1rqe - Revision history

OCA at 06:07, 23 August 2023

2023-08-23T06:07:22Z

←Older revision		Revision as of 06:07, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1rqe' size='340' side='right'caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1rqe' size='340' side='right'caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"propionibacterium_shermanii"_van_niel_1928 "propionibacterium~~ shermanii~~" van niel 1928~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1RQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RQE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>~~, ~~<scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1752~~ "~~Propionibacterium shermanii~~" ~~van Niel 1928])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [https://pdbe.org/1rqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [https://www.ebi.ac.uk/pdbsum/1rqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqe ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [~~http~~://pdbe.org/1rqe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rqe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqe ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/5S_PROFR 5S_PROFR]] The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin.	+	[https://www.uniprot.org/uniprot/5S_PROFR 5S_PROFR] The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Propionibacterium shermanii van niel 1928]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Methylmalonyl-CoA carboxytransferase~~]]	+	[[Category: Propionibacterium freudenreichii subsp. shermanii]]
-	[[Category: Antony, L]]	+	[[Category: Antony L]]
-	[[Category: Carey~~, P R~~]]	+	[[Category: Carey PR]]
-	[[Category: Hall~~, P R~~]]	+	[[Category: Hall PR]]
-	[[Category: Pusztai-Carey, M]]	+	[[Category: Pusztai-Carey M]]
-	[[Category: Yee~~, V C~~]]	+	[[Category: Yee VC]]
-	[[Category: Zheng, R]]	+	[[Category: Zheng R]]
-	~~[[Category: Carbamylated lysine]]~~	+
-	~~[[Category: Cobalt]]~~	+
-	~~[[Category: Oxaloacetate]]~~	+
-	~~[[Category: Tim-barrel]]~~	+
-	~~[[Category: Transcarboxylase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:31, 16 December 2020

2020-12-16T13:31:54Z

←Older revision		Revision as of 13:31, 16 December 2020
Line 1:		Line 1:

	==Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate==		==Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate==
-	<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1rqe' size='340' side='right'caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"propionibacterium_shermanii"_van_niel_1928 "propionibacterium shermanii" van niel 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"propionibacterium_shermanii"_van_niel_1928 "propionibacterium shermanii" van niel 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1RQE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://pdbe.org/1rqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://pdbe.org/1rqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Propionibacterium shermanii van niel 1928]]		[[Category: Propionibacterium shermanii van niel 1928]]
		+	[[Category: Large Structures]]
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
	[[Category: Antony, L]]		[[Category: Antony, L]]

OCA at 06:52, 8 March 2018

2018-03-08T06:52:10Z

←Older revision		Revision as of 06:52, 8 March 2018
Line 1:		Line 1:
		+
	==Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate==		==Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate==
	<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://pdbe.org/1rqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://pdbe.org/1rqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rqe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqe_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:31, 9 February 2016

2016-02-09T09:31:15Z

←Older revision		Revision as of 09:31, 9 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rqe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:54, 10 September 2015

2015-09-10T20:54:36Z

←Older revision		Revision as of 20:54, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp.~~ shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"propionibacterium_shermanii"_van_niel_1928 "propionibacterium shermanii" van niel 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RQE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium ~~freudenreichii subsp.~~ shermanii])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 "Propionibacterium shermanii" van Niel 1928])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://pdbe.org/1rqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rqe" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Propionibacterium shermanii van niel 1928]]
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
-	[[Category: Propionibacterium freudenreichii subsp. shermanii]]
	[[Category: Antony, L]]		[[Category: Antony, L]]
	[[Category: Carey, P R]]		[[Category: Carey, P R]]

OCA at 07:00, 6 January 2015

2015-01-06T07:00:27Z

←Older revision		Revision as of 07:00, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RQE FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RQE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/5S_PROFR 5S_PROFR]] The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]
-	[[Category: Antony, L.]]	+	[[Category: Antony, L]]
-	[[Category: Carey, P R.]]	+	[[Category: Carey, P R]]
-	[[Category: Hall, P R.]]	+	[[Category: Hall, P R]]
-	[[Category: Pusztai-Carey, M.]]	+	[[Category: Pusztai-Carey, M]]
-	[[Category: Yee, V C.]]	+	[[Category: Yee, V C]]
-	[[Category: Zheng, R.]]	+	[[Category: Zheng, R]]
	[[Category: Carbamylated lysine]]		[[Category: Carbamylated lysine]]
	[[Category: Cobalt]]		[[Category: Cobalt]]

