1rpb - Revision history

OCA at 21:34, 28 June 2023

2023-06-28T21:34:16Z

←Older revision		Revision as of 21:34, 28 June 2023
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	==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==		==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==
-	<StructureSection load='1rpb' size='340' side='right'caption='[[1rpb~~]], [[NMR_Ensembles_of_Models \| 1 NMR models~~]]' scene=''>	+	<StructureSection load='1rpb' size='340' side='right'caption='[[1rpb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycete_Sp9440 Actinomycete Sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[1rpc\|1rpc]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [https://pdbe.org/1rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [https://www.ebi.ac.uk/pdbsum/1rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [https://pdbe.org/1rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [https://www.ebi.ac.uk/pdbsum/1rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/3CP1_STRS9 3CP1_STRS9]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Actinomycetes, strain sp9440~~]]	+	[[Category: Actinomycete Sp9440]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Faucher, D]]	+	[[Category: Faucher D]]
-	[[Category: Frechet, D]]	+	[[Category: Frechet D]]
-	[[Category: Guitton~~, J D~~]]	+	[[Category: Guitton JD]]
-	[[Category: Helynck, G]]	+	[[Category: Helynck G]]
-	[[Category: Herman, F]]	+	[[Category: Herman F]]
-	[[Category: James-Surcouf, E]]	+	[[Category: James-Surcouf E]]
-	[[Category: ~~Ridoux, J P~~]]	+	[[Category: Monegier Du Sorbier B]]
-	[[Category: ~~Sorbier, B Monegier Du~~]]	+	[[Category: Ridoux JP]]
-	[[Category: Vuilhorgne, M]]	+	[[Category: Vuilhorgne M]]
-	~~[[Category: Hiv replication inhibitor]]~~	+
-	~~[[Category: Replication inhibitor~~]]	+

OCA at 07:19, 22 September 2021

2021-09-22T07:19:47Z

←Older revision		Revision as of 07:19, 22 September 2021
Line 3:		Line 3:
	<StructureSection load='1rpb' size='340' side='right'caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1rpb' size='340' side='right'caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rpc\|1rpc]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [~~http~~://pdbe.org/1rpb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rpb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [https://pdbe.org/1rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [https://www.ebi.ac.uk/pdbsum/1rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:49, 11 December 2019

2019-12-11T19:49:16Z

←Older revision		Revision as of 19:49, 11 December 2019
Line 1:		Line 1:

	==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==		==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==
-	<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>	+	<StructureSection load='1rpb' size='340' side='right'caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Actinomycetes, strain sp9440]]		[[Category: Actinomycetes, strain sp9440]]
		+	[[Category: Large Structures]]
	[[Category: Faucher, D]]		[[Category: Faucher, D]]
	[[Category: Frechet, D]]		[[Category: Frechet, D]]

OCA at 07:19, 8 March 2018

2018-03-08T07:19:40Z

←Older revision		Revision as of 07:19, 8 March 2018
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==		==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==
	<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [http://pdbe.org/1rpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [http://www.ebi.ac.uk/pdbsum/1rpb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [http://pdbe.org/1rpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [http://www.ebi.ac.uk/pdbsum/1rpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:30, 9 September 2015

2015-09-09T22:30:59Z

←Older revision		Revision as of 22:30, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>		<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Actinomycete_sp9440 Actinomycete~~ sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycetes,_strain_sp9440 Actinomycetes, strain sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [http://www.ebi.ac.uk/pdbsum/1rpb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [http://pdbe.org/1rpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [http://www.ebi.ac.uk/pdbsum/1rpb PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rpb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Actinomycete~~ sp9440]]	+	[[Category: Actinomycetes, strain sp9440]]
	[[Category: Faucher, D]]		[[Category: Faucher, D]]
	[[Category: Frechet, D]]		[[Category: Frechet, D]]

OCA at 08:25, 24 December 2014

2014-12-24T08:25:52Z

←Older revision		Revision as of 08:25, 24 December 2014
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Actinomycete sp9440]]		[[Category: Actinomycete sp9440]]
-	[[Category: Faucher, D.]]	+	[[Category: Faucher, D]]
-	[[Category: Frechet, D.]]	+	[[Category: Frechet, D]]
-	[[Category: Guitton, J D.]]	+	[[Category: Guitton, J D]]
-	[[Category: Helynck, G.]]	+	[[Category: Helynck, G]]
-	[[Category: Herman, F.]]	+	[[Category: Herman, F]]
-	[[Category: James-Surcouf, E.]]	+	[[Category: James-Surcouf, E]]
-	[[Category: Ridoux, J P.]]	+	[[Category: Ridoux, J P]]
-	[[Category: Sorbier, B Monegier Du.]]	+	[[Category: Sorbier, B Monegier Du]]
-	[[Category: Vuilhorgne, M.]]	+	[[Category: Vuilhorgne, M]]
	[[Category: Hiv replication inhibitor]]		[[Category: Hiv replication inhibitor]]
	[[Category: Replication inhibitor]]		[[Category: Replication inhibitor]]

