1qtu - Revision history

OCA at 06:07, 17 April 2024

2024-04-17T06:07:16Z

←Older revision		Revision as of 06:07, 17 April 2024
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==		==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
-	<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1a1x\|1a1x]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.	+	[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>	+	[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Two related oncogenes, TCL1 and MTCP1, are overexpressed in certain T-cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, respectively. The human oncoprotein p13MTCP1 is coded by the MTCP1 gene and its primary sequence is highly and only homologous to that of p14TCL1, the product of TCL1. These two proteins likely represent the first members of a new family of oncogenic proteins. A previous model of the three-dimensional solution structure of p13MTCP1 was determined recently using exclusively homonuclear proton two-dimensional NMR methods and, almost simultaneously, high-resolution crystal structures of p13MTCP1 and p14TCL1 appeared in the literature. In order to gain more insight into the details of the solution structure, we uniformly labeled p13MTCP1 with nitrogen-15. The refined structure benefits from 520 additional NOEs, extracted from either 15N-edited 3D experiments or homonuclear 2D NOESY recorded at 800 MHz, and from a nearly complete set of phi angular restraints. Measurements of 15N spin relaxation times and heteronuclear 15N[1H]NOEs at two magnetic field strengths provided additional insights into the dynamics of the protein backbone. On the basis of these new results, a putative binding surface for this particular class of oncogenes is discussed.
-
-	Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.,Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C J Biomol NMR. 2000 Jul;17(3):215-30. PMID:10959629<ref>PMID:10959629</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qtu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guignard, L]]	+	[[Category: Guignard L]]
-	[[Category: Lhoste, J M]]	+	[[Category: Lhoste J-M]]
-	[[Category: Mispelter, J]]	+	[[Category: Mispelter J]]
-	[[Category: Padilla, A]]	+	[[Category: Padilla A]]
-	[[Category: Roumestand, C]]	+	[[Category: Roumestand C]]
-	[[Category: Stern, M H]]	+	[[Category: Stern M-H]]
-	[[Category: Yang, Y S]]	+	[[Category: Yang Y-S]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Gene regulation~~]]	+

OCA at 10:04, 15 September 2021

2021-09-15T10:04:12Z

←Older revision		Revision as of 10:04, 15 September 2021
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	<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QTU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a1x\|1a1x]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [~~http~~://pdbe.org/1qtu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.	+	[[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>	+	[[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:37, 4 December 2019

2019-12-04T11:37:46Z

←Older revision		Revision as of 11:37, 4 December 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==		==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
-	<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Guignard, L]]		[[Category: Guignard, L]]
	[[Category: Lhoste, J M]]		[[Category: Lhoste, J M]]

OCA at 18:40, 24 January 2018

2018-01-24T18:40:03Z

←Older revision		Revision as of 18:40, 24 January 2018
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==		==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
	<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://pdbe.org/1qtu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://pdbe.org/1qtu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Guignard, L]]		[[Category: Guignard, L]]
-	[[Category: Lhoste, J-M]]	+	[[Category: Lhoste, J M]]
	[[Category: Mispelter, J]]		[[Category: Mispelter, J]]
	[[Category: Padilla, A]]		[[Category: Padilla, A]]
	[[Category: Roumestand, C]]		[[Category: Roumestand, C]]
-	[[Category: Stern, M-H]]	+	[[Category: Stern, M H]]
-	[[Category: Yang, Y-S]]	+	[[Category: Yang, Y S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]

OCA at 04:51, 9 February 2016

2016-02-09T04:51:51Z

←Older revision		Revision as of 04:51, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:47, 10 September 2015

2015-09-10T18:47:56Z

←Older revision		Revision as of 18:47, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://pdbe.org/1qtu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qtu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Guignard, L]]		[[Category: Guignard, L]]
	[[Category: Lhoste, J-M]]		[[Category: Lhoste, J-M]]

OCA at 08:14, 6 January 2015

2015-01-06T08:14:54Z

←Older revision		Revision as of 08:14, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.		[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Guignard, L.]]	+	[[Category: Guignard, L]]
-	[[Category: Lhoste, J-M.]]	+	[[Category: Lhoste, J-M]]
-	[[Category: Mispelter, J.]]	+	[[Category: Mispelter, J]]
-	[[Category: Padilla, A.]]	+	[[Category: Padilla, A]]
-	[[Category: Roumestand, C.]]	+	[[Category: Roumestand, C]]
-	[[Category: Stern, M-H.]]	+	[[Category: Stern, M-H]]
-	[[Category: Yang, Y-S.]]	+	[[Category: Yang, Y-S]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]

OCA at 15:39, 29 September 2014

2014-09-29T15:39:38Z

←Older revision		Revision as of 15:39, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1qtu\| PDB=1qtu \| SCENE= }}~~	+	==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
-	===SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1===	+	<StructureSection load='1qtu' size='340' side='right' caption='[[1qtu]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
-	~~{{ABSTRACT_PUBMED_10959629}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a1x\|1a1x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [http://www.ebi.ac.uk/pdbsum/1qtu PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.		[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two related oncogenes, TCL1 and MTCP1, are overexpressed in certain T-cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, respectively. The human oncoprotein p13MTCP1 is coded by the MTCP1 gene and its primary sequence is highly and only homologous to that of p14TCL1, the product of TCL1. These two proteins likely represent the first members of a new family of oncogenic proteins. A previous model of the three-dimensional solution structure of p13MTCP1 was determined recently using exclusively homonuclear proton two-dimensional NMR methods and, almost simultaneously, high-resolution crystal structures of p13MTCP1 and p14TCL1 appeared in the literature. In order to gain more insight into the details of the solution structure, we uniformly labeled p13MTCP1 with nitrogen-15. The refined structure benefits from 520 additional NOEs, extracted from either 15N-edited 3D experiments or homonuclear 2D NOESY recorded at 800 MHz, and from a nearly complete set of phi angular restraints. Measurements of 15N spin relaxation times and heteronuclear 15N[1H]NOEs at two magnetic field strengths provided additional insights into the dynamics of the protein backbone. On the basis of these new results, a putative binding surface for this particular class of oncogenes is discussed.

-	~~==Function==~~	+	Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.,Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C J Biomol NMR. 2000 Jul;17(3):215-30. PMID:10959629<ref>PMID:10959629</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2~~.<ref>PMID:~~10983986~~</ref>	+
-		+
-	~~==About this Structure==~~	+
-	[[1qtu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA].	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:010959629</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guignard, L.]]		[[Category: Guignard, L.]]

OCA at 02:44, 25 March 2013

2013-03-25T02:44:15Z

←Older revision		Revision as of 02:44, 25 March 2013
Line 1:		Line 1:
-	[[Image:1qtu.png\|left\|200px]]
-
	{{STRUCTURE_1qtu\| PDB=1qtu \| SCENE= }}		{{STRUCTURE_1qtu\| PDB=1qtu \| SCENE= }}
-
	===SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1===		===SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1===
		+	{{ABSTRACT_PUBMED_10959629}}

-	~~{{ABSTRACT_PUBMED_10959629}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN]] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:010959629</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010959629</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Guignard, L.]]		[[Category: Guignard, L.]]

OCA: Protected "1qtu" [edit=sysop:move=sysop]

2013-01-02T09:53:06Z

Protected "1qtu" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:53, 2 January 2013