OCA at 11:11, 3 October 2014

2014-10-03T11:11:00Z

←Older revision		Revision as of 11:11, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1rqe\| PDB~~=1rqe \| ~~SCENE~~= }}	+	==Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate==
-	===Propionibacterium shermanii ~~transcarboxylase~~ 5S ~~subunit bound~~ to ~~oxaloacetate~~===	+	<StructureSection load='1rqe' size='340' side='right' caption='[[1rqe]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_15329673}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_freudenreichii_subsp._shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RQE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1rqb\|1rqb]], [[1rqh\|1rqh]], [[1rr2\|1rr2]], [[1s3h\|1s3h]], [[1s27\|1s27]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1752 Propionibacterium freudenreichii subsp. shermanii])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_carboxytransferase Methylmalonyl-CoA carboxytransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.1 2.1.3.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rqe RCSB], [http://www.ebi.ac.uk/pdbsum/1rqe PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rqe_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transcarboxylase is a 1.2 million Dalton (Da) multienzyme complex from Propionibacterium shermanii that couples two carboxylation reactions, transferring CO(2)(-) from methylmalonyl-CoA to pyruvate to yield propionyl-CoA and oxaloacetate. Crystal structures of the 5S metalloenzyme subunit, which catalyzes the second carboxylation reaction, have been solved in free form and bound to its substrate pyruvate, product oxaloacetate, or inhibitor 2-ketobutyrate. The structure reveals a dimer of beta(8)alpha(8) barrels with an active site cobalt ion coordinated by a carbamylated lysine, except in the oxaloacetate complex in which the product's carboxylate group serves as a ligand instead. 5S and human pyruvate carboxylase (PC), an enzyme crucial to gluconeogenesis, catalyze similar reactions. A 5S-based homology model of the PC carboxyltransferase domain indicates a conserved mechanism and explains the molecular basis of mutations in lactic acidemia. PC disease mutations reproduced in 5S result in a similar decrease in carboxyltransferase activity and crystal structures with altered active sites.

-	~~==Function==~~	+	Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.,Hall PR, Zheng R, Antony L, Pusztai-Carey M, Carey PR, Yee VC EMBO J. 2004 Sep 15;23(18):3621-31. Epub 2004 Aug 26. PMID:15329673<ref>PMID:15329673</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/5S_PROFR 5S_PROFR]] The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1~~.~~3S subunit to pyruvate to form oxaloacetate and 1.3S biotin~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[1rqe]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Propionibacterium_freudenreichii_subsp~~.~~_shermanii Propionibacterium freudenreichii subsp. shermanii]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1RQE OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:015329673</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]

OCA at 10:58, 16 April 2014

2014-04-16T10:58:54Z

←Older revision		Revision as of 10:58, 16 April 2014
Line 1:		Line 1:
-	[[Image:1rqe.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_1rqe", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1rqe\| PDB=1rqe \| SCENE= }}		{{STRUCTURE_1rqe\| PDB=1rqe \| SCENE= }}
-
	===Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate===		===Propionibacterium shermanii transcarboxylase 5S subunit bound to oxaloacetate===
		+	{{ABSTRACT_PUBMED_15329673}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/5S_PROFR 5S_PROFR]] The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_15329673}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 15329673 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_15329673}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:015329673</ref><~~ref~~ group="xtra"~~>PMID:014993680<~~/~~ref~~><references ~~group="xtra"~~/>	+	<ref group="xtra">PMID:015329673</ref><references group="xtra"/><references/>
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]

OCA at 10:20, 16 November 2011

2011-11-16T10:20:58Z

←Older revision		Revision as of 10:20, 16 November 2011
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15329673~~</ref><ref group="xtra">PMID:~~14993680~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015329673</ref><ref group="xtra">PMID:014993680</ref><references group="xtra"/>
	[[Category: Methylmalonyl-CoA carboxytransferase]]		[[Category: Methylmalonyl-CoA carboxytransferase]]
	[[Category: Propionibacterium freudenreichii subsp. shermanii]]		[[Category: Propionibacterium freudenreichii subsp. shermanii]]

OCA: Protected "1rqe" [edit=sysop:move=sysop]

2011-03-14T21:55:31Z

Protected "1rqe" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:55, 14 March 2011