1qu7 - Revision history

OCA at 08:17, 14 February 2024

2024-02-14T08:17:44Z

←Older revision		Revision as of 08:17, 14 February 2024
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	<StructureSection load='1qu7' size='340' side='right'caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1qu7' size='340' side='right'caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [https://pdbe.org/1qu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1qu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu7 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [https://pdbe.org/1qu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1qu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MCP1_ECOLI MCP1_ECOLI]] Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.	+	[https://www.uniprot.org/uniprot/MCP1_ECOLI MCP1_ECOLI] Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qu7 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qu7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The bacterial chemotaxis receptors are transmembrane receptors with a simple signalling pathway which has elements relevant to the general understanding of signal recognition and transduction across membranes, how signals are relayed between molecules in a pathway, and how adaptation to a persistent signal is achieved. In contrast to many mammalian receptors which signal by oligomerizing upon ligand binding, the chemotaxis receptors are dimeric even in the absence of their ligands, and their signalling does not depend on a monomer-dimer equilibrium. Bacterial chemotaxis receptors are composed of a ligand-binding domain, a transmembrane domain consisting of two helices TM1 and TM2, and a cytoplasmic domain. All known bacterial chemotaxis receptors have a highly conserved cytoplasmic domain, which unites signals from different ligand domains into a single signalling pathway to flagella motors. Here we report the crystal structure of the cytoplasmic domain of a serine chemotaxis receptor of Escherichia coli, which reveals a 200 A-long coiled-coil of two antiparallel helices connected by a 'U-turn'. Two of these domains form a long, supercoiled, four-helical bundle in the cytoplasmic portion of the receptor.
-
-	Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor.,Kim KK, Yokota H, Kim SH Nature. 1999 Aug 19;400(6746):787-92. PMID:10466731<ref>PMID:10466731</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1qu7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]		*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kim~~, K K~~]]	+	[[Category: Kim KK]]
-	[[Category: Kim, S H]]	+	[[Category: Kim S-H]]
-	[[Category: Yokota, H]]	+	[[Category: Yokota H]]
-	~~[[Category: Chemotaxis]]~~	+
-	~~[[Category: Four helical-bundle]]~~	+
-	~~[[Category: Serine]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:04, 15 September 2021

2021-09-15T10:04:33Z

←Older revision		Revision as of 10:04, 15 September 2021
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	<StructureSection load='1qu7' size='340' side='right'caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1qu7' size='340' side='right'caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [~~http~~://pdbe.org/1qu7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1qu7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu7 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [https://pdbe.org/1qu7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [https://www.ebi.ac.uk/pdbsum/1qu7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MCP1_ECOLI MCP1_ECOLI]] Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.	+	[[https://www.uniprot.org/uniprot/MCP1_ECOLI MCP1_ECOLI]] Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]		*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
-	*[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor\|Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:53, 4 December 2019

2019-12-04T11:53:41Z

←Older revision		Revision as of 11:53, 4 December 2019
Line 1:		Line 1:

	==FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR==		==FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR==
-	<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='1qu7' size='340' side='right'caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Chemotaxis protein\|Chemotaxis protein]]	+	*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
	*[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor\|Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]		*[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor\|Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Kim, S H]]		[[Category: Kim, S H]]

OCA at 08:17, 28 February 2018

2018-02-28T08:17:38Z

←Older revision		Revision as of 08:17, 28 February 2018
Line 1:		Line 1:
		+
	==FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR==		==FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR==
	<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://pdbe.org/1qu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://pdbe.org/1qu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1qu7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1qu7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qu7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	*[[Chemotaxis protein\|Chemotaxis protein]]		*[[Chemotaxis protein\|Chemotaxis protein]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
		+	*[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor\|Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:15, 11 September 2015

2015-09-11T17:15:41Z

←Older revision		Revision as of 17:15, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://pdbe.org/1qu7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1qu7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Kim, K K]]		[[Category: Kim, K K]]
	[[Category: Kim, S H]]		[[Category: Kim, S H]]

