1qcc - Revision history

OCA at 08:14, 14 February 2024

2024-02-14T08:14:59Z

←Older revision		Revision as of 08:14, 14 February 2024
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	<StructureSection load='1qcc' size='340' side='right'caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='1qcc' size='340' side='right'caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Leido Leido~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [https://pdbe.org/1qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [https://www.ebi.ac.uk/pdbsum/1qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [https://pdbe.org/1qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [https://www.ebi.ac.uk/pdbsum/1qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q27679_LEIDO Q27679_LEIDO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qcc ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qcc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis.
-
-	Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.,Phillips CL, Ullman B, Brennan RG, Hill CP EMBO J. 1999 Jul 1;18(13):3533-45. PMID:10393170<ref>PMID:10393170</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]		*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leido~~]]	+	[[Category: Leishmania donovani]]
-	[[Category: Brennan~~, R G~~]]	+	[[Category: Brennan RG]]
-	[[Category: Hill~~, C P~~]]	+	[[Category: Hill CP]]
-	[[Category: Phillips~~, C L~~]]	+	[[Category: Phillips CL]]
-	[[Category: Ullman, B]]	+	[[Category: Ullman B]]
-	~~[[Category: Dinucleotide binding fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:53, 15 September 2021

2021-09-15T09:53:24Z

←Older revision		Revision as of 09:53, 15 September 2021
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	<StructureSection load='1qcc' size='340' side='right'caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='1qcc' size='340' side='right'caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [~~http~~://pdbe.org/1qcc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qcc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [https://pdbe.org/1qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [https://www.ebi.ac.uk/pdbsum/1qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:23, 27 November 2019

2019-11-27T10:23:41Z

←Older revision		Revision as of 10:23, 27 November 2019
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	==CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI==		==CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI==
-	<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='1qcc' size='340' side='right'caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
Line 26:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Leido]]		[[Category: Leido]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]

OCA at 08:23, 24 February 2018

2018-02-24T08:23:13Z

←Older revision		Revision as of 08:23, 24 February 2018
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		+
	==CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI==		==CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI==
	<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://pdbe.org/1qcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://pdbe.org/1qcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qcc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qcc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 26:
	</div>		</div>
	<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:00, 10 February 2016

2016-02-10T02:00:01Z

←Older revision		Revision as of 02:00, 10 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qcc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:15, 11 September 2015

2015-09-11T04:15:28Z

←Older revision		Revision as of 04:15, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Leishmania_donovani Leishmania donovani~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leido Leido]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://pdbe.org/1qcc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qcc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Leishmania donovani~~]]	+	[[Category: Leido]]
	[[Category: Brennan, R G]]		[[Category: Brennan, R G]]
	[[Category: Hill, C P]]		[[Category: Hill, C P]]

OCA at 08:19, 6 January 2015

2015-01-06T08:19:07Z

←Older revision		Revision as of 08:19, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Leishmania donovani]]		[[Category: Leishmania donovani]]
-	[[Category: Brennan, R G.]]	+	[[Category: Brennan, R G]]
-	[[Category: Hill, C P.]]	+	[[Category: Hill, C P]]
-	[[Category: Phillips, C L.]]	+	[[Category: Phillips, C L]]
-	[[Category: Ullman, B.]]	+	[[Category: Ullman, B]]
	[[Category: Dinucleotide binding fold]]		[[Category: Dinucleotide binding fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:49, 3 October 2014

2014-10-03T11:49:09Z

←Older revision		Revision as of 11:49, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1qcc\| PDB=1qcc \| SCENE= }}~~	+	==CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI==
-	===CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI===	+	<StructureSection load='1qcc' size='340' side='right' caption='[[1qcc]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10393170}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QCC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qcc RCSB], [http://www.ebi.ac.uk/pdbsum/1qcc PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qcc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis.

-	~~==About this Structure==~~	+	Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.,Phillips CL, Ullman B, Brennan RG, Hill CP EMBO J. 1999 Jul 1;18(13):3533-45. PMID:10393170<ref>PMID:10393170</ref>
-	~~[[1qcc]] is a 1 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Leishmania_donovani~~ Leishmania donovani]. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1QCC OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:010393170</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Leishmania donovani]]		[[Category: Leishmania donovani]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA at 10:48, 16 April 2014

2014-04-16T10:48:38Z

←Older revision		Revision as of 10:48, 16 April 2014
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	{{STRUCTURE_1qcc\| PDB=1qcc \| SCENE= }}		{{STRUCTURE_1qcc\| PDB=1qcc \| SCENE= }}
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	===CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI===		===CRYSTAL STRUCTURES OF ADENINE PHOSPHORIBOSYLTRANSFERASE FROM LEISHMANIA DONOVANI===
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	{{ABSTRACT_PUBMED_10393170}}		{{ABSTRACT_PUBMED_10393170}}

	==About this Structure==		==About this Structure==
	[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA].		[[1qcc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCC OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010393170</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010393170</ref><references group="xtra"/><references/>
	[[Category: Leishmania donovani]]		[[Category: Leishmania donovani]]
	[[Category: Brennan, R G.]]		[[Category: Brennan, R G.]]

OCA: Protected "1qcc" [edit=sysop:move=sysop]

2012-06-02T09:30:37Z

Protected "1qcc" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:30, 2 June 2012