OCA at 08:34, 8 October 2014

2014-10-08T08:34:58Z

←Older revision		Revision as of 08:34, 8 October 2014
Line 1:		Line 1:
-	[[~~Image:~~1rpb.~~png~~\|~~left~~\|~~200px~~]]	+	==SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS==
		+	<StructureSection load='1rpb' size='340' side='right' caption='[[1rpb]], [[NMR_Ensembles_of_Models \| 1 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RPB FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rpc\|1rpc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rpb RCSB], [http://www.ebi.ac.uk/pdbsum/1rpb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of RP 71955, a new tricyclic 21 amino acid peptide active against human immunodeficiency virus 1, was determined. Its amino acid composition was inferred from the results of fast atom bombardment mass spectrometry, nuclear magnetic resonance, Raman spectroscopy, and amino acid analysis. Its sequence could not be determined classically, using Edman degradation, given the lack of a free terminal NH2. It was deduced from the interpretation of interresidue nuclear Overhauser effects and confirmed by the sequencing of peptides obtained by limited chemical hydrolysis. It was found to be CLGIGSCNDFAGCGYAVVCFW. An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. The three-dimensional structure of RP 71955 was determined from nuclear magnetic resonance derived constraints using distance geometry, restrained molecular dynamics, nuclear Overhauser effect back calculation, and an iterative refinement using a full relaxation matrix approach. Analogies between the structure of RP 71955 and some functional domains of gp41, the transmembrane protein of human immunodeficiency virus 1, suggest hypotheses concerning the mode of action of RP 71955.

-	~~{{STRUCTURE_1rpb\| PDB=1rpb \| SCENE= }}~~	+	Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus.,Frechet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M Biochemistry. 1994 Jan 11;33(1):42-50. PMID:8286361<ref>PMID:8286361</ref>

-	~~===SOLUTION STRUCTURE OF RP 71955~~, ~~A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_8286361}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[1rpb]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].~~	+	</StructureSection>
	[[Category: Actinomycete sp9440]]		[[Category: Actinomycete sp9440]]
	[[Category: Faucher, D.]]		[[Category: Faucher, D.]]

OCA: Protected "1rpb" [edit=sysop:move=sysop]

2013-01-04T10:56:20Z

Protected "1rpb" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 4 January 2013

OCA at 10:56, 4 January 2013

2013-01-04T10:56:18Z

←Older revision		Revision as of 10:56, 4 January 2013
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-	{{Seed}}
	[[Image:1rpb.png\|left\|200px]]		[[Image:1rpb.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1rpb\| PDB=1rpb \| SCENE= }}		{{STRUCTURE_1rpb\| PDB=1rpb \| SCENE= }}

	===SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS===		===SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS===

-
-	<!--
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	{{ABSTRACT_PUBMED_8286361}}		{{ABSTRACT_PUBMED_8286361}}

	==About this Structure==		==About this Structure==
-	~~1RPB is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].	+	[[1rpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].
-		+
-	~~==Reference==~~	+
-	Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus., Frechet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M, Biochemistry. 1994 Jan 11;33(1):42-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8286361 8286361]	+
	[[Category: Actinomycete sp9440]]		[[Category: Actinomycete sp9440]]
-	[[Category: Single protein]]
	[[Category: Faucher, D.]]		[[Category: Faucher, D.]]
	[[Category: Frechet, D.]]		[[Category: Frechet, D.]]
Line 36:		Line 20:
	[[Category: Vuilhorgne, M.]]		[[Category: Vuilhorgne, M.]]
	[[Category: Hiv replication inhibitor]]		[[Category: Hiv replication inhibitor]]
-		+	[[Category: Replication inhibitor]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun Jul 27 13:53:02 2008''~~	+

OCA at 10:53, 27 July 2008

2008-07-27T10:53:04Z

←Older revision		Revision as of 10:53, 27 July 2008
Line 1:		Line 1:
-	[[Image:1rpb.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1rpb.png\|left\|200px]]

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	{{STRUCTURE_1rpb\| PDB=1rpb \| SCENE= }}		{{STRUCTURE_1rpb\| PDB=1rpb \| SCENE= }}

-	~~'''~~SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS~~'''~~	+	===SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS===


-	~~==Overview==~~	+	<!--
-	The ~~structure of RP 71955~~, ~~a new tricyclic 21 amino acid peptide active against human immunodeficiency virus 1~~, ~~was determined. Its amino acid composition was inferred from~~ the results of fast atom bombardment mass spectrometry, nuclear magnetic resonance, Raman spectroscopy, and amino acid analysis. Its sequence could not be determined classically, using Edman degradation, given the lack of a free terminal NH2. It was deduced from the interpretation of interresidue nuclear Overhauser effects and confirmed by the sequencing of peptides obtained by limited chemical hydrolysis. It was found to ~~be CLGIGSCNDFAGCGYAVVCFW. An internal amide bond between~~ the ~~NH2 of C1 and the gamma-COOH of D9 was observed,~~ as ~~well as two disulfide bridges, one between C1 and C13 and one between C7 and C19~~. The three-dimensional structure of RP 71955 was determined from nuclear magnetic resonance derived constraints using distance geometry, restrained molecular dynamics, nuclear Overhauser effect back calculation, and an iterative refinement using a full relaxation matrix approach. ~~Analogies between the structure of RP 71955 and some functional domains of gp41~~, the ~~transmembrane protein of human immunodeficiency virus 1, suggest hypotheses concerning the mode of action of RP 71955~~.	+	The line below this paragraph, {{ABSTRACT_PUBMED_8286361}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8286361 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8286361}}

	==About this Structure==		==About this Structure==
-	1RPB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].	+	1RPB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].

	==Reference==		==Reference==
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	[[Category: Vuilhorgne, M.]]		[[Category: Vuilhorgne, M.]]
	[[Category: Hiv replication inhibitor]]		[[Category: Hiv replication inhibitor]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:45:13 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:53:02 2008''