OCA at 19:29, 25 December 2014

2014-12-25T19:29:50Z

←Older revision		Revision as of 19:29, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MCP1_ECOLI MCP1_ECOLI]] Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Kim, K K.]]	+	[[Category: Kim, K K]]
-	[[Category: Kim, S H.]]	+	[[Category: Kim, S H]]
-	[[Category: Yokota, H.]]	+	[[Category: Yokota, H]]
	[[Category: Chemotaxis]]		[[Category: Chemotaxis]]
	[[Category: Four helical-bundle]]		[[Category: Four helical-bundle]]
	[[Category: Serine]]		[[Category: Serine]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 14:21, 29 September 2014

2014-09-29T14:21:26Z

←Older revision		Revision as of 14:21, 29 September 2014
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-	~~{{STRUCTURE_1qu7\| PDB=1qu7 \| SCENE= }}~~	+	==FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR==
-	===FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR===	+	<StructureSection load='1qu7' size='340' side='right' caption='[[1qu7]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_10466731}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QU7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qu7 RCSB], [http://www.ebi.ac.uk/pdbsum/1qu7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1qu7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial chemotaxis receptors are transmembrane receptors with a simple signalling pathway which has elements relevant to the general understanding of signal recognition and transduction across membranes, how signals are relayed between molecules in a pathway, and how adaptation to a persistent signal is achieved. In contrast to many mammalian receptors which signal by oligomerizing upon ligand binding, the chemotaxis receptors are dimeric even in the absence of their ligands, and their signalling does not depend on a monomer-dimer equilibrium. Bacterial chemotaxis receptors are composed of a ligand-binding domain, a transmembrane domain consisting of two helices TM1 and TM2, and a cytoplasmic domain. All known bacterial chemotaxis receptors have a highly conserved cytoplasmic domain, which unites signals from different ligand domains into a single signalling pathway to flagella motors. Here we report the crystal structure of the cytoplasmic domain of a serine chemotaxis receptor of Escherichia coli, which reveals a 200 A-long coiled-coil of two antiparallel helices connected by a 'U-turn'. Two of these domains form a long, supercoiled, four-helical bundle in the cytoplasmic portion of the receptor.

-	~~==About this Structure==~~	+	Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor.,Kim KK, Yokota H, Kim SH Nature. 1999 Aug 19;400(6746):787-92. PMID:10466731<ref>PMID:10466731</ref>
-	~~[[1qu7]] is a 2 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1QU7 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Chemotaxis protein\|Chemotaxis protein]]		*[[Chemotaxis protein\|Chemotaxis protein]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010466731<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kim, K K.]]		[[Category: Kim, K K.]]

OCA at 09:38, 11 March 2013

2013-03-11T09:38:52Z

←Older revision		Revision as of 09:38, 11 March 2013
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-	[[Image:1qu7.png\|left\|200px]]
-
	{{STRUCTURE_1qu7\| PDB=1qu7 \| SCENE= }}		{{STRUCTURE_1qu7\| PDB=1qu7 \| SCENE= }}
-
	===FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR===		===FOUR HELICAL-BUNDLE STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A SERINE CHEMOTAXIS RECEPTOR===
-
	{{ABSTRACT_PUBMED_10466731}}		{{ABSTRACT_PUBMED_10466731}}

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	*[[Chemotaxis protein\|Chemotaxis protein]]		*[[Chemotaxis protein\|Chemotaxis protein]]
	*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]		*[[Methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis protein]]
-	*[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor\|Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]

	==Reference==		==Reference==

OCA at 20:33, 20 October 2012

2012-10-20T20:33:21Z

←Older revision		Revision as of 20:33, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1qu7]] is a 2 chain structure ~~of [[Methyl-accepting chemotaxis protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA].	+	[[1qu7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU7 OCA].

	==See Also==		==See Also==

OCA: Protected "1qu7" [edit=sysop:move=sysop]

2012-07-27T10:53:03Z

Protected "1qu7" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:53, 27 July 2012