enzyme type 2 complexed with (3R)-hydroxydecanoyl-CoA.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15051722}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15051722 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15051722}}		{{ABSTRACT_PUBMED_15051722}}

	==About this Structure==		==About this Structure==
-	~~1PN4~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA].	+	[[1pn4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PN4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15051722~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015051722</ref><references group="xtra"/>
	[[Category: Candida tropicalis]]		[[Category: Candida tropicalis]]
	[[Category: Glumoff, T.]]		[[Category: Glumoff, T.]]
Line 32:		Line 20:
	[[Category: Hot-dog fold]]		[[Category: Hot-dog fold]]
	[[Category: Hydratase 2 motif]]		[[Category: Hydratase 2 motif]]
		+	[[Category: Lyase]]
	[[Category: Oxyanion hole]]		[[Category: Oxyanion hole]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:56:48 2009''