1rvx - Revision history

OCA at 06:08, 23 August 2023

2023-08-23T06:08:51Z

←Older revision		Revision as of 06:08, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1rvx' size='340' side='right'caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1rvx' size='340' side='right'caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~puerto_rico~~/8/34(~~h1n1~~)) Influenza a virus (a/~~puerto rico~~/8/34(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [https://pdbe.org/1rvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [https://www.ebi.ac.uk/pdbsum/1rvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [https://pdbe.org/1rvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [https://www.ebi.ac.uk/pdbsum/1rvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q82766_9INFA Q82766_9INFA]~~] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization ~~of about two third of the virus particles~~ through clathrin-dependent endocytosis ~~and about one third~~ through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore ~~(By similarity)~~.[~~RuleBase:RU003324][SAAS~~:~~SAAS013827_004_327643~~]	+	[https://www.uniprot.org/uniprot/HEMA_I34A1 HEMA_I34A1] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Daniels~~, R S~~]]	+	[[Category: Daniels RS]]
-	[[Category: Elliot, A]]	+	[[Category: Elliot A]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Ha, Y]]	+	[[Category: Ha Y]]
-	[[Category: Haire~~, L F~~]]	+	[[Category: Haire LF]]
-	[[Category: Russell~~, R J~~]]	+	[[Category: Russell RJ]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Steinhauer~~, D A~~]]	+	[[Category: Steinhauer DA]]
-	[[Category: Stevens~~, D J~~]]	+	[[Category: Stevens DJ]]
-	[[Category: Vasisht, N]]	+	[[Category: Vasisht N]]
-	[[Category: Wiley~~, D C~~]]	+	[[Category: Wiley DC]]
-	[[Category: Xiao, B]]	+	[[Category: Xiao B]]
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Influenza a virus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:23, 22 September 2021

2021-09-22T07:23:09Z

←Older revision		Revision as of 07:23, 22 September 2021
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	<StructureSection load='1rvx' size='340' side='right'caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1rvx' size='340' side='right'caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RVX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [~~http~~://pdbe.org/1rvx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rvx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvx ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [https://pdbe.org/1rvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [https://www.ebi.ac.uk/pdbsum/1rvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q82766_9INFA Q82766_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013827_004_327643]	+	[[https://www.uniprot.org/uniprot/Q82766_9INFA Q82766_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013827_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:41, 11 December 2019

2019-12-11T19:41:34Z

←Older revision		Revision as of 19:41, 11 December 2019
Line 1:		Line 1:

	==1934 H1 Hemagglutinin in complex with LSTA==		==1934 H1 Hemagglutinin in complex with LSTA==
-	<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1rvx' size='340' side='right'caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 07:11, 8 March 2018

2018-03-08T07:11:48Z

←Older revision		Revision as of 07:11, 8 March 2018
Line 1:		Line 1:
		+
	==1934 H1 Hemagglutinin in complex with LSTA==		==1934 H1 Hemagglutinin in complex with LSTA==
	<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~I34a1 I34a1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://pdbe.org/1rvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://pdbe.org/1rvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rvx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: I34a1]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 09:30, 11 September 2015

2015-09-11T09:30:31Z

←Older revision		Revision as of 09:30, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/I34a1 I34a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://pdbe.org/1rvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rvx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: I34a1]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 14:31, 25 December 2014

2014-12-25T14:31:47Z

←Older revision		Revision as of 14:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q82766_9INFA Q82766_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013827_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Daniels, R S.]]	+	[[Category: Daniels, R S]]
-	[[Category: Elliot, A.]]	+	[[Category: Elliot, A]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Ha, Y.]]	+	[[Category: Ha, Y]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Russell, R J.]]	+	[[Category: Russell, R J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Steinhauer, D A.]]	+	[[Category: Steinhauer, D A]]
-	[[Category: Stevens, D J.]]	+	[[Category: Stevens, D J]]
-	[[Category: Vasisht, N.]]	+	[[Category: Vasisht, N]]
-	[[Category: Wiley, D C.]]	+	[[Category: Wiley, D C]]
-	[[Category: Xiao, B.]]	+	[[Category: Xiao, B]]
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 17:08, 29 September 2014

2014-09-29T17:08:41Z

←Older revision		Revision as of 17:08, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1rvx\| PDB=1rvx \| SCENE= }}~~	+	==1934 H1 Hemagglutinin in complex with LSTA==
-	===1934 H1 Hemagglutinin in complex with LSTA===	+	<StructureSection load='1rvx' size='340' side='right' caption='[[1rvx]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_14764886}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvz\|1rvz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvx RCSB], [http://www.ebi.ac.uk/pdbsum/1rvx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

-	~~==About this Structure==~~	+	The structure and receptor binding properties of the 1918 influenza hemagglutinin.,Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886<ref>PMID:14764886</ref>
-	~~[[1rvx]] is a 12 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_a_virus_~~(~~a/puerto_rico/8/1934(h1n1~~)~~) Influenza a virus (a/puerto rico/8/1934(h1n1))]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1RVX OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014764886<~~/~~ref~~><~~ref group="xtra">PMID:015246268</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Daniels, R S.]]		[[Category: Daniels, R S.]]
	[[Category: Elliot, A.]]		[[Category: Elliot, A.]]

OCA at 10:38, 11 March 2013

2013-03-11T10:38:23Z

←Older revision		Revision as of 10:38, 11 March 2013
Line 1:		Line 1:
-	[[Image:1rvx.png\|left\|200px]]
-
	{{STRUCTURE_1rvx\| PDB=1rvx \| SCENE= }}		{{STRUCTURE_1rvx\| PDB=1rvx \| SCENE= }}
-
	===1934 H1 Hemagglutinin in complex with LSTA===		===1934 H1 Hemagglutinin in complex with LSTA===
-
	{{ABSTRACT_PUBMED_14764886}}		{{ABSTRACT_PUBMED_14764886}}

OCA at 17:51, 20 October 2012

2012-10-20T17:51:20Z

←Older revision		Revision as of 17:51, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1rvx]] is a 12 chain structure ~~of [[Hemagglutinin]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA].	+	[[1rvx]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVX OCA].

	==See Also==		==See Also==

OCA: Protected "1rvx" [edit=sysop:move=sysop]

2012-07-27T02:13:05Z

Protected "1rvx" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:13, 27 July 2012