1rb5 - Revision history

OCA at 11:24, 2 August 2023

2023-08-02T11:24:41Z

←Older revision		Revision as of 11:24, 2 August 2023
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	<StructureSection load='1rb5' size='340' side='right'caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1rb5' size='340' side='right'caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ACE:ACETYL+GROUP'>ACE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [https://pdbe.org/1rb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1rb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [https://pdbe.org/1rb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1rb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Gcn4 3D Structures\|Gcn4 3D Structures]]
	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]		*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Alber, T~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Holton, J~~]]	+	[[Category: Alber T]]
-	[[Category: ~~Automation]]~~	+	[[Category: Holton J]]
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Leucine zipper~~]]	+

OCA at 09:00, 21 April 2021

2021-04-21T09:00:33Z

←Older revision		Revision as of 09:00, 21 April 2021
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	<StructureSection load='1rb5' size='340' side='right'caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1rb5' size='340' side='right'caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [~~http~~://pdbe.org/1rb5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rb5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rb5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [https://pdbe.org/1rb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1rb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.	+	[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:39, 17 July 2019

2019-07-17T13:39:49Z

←Older revision		Revision as of 13:39, 17 July 2019
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	==ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM==		==ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM==
-	<StructureSection load='1rb5' size='340' side='right' caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='1rb5' size='340' side='right'caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 1rb5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rb5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gnc4 3D Structures\|Gnc4 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alber, T]]		[[Category: Alber, T]]
	[[Category: Holton, J]]		[[Category: Holton, J]]

OCA at 12:00, 12 October 2017

2017-10-12T12:00:51Z

←Older revision		Revision as of 12:00, 12 October 2017
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		+
	==ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM==		==ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM==
	<StructureSection load='1rb5' size='340' side='right' caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='1rb5' size='340' side='right' caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://pdbe.org/1rb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://pdbe.org/1rb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 1rb5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rb5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gcn4\|Gcn4]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Holton, J]]		[[Category: Holton, J]]
	[[Category: Automation]]		[[Category: Automation]]
		+	[[Category: Coiled coil]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]

OCA at 05:49, 11 September 2015

2015-09-11T05:49:44Z

←Older revision		Revision as of 05:49, 11 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://pdbe.org/1rb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rb5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:08, 25 December 2014

2014-12-25T12:08:47Z

←Older revision		Revision as of 12:08, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alber, T.]]	+	[[Category: Alber, T]]
-	[[Category: Holton, J.]]	+	[[Category: Holton, J]]
	[[Category: Automation]]		[[Category: Automation]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]

OCA at 08:30, 8 October 2014

2014-10-08T08:30:43Z

←Older revision		Revision as of 08:30, 8 October 2014
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-	[[~~Image:~~1rb5.~~png~~\|~~left~~\|~~200px~~]]	+	==ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM==
		+	<StructureSection load='1rb5' size='340' side='right' caption='[[1rb5]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RB5 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rb1\|1rb1]], [[1rb4\|1rb4]], [[1rb6\|1rb6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rb5 RCSB], [http://www.ebi.ac.uk/pdbsum/1rb5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Efficient determination of protein crystal structures requires automated x-ray data analysis. Here, we describe the expert system ELVES and its use to determine automatically the structure of a 12-kDa protein. Multiwavelength anomalous diffraction analysis of a selenomethionyl derivative was used to image the Asn-16-Ala variant of the GCN4 leucine zipper. In contrast to the parallel, dimeric coiled coil formed by the WT sequence, the mutant unexpectedly formed an antiparallel trimer. This structural switch reveals how avoidance of core cavities at a single site can select the native fold of a protein. All structure calculations, including indexing, data processing, locating heavy atoms, phasing by multiwavelength anomalous diffraction, model building, and refinement, were completed without human intervention. The results demonstrate the feasibility of automated methods for determining high-resolution, x-ray crystal structures of proteins.

-	~~{{STRUCTURE_1rb5\| PDB=1rb5 \| SCENE= }}~~	+	Automated protein crystal structure determination using ELVES.,Holton J, Alber T Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1537-42. Epub 2004 Jan 29. PMID:14752198<ref>PMID:14752198</ref>

-	~~===ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_14752198}}~~	+	==See Also==
-		+	*[[Gcn4\|Gcn4]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~1rb5~~]] ~~is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA].~~	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:014752198<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alber, T.]]		[[Category: Alber, T.]]
	[[Category: Holton, J.]]		[[Category: Holton, J.]]

OCA: Protected "1rb5" [edit=sysop:move=sysop]

2013-01-04T10:49:41Z

Protected "1rb5" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:49, 4 January 2013

OCA at 10:49, 4 January 2013

2013-01-04T10:49:39Z

←Older revision		Revision as of 10:49, 4 January 2013
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-	{{Seed}}
	[[Image:1rb5.png\|left\|200px]]		[[Image:1rb5.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1rb5\| PDB=1rb5 \| SCENE= }}		{{STRUCTURE_1rb5\| PDB=1rb5 \| SCENE= }}

	===ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM===		===ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM===

-
-	<!--
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	{{ABSTRACT_PUBMED_14752198}}		{{ABSTRACT_PUBMED_14752198}}

	==About this Structure==		==About this Structure==
-	~~1RB5 is a~~ [[~~Single protein~~]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA].	+	[[1rb5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RB5 OCA].

	==Reference==		==Reference==
-	~~Automated protein crystal structure determination using ELVES., Holton J, Alber T, Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1537-42. Epub 2004 Jan 29.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/14752198 14752198]~~	+	<ref group="xtra">PMID:014752198</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Alber, T.]]		[[Category: Alber, T.]]
	[[Category: Holton, J.]]		[[Category: Holton, J.]]
	[[Category: Automation]]		[[Category: Automation]]
-	[[Category: ~~Coiled coil~~]]	+	[[Category: Dna binding protein]]
	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]
-	[[Category: Peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:33:01 2008''

OCA at 18:33, 28 July 2008

2008-07-28T18:33:04Z

←Older revision		Revision as of 18:33, 28 July 2008
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-	[[Image:1rb5.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1rb5.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1rb5\| PDB=1rb5 \| SCENE= }}		{{STRUCTURE_1rb5\| PDB=1rb5 \| SCENE= }}

-	~~'''~~ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM~~'''~~	+	===ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TRIGONAL FORM===


-	~~==Overview==~~	+	<!--
-	~~Efficient determination of protein crystal structures requires automated x-ray data analysis. Here~~, ~~we describe~~ the ~~expert system ELVES and its use~~ to ~~determine automatically~~ the ~~structure of a 12-kDa protein~~. ~~Multiwavelength anomalous diffraction analysis of a selenomethionyl derivative was used to image the Asn-16-Ala variant of the GCN4 leucine zipper~~. ~~In contrast to the parallel~~, ~~dimeric coiled coil formed by~~ the ~~WT sequence, the mutant unexpectedly formed an antiparallel trimer~~. This structural switch reveals how avoidance of core cavities at a single site can select the native fold of a protein. All structure calculations, including indexing, data processing, locating heavy atoms, phasing by multiwavelength anomalous diffraction, model building, and refinement, were completed without human intervention. The results demonstrate the feasibility of automated methods for determining high-~~resolution, x~~-~~ray crystal structures of proteins.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_14752198}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 14752198 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_14752198}}

	==About this Structure==		==About this Structure==
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	[[Category: Leucine zipper]]		[[Category: Leucine zipper]]
	[[Category: Peptide]]		[[Category: Peptide]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:17:38 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:33:01 2008''