1psj - Revision history

OCA at 05:58, 17 April 2024

2024-04-17T05:58:48Z

←Older revision		Revision as of 05:58, 17 April 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [https://pdbe.org/1psj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [https://www.ebi.ac.uk/pdbsum/1psj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [https://pdbe.org/1psj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [https://www.ebi.ac.uk/pdbsum/1psj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>	+	[https://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psj ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed.
-
-	Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution.,Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:8636969<ref>PMID:8636969</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 29:
	[[Category: Gloydius halys]]		[[Category: Gloydius halys]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lin~~, Z J~~]]	+	[[Category: Lin ZJ]]
-	[[Category: Wang~~, X Q]]~~	+	[[Category: Wang XQ]]
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lipid degradation~~]]	+

OCA at 09:34, 8 September 2021

2021-09-08T09:34:13Z

←Older revision		Revision as of 09:34, 8 September 2021
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	<StructureSection load='1psj' size='340' side='right'caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1psj' size='340' side='right'caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [~~http~~://pdbe.org/1psj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1psj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [https://pdbe.org/1psj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [https://www.ebi.ac.uk/pdbsum/1psj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>	+	[[https://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:46, 27 November 2019

2019-11-27T09:46:55Z

←Older revision		Revision as of 09:46, 27 November 2019
Line 1:		Line 1:

	==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==		==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==
-	<StructureSection load='1psj' size='340' side='right' caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1psj' size='340' side='right'caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase A2 3D structures\|Phospholipase A2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Gloydius halys]]		[[Category: Gloydius halys]]
		+	[[Category: Large Structures]]
	[[Category: Lin, Z J]]		[[Category: Lin, Z J]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]

OCA at 07:53, 24 February 2018

2018-02-24T07:53:57Z

←Older revision		Revision as of 07:53, 24 February 2018
Line 1:		Line 1:
		+
	==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==		==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==
	<StructureSection load='1psj' size='340' side='right' caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1psj' size='340' side='right' caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://pdbe.org/1psj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://pdbe.org/1psj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1psj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1psj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1psj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phospholipase A2\|Phospholipase A2]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 36:
	[[Category: Lin, Z J]]		[[Category: Lin, Z J]]
	[[Category: Wang, X Q]]		[[Category: Wang, X Q]]
		+	[[Category: Calcium]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lipid degradation]]		[[Category: Lipid degradation]]

OCA at 22:48, 11 September 2015

2015-09-11T22:48:38Z

←Older revision		Revision as of 22:48, 11 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://pdbe.org/1psj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~PA21B_AGKHP PA21B_AGKHP~~]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, or thrombin~~-induced~~. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>	+	[[http://www.uniprot.org/uniprot/PA2A_GLOHA PA2A_GLOHA]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, and thrombin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1psj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 20:28, 25 December 2014

2014-12-25T20:28:50Z

←Older revision		Revision as of 20:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA21B_AGKHP PA21B_AGKHP]] Snake venom phospholipase A2 (PLA2) that acts in vivo as an anti-thrombotic agent. Inhibits platelet aggregation induced by ADP, arachidonic acid, or thrombin-induced. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18456297</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Gloydius halys]]		[[Category: Gloydius halys]]
-	[[Category: Lin, Z J.]]	+	[[Category: Lin, Z J]]
-	[[Category: Wang, X Q.]]	+	[[Category: Wang, X Q]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lipid degradation]]		[[Category: Lipid degradation]]

OCA at 21:32, 28 September 2014

2014-09-28T21:32:07Z

←Older revision		Revision as of 21:32, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1psj.~~png\|left~~\|200px]]	+	==ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS==
		+	<StructureSection load='1psj' size='340' side='right' caption='[[1psj]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PSJ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1psj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1psj RCSB], [http://www.ebi.ac.uk/pdbsum/1psj PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1psj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of acidic phospholipase A2 from the venom of Agkistrodon halys pallas has been determined by molecular replacement at 2.0 A resolution to a crystallographic R-factor of 0.157. The overall structure of the molecule is very similar to those of other phospholipase A2 species of known structure. The catalytic site, the hydrophobic channel and the N-terminal region show greatest structural conservation. The Ca(2+)-binding region has a conformation that resembles closely that of bovine PLA2 rather than Crotalus atrox PLA2. Compared with other PLA2 species, the conformation of the C-terminal ridge shows significant difference due to the insertion of two residues. A unique aromatic patch appears on one face of the molecules, surrounded by two acidic residues, the relevant features of this structure and their possible biological implications are discussed.

-	~~{{STRUCTURE_1psj\| PDB=1psj \| SCENE= }}~~	+	Crystal structure of an acidic phospholipase A2 from the venom of Agkistrodon halys pallas at 2.0 A resolution.,Wang XQ, Yang J, Gui LL, Lin ZJ, Chen YC, Zhou YC J Mol Biol. 1996 Feb 9;255(5):669-76. PMID:8636969<ref>PMID:8636969</ref>

-	~~===ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8636969}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1psj]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gloydius_halys Gloydius halys]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].~~	+

	==See Also==		==See Also==
	*[[Phospholipase A2\|Phospholipase A2]]		*[[Phospholipase A2\|Phospholipase A2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:008636969<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gloydius halys]]		[[Category: Gloydius halys]]
	[[Category: Lin, Z J.]]		[[Category: Lin, Z J.]]

OCA at 21:07, 20 October 2012

2012-10-20T21:07:09Z

←Older revision		Revision as of 21:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1psj]] is a 1 chain structure ~~of [[Phospholipase A2]]~~ with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].	+	[[1psj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].

	==See Also==		==See Also==

OCA: Protected "1psj" [edit=sysop:move=sysop]

2012-07-27T12:38:52Z

Protected "1psj" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 27 July 2012

OCA at 12:38, 27 July 2012

2012-07-27T12:38:49Z

←Older revision		Revision as of 12:38, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1psj.png\|left\|200px]]		[[Image:1psj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1psj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1psj\| PDB=1psj \| SCENE= }}		{{STRUCTURE_1psj\| PDB=1psj \| SCENE= }}

	===ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS===		===ACIDIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8636969}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8636969 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8636969}}		{{ABSTRACT_PUBMED_8636969}}

	==About this Structure==		==About this Structure==
-	~~1PSJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].	+	[[1psj]] is a 1 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Gloydius_halys Gloydius halys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSJ OCA].
		+
		+	==See Also==
		+	*[[Phospholipase A2\|Phospholipase A2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8636969~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008636969</ref><references group="xtra"/>
	[[Category: Gloydius halys]]		[[Category: Gloydius halys]]
	[[Category: Lin, Z J.]]		[[Category: Lin, Z J.]]
	[[Category: Wang, X Q.]]		[[Category: Wang, X Q.]]
-	[[Category: Calcium]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lipid degradation]]		[[Category: Lipid degradation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:15:53 2009''