1r5w - Revision history

OCA at 06:10, 17 April 2024

2024-04-17T06:10:05Z

←Older revision		Revision as of 06:10, 17 April 2024
Line 3:		Line 3:
	<StructureSection load='1r5w' size='340' side='right'caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1r5w' size='340' side='right'caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R5W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [https://pdbe.org/1r5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [https://www.ebi.ac.uk/pdbsum/1r5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5w ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [https://pdbe.org/1r5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [https://www.ebi.ac.uk/pdbsum/1r5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5w ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HA22_MOUSE HA22_MOUSE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5w ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	While in many cases the half-life of T cell receptor (TCR) binding to a particular ligand is a good predictor of activation potential, numerous exceptions suggest that other physical parameter(s) must also play a role. Accordingly, we analyzed the thermodynamics of TCR binding to a series of peptide-MHC ligands, three of which are more stimulatory than their stability of binding would predict. Strikingly, we find that during TCR binding these outliers show anomalously large changes in heat capacity, an indicator of conformational change or flexibility in a binding interaction. By combining the values for heat capacity (DeltaCp) and the half-life of TCR binding (t(1/2)), we find that we can accurately predict the degree of T cell stimulation. Structural analysis shows significant changes in the central TCR contact residue of the peptide-MHC, indicating that structural rearrangements within the TCR-peptide-MHC interface can contribute to T cell activation.
-
-	Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.,Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM Mol Cell. 2003 Dec;12(6):1367-78. PMID:14690592<ref>PMID:14690592</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1r5w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
-	~~== References ==~~	+	*[[MHC II 3D structures\|MHC II 3D structures]]
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Adams, E]]	+	[[Category: Adams E]]
-	[[Category: Chow~~, D C~~]]	+	[[Category: Chow DC]]
-	[[Category: Davis~~, M M~~]]	+	[[Category: Davis MM]]
-	[[Category: Garcia~~, K C~~]]	+	[[Category: Garcia KC]]
-	[[Category: He, X]]	+	[[Category: He X]]
-	[[Category: Krogsgaard, M]]	+	[[Category: Krogsgaard M]]
-	[[Category: Prado, N]]	+	[[Category: Prado N]]
-	[[Category: Wilson~~, D B]]~~	+	[[Category: Wilson DB]]
-	~~[[Category: Mhc class ii]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Structural rearangement]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 10:08, 15 September 2021

2021-09-15T10:08:32Z

←Older revision		Revision as of 10:08, 15 September 2021
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	<StructureSection load='1r5w' size='340' side='right'caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1r5w' size='340' side='right'caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1R5W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [~~http~~://pdbe.org/1r5w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1r5w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5w ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [https://pdbe.org/1r5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [https://www.ebi.ac.uk/pdbsum/1r5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5w ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:49, 4 December 2019

2019-12-04T11:49:13Z

←Older revision		Revision as of 11:49, 4 December 2019
Line 1:		Line 1:

	==Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation==		==Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation==
-	<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='1r5w' size='340' side='right'caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Adams, E]]		[[Category: Adams, E]]

OCA at 08:13, 28 February 2018

2018-02-28T08:13:07Z

←Older revision		Revision as of 08:13, 28 February 2018
Line 1:		Line 1:
		+
	==Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation==		==Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation==
	<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://pdbe.org/1r5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://pdbe.org/1r5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5w ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r5w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r5w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:59, 9 February 2016

2016-02-09T17:59:48Z

←Older revision		Revision as of 17:59, 9 February 2016
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:39, 11 September 2015

2015-09-11T00:39:56Z

←Older revision		Revision as of 00:39, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://pdbe.org/1r5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1r5w" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Adams, E]]		[[Category: Adams, E]]
	[[Category: Chow, D C]]		[[Category: Chow, D C]]

OCA at 07:31, 6 January 2015

2015-01-06T07:31:41Z

←Older revision		Revision as of 07:31, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>		<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Adams, E.]]	+	[[Category: Adams, E]]
-	[[Category: Chow, D C.]]	+	[[Category: Chow, D C]]
-	[[Category: Davis, M M.]]	+	[[Category: Davis, M M]]
-	[[Category: Garcia, K C.]]	+	[[Category: Garcia, K C]]
-	[[Category: He, X.]]	+	[[Category: He, X]]
-	[[Category: Krogsgaard, M.]]	+	[[Category: Krogsgaard, M]]
-	[[Category: Prado, N.]]	+	[[Category: Prado, N]]
-	[[Category: Wilson, D B.]]	+	[[Category: Wilson, D B]]
	[[Category: Mhc class ii]]		[[Category: Mhc class ii]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural rearangement]]		[[Category: Structural rearangement]]
	[[Category: Tcr]]		[[Category: Tcr]]

OCA at 21:23, 28 September 2014

2014-09-28T21:23:15Z

←Older revision		Revision as of 21:23, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1r5w.~~png\|left~~\|200px]]	+	==Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation==
		+	<StructureSection load='1r5w' size='340' side='right' caption='[[1r5w]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R5W FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r5w RCSB], [http://www.ebi.ac.uk/pdbsum/1r5w PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r5w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	While in many cases the half-life of T cell receptor (TCR) binding to a particular ligand is a good predictor of activation potential, numerous exceptions suggest that other physical parameter(s) must also play a role. Accordingly, we analyzed the thermodynamics of TCR binding to a series of peptide-MHC ligands, three of which are more stimulatory than their stability of binding would predict. Strikingly, we find that during TCR binding these outliers show anomalously large changes in heat capacity, an indicator of conformational change or flexibility in a binding interaction. By combining the values for heat capacity (DeltaCp) and the half-life of TCR binding (t(1/2)), we find that we can accurately predict the degree of T cell stimulation. Structural analysis shows significant changes in the central TCR contact residue of the peptide-MHC, indicating that structural rearrangements within the TCR-peptide-MHC interface can contribute to T cell activation.

-	~~{{STRUCTURE_1r5w\| PDB=1r5w \| SCENE= }}~~	+	Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.,Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM Mol Cell. 2003 Dec;12(6):1367-78. PMID:14690592<ref>PMID:14690592</ref>

-	~~===Evidence that structural rearrangements and~~/~~or flexibility during TCR binding can contribute to T-cell activation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_14690592}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1r5w]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA].~~	+

	==See Also==		==See Also==
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014690592<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Adams, E.]]		[[Category: Adams, E.]]

OCA at 14:39, 20 October 2012

2012-10-20T14:39:14Z

←Older revision		Revision as of 14:39, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1r5w]] is a 6 chain structure ~~of [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA].	+	[[1r5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5W OCA].

	==See Also==		==See Also==

OCA: Protected "1r5w" [edit=sysop:move=sysop]

2012-07-26T15:49:11Z

Protected "1r5w" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:49, 26 July 2012