1rvz - Revision history

OCA at 06:08, 23 August 2023

2023-08-23T06:08:56Z

←Older revision		Revision as of 06:08, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1rvz' size='340' side='right'caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1rvz' size='340' side='right'caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~puerto_rico~~/8/34(~~h1n1~~)) Influenza a virus (a/~~puerto rico~~/8/34(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~, ~~<scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900046:6-sialyl-N-acetyllactosamine'>PRD_900046</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<~~tr id~~='~~related~~'><~~td class="sblockLbl"~~><~~b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [https://pdbe.org/1rvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [https://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [~~http~~://pdbe.org/1rvz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~Q82766_9INFA Q82766_9INFA]~~] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization ~~of about two third of the virus particles~~ through clathrin-dependent endocytosis ~~and about one third~~ through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore ~~(By similarity)~~.[~~RuleBase:RU003324][SAAS~~:~~SAAS013827_004_327643~~]	+	[https://www.uniprot.org/uniprot/HEMA_I34A1 HEMA_I34A1] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Daniels~~, R S~~]]	+	[[Category: Daniels RS]]
-	[[Category: Elliot, A]]	+	[[Category: Elliot A]]
-	[[Category: Gamblin~~, S J~~]]	+	[[Category: Gamblin SJ]]
-	[[Category: Ha, Y]]	+	[[Category: Ha Y]]
-	[[Category: Haire~~, L F~~]]	+	[[Category: Haire LF]]
-	[[Category: Russell~~, R J~~]]	+	[[Category: Russell RJ]]
-	[[Category: Skehel~~, J J~~]]	+	[[Category: Skehel JJ]]
-	[[Category: Steinhauer~~, D A~~]]	+	[[Category: Steinhauer DA]]
-	[[Category: Stevens~~, D J~~]]	+	[[Category: Stevens DJ]]
-	[[Category: Vasisht, N]]	+	[[Category: Vasisht N]]
-	[[Category: Wiley~~, D C~~]]	+	[[Category: Wiley DC]]
-	[[Category: Xiao, B]]	+	[[Category: Xiao B]]
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Influenza a virus]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:39, 16 September 2020

2020-09-16T10:39:20Z

←Older revision		Revision as of 10:39, 16 September 2020
Line 1:		Line 1:

	==1934 H1 Hemagglutinin in complex with LSTC==		==1934 H1 Hemagglutinin in complex with LSTC==
-	<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='1rvz' size='340' side='right'caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 32:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 08:03, 12 December 2018

2018-12-12T08:03:40Z

←Older revision		Revision as of 08:03, 12 December 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>
Line 15:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:24, 10 March 2017

2017-03-10T01:24:49Z

←Older revision		Revision as of 01:24, 10 March 2017
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1rvz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rvz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:50, 1 February 2017

2017-02-01T10:50:51Z

←Older revision		Revision as of 10:50, 1 February 2017
Line 1:		Line 1:
		+
	==1934 H1 Hemagglutinin in complex with LSTC==		==1934 H1 Hemagglutinin in complex with LSTC==
	<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~I34a1 I34a1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1rvz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 1rvz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1rvz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: I34a1]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 13:35, 9 February 2016

2016-02-09T13:35:05Z

←Older revision		Revision as of 13:35, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rvz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:44, 10 September 2015

2015-09-10T22:44:03Z

←Older revision		Revision as of 22:44, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/I34a1 I34a1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://pdbe.org/1rvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1rvz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: I34a1]]
	[[Category: Daniels, R S]]		[[Category: Daniels, R S]]
	[[Category: Elliot, A]]		[[Category: Elliot, A]]

OCA at 07:07, 25 December 2014

2014-12-25T07:07:43Z

←Older revision		Revision as of 07:07, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q82766_9INFA Q82766_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013827_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Daniels, R S.]]	+	[[Category: Daniels, R S]]
-	[[Category: Elliot, A.]]	+	[[Category: Elliot, A]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
	[[Category: Ha, Y]]		[[Category: Ha, Y]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Russell, R J.]]	+	[[Category: Russell, R J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Steinhauer, D A.]]	+	[[Category: Steinhauer, D A]]
-	[[Category: Stevens, D J.]]	+	[[Category: Stevens, D J]]
-	[[Category: Vasisht, N.]]	+	[[Category: Vasisht, N]]
-	[[Category: Wiley, D C.]]	+	[[Category: Wiley, D C]]
-	[[Category: Xiao, B.]]	+	[[Category: Xiao, B]]
	[[Category: Hemagglutinin]]		[[Category: Hemagglutinin]]
	[[Category: Influenza a virus]]		[[Category: Influenza a virus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 14:08, 29 September 2014

2014-09-29T14:08:52Z

←Older revision		Revision as of 14:08, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1rvz\| PDB=1rvz \| SCENE= }}~~	+	==1934 H1 Hemagglutinin in complex with LSTC==
-	===1934 H1 Hemagglutinin in complex with LSTC===	+	<StructureSection load='1rvz' size='340' side='right' caption='[[1rvz]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_14764886}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1rvz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/1934(h1n1)) Influenza a virus (a/puerto rico/8/1934(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RVZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ru7\|1ru7]], [[1ruy\|1ruy]], [[1ruz\|1ruz]], [[1rv0\|1rv0]], [[1rvt\|1rvt]], [[1rvx\|1rvx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1rvz RCSB], [http://www.ebi.ac.uk/pdbsum/1rvz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rvz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

-	~~==About this Structure==~~	+	The structure and receptor binding properties of the 1918 influenza hemagglutinin.,Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886<ref>PMID:14764886</ref>
-	~~[[1rvz]] is a 12 chain~~ structure ~~with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_a_virus_~~(~~a/puerto_rico/8/1934(h1n1~~)~~) Influenza a virus (a/puerto rico/8/1934(h1n1))]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1RVZ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:014764886<~~/~~ref~~><~~ref group="xtra">PMID:015246268</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Daniels, R S.]]		[[Category: Daniels, R S.]]
	[[Category: Elliot, A.]]		[[Category: Elliot, A.]]

OCA at 09:24, 11 March 2013

2013-03-11T09:24:19Z

←Older revision		Revision as of 09:24, 11 March 2013
Line 1:		Line 1:
-	[[Image:1rvz.png\|left\|200px]]
-
	{{STRUCTURE_1rvz\| PDB=1rvz \| SCENE= }}		{{STRUCTURE_1rvz\| PDB=1rvz \| SCENE= }}
-
	===1934 H1 Hemagglutinin in complex with LSTC===		===1934 H1 Hemagglutinin in complex with LSTC===
-
	{{ABSTRACT_PUBMED_14764886}}		{{ABSTRACT_PUBMED_14764886}}