1reu - Revision history

OCA at 06:03, 23 August 2023

2023-08-23T06:03:48Z

←Older revision		Revision as of 06:03, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1reu' size='340' side='right'caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1reu' size='340' side='right'caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MPD:(4S)~~-2~~-METHYL-2,4-PENTANEDIOL'>MPD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [https://pdbe.org/1reu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [https://www.ebi.ac.uk/pdbsum/1reu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1reu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [https://pdbe.org/1reu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [https://www.ebi.ac.uk/pdbsum/1reu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1reu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation.	+	[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Keller, S]]	+	[[Category: Keller S]]
-	[[Category: Mueller~~, T D~~]]	+	[[Category: Mueller TD]]
-	[[Category: Nickel, J]]	+	[[Category: Nickel J]]
-	[[Category: Sebald, W]]	+	[[Category: Sebald W]]
-	[[Category: Zhang, J L]]	+	[[Category: Zhang J-L]]
-	~~[[Category: Hormone-growth factor complex]]~~	+
-	~~[[Category: Tgf-beta fold~~]]	+

OCA at 10:12, 15 September 2021

2021-09-15T10:12:29Z

←Older revision		Revision as of 10:12, 15 September 2021
Line 3:		Line 3:
	<StructureSection load='1reu' size='340' side='right'caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1reu' size='340' side='right'caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1REU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [~~http~~://pdbe.org/1reu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1reu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1reu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [https://pdbe.org/1reu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [https://www.ebi.ac.uk/pdbsum/1reu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1reu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation.	+	[[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:27, 4 December 2019

2019-12-04T11:27:37Z

←Older revision		Revision as of 11:27, 4 December 2019
Line 1:		Line 1:

	==Structure of the bone morphogenetic protein 2 mutant L51P==		==Structure of the bone morphogenetic protein 2 mutant L51P==
-	<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='1reu' size='340' side='right'caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Bone morphogenetic protein\|Bone morphogenetic protein]]	+	*[[Bone morphogenetic protein 3D structures\|Bone morphogenetic protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Keller, S]]		[[Category: Keller, S]]
	[[Category: Mueller, T D]]		[[Category: Mueller, T D]]

OCA at 07:52, 28 February 2018

2018-02-28T07:52:24Z

←Older revision		Revision as of 07:52, 28 February 2018
Line 1:		Line 1:
		+
	==Structure of the bone morphogenetic protein 2 mutant L51P==		==Structure of the bone morphogenetic protein 2 mutant L51P==
	<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://pdbe.org/1reu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://pdbe.org/1reu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1reu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1reu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1reu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1reu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1reu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bone morphogenetic protein\|Bone morphogenetic protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:58, 7 February 2016

2016-02-07T08:58:08Z

←Older revision		Revision as of 08:58, 7 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1reu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:51, 9 September 2015

2015-09-09T23:51:32Z

←Older revision		Revision as of 23:51, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://pdbe.org/1reu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1reu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Keller, S]]		[[Category: Keller, S]]
	[[Category: Mueller, T D]]		[[Category: Mueller, T D]]

OCA at 13:51, 24 December 2014

2014-12-24T13:51:12Z

←Older revision		Revision as of 13:51, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>		<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Keller, S.]]	+	[[Category: Keller, S]]
-	[[Category: Mueller, T D.]]	+	[[Category: Mueller, T D]]
-	[[Category: Nickel, J.]]	+	[[Category: Nickel, J]]
-	[[Category: Sebald, W.]]	+	[[Category: Sebald, W]]
-	[[Category: Zhang, J L.]]	+	[[Category: Zhang, J L]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]
	[[Category: Tgf-beta fold]]		[[Category: Tgf-beta fold]]

OCA at 15:33, 29 September 2014

2014-09-29T15:33:08Z

←Older revision		Revision as of 15:33, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1reu.~~png~~\|~~left~~\|200px]]	+	==Structure of the bone morphogenetic protein 2 mutant L51P==
		+	<StructureSection load='1reu' size='340' side='right' caption='[[1reu]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1REU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bmp\|3bmp]], [[1es7\|1es7]], [[1rew\|1rew]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1reu RCSB], [http://www.ebi.ac.uk/pdbsum/1reu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1reu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and organs. Binding epitopes for these extracellular signaling proteins have been defined, but hot spots specifying binding affinity and specificity have so far not been identified. In this study, mutational and structural analyses show that epitopes of BMP-2 and the BRIA receptor form a new type of protein-protein interface. The main chain atoms of Leu 51 and Asp53 of BMP-2 represent a hot spot of binding to BRIA. The BMP-2 variant L51P was deficient in type I receptor binding only, whereas its overall structure and its binding to type II receptors and modulator proteins, such as noggin, were unchanged. Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design.

-	~~{{STRUCTURE_1reu\| PDB=1reu \| SCENE= }}~~	+	Molecular recognition of BMP-2 and BMP receptor IA.,Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD Nat Struct Mol Biol. 2004 May;11(5):481-8. Epub 2004 Apr 4. PMID:15064755<ref>PMID:15064755</ref>

-	~~===Structure~~ of the ~~bone morphogenetic protein 2 mutant L51P===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15064755}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1reu]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015064755<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Keller, S.]]		[[Category: Keller, S.]]

OCA: Protected "1reu" [edit=sysop:move=sysop]

2013-01-04T10:24:15Z

Protected "1reu" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:24, 4 January 2013

OCA at 10:24, 4 January 2013

2013-01-04T10:24:13Z

←Older revision		Revision as of 10:24, 4 January 2013
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-	{{Seed}}
	[[Image:1reu.png\|left\|200px]]		[[Image:1reu.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1reu\| PDB=1reu \| SCENE= }}		{{STRUCTURE_1reu\| PDB=1reu \| SCENE= }}

	===Structure of the bone morphogenetic protein 2 mutant L51P===		===Structure of the bone morphogenetic protein 2 mutant L51P===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15064755}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15064755 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15064755}}		{{ABSTRACT_PUBMED_15064755}}

	==About this Structure==		==About this Structure==
-	~~1REU~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA].	+	[[1reu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REU OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15064755~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015064755</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Keller, S.]]		[[Category: Keller, S.]]
Line 30:		Line 18:
	[[Category: Sebald, W.]]		[[Category: Sebald, W.]]
	[[Category: Zhang, J L.]]		[[Category: Zhang, J L.]]
		+	[[Category: Hormone-growth factor complex]]
	[[Category: Tgf-beta fold]]		[[Category: Tgf-beta fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:44:11 2009''