1s4v - Revision history

OCA at 06:12, 23 August 2023

2023-08-23T06:12:44Z

←Older revision		Revision as of 06:12, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [https://pdbe.org/1s4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [https://www.ebi.ac.uk/pdbsum/1s4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [https://pdbe.org/1s4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [https://www.ebi.ac.uk/pdbsum/1s4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4v ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CYSEP_RICCO CYSEP_RICCO] Involved in programmed cell death. Shows a pronounced preference for hydrophobic residues in the P2 position and no obvious preference in the P1 position of the cleavage site. Accepts proline at the P1 and P1' positions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
-	[[Category: Gietl, C]]	+	[[Category: Gietl C]]
-	[[Category: Helm, M]]	+	[[Category: Helm M]]
-	[[Category: Huber, R]]	+	[[Category: Huber R]]
-	[[Category: Lottspeich, F]]	+	[[Category: Lottspeich F]]
-	[[Category: Simpson~~, D J~~]]	+	[[Category: Simpson DJ]]
-	[[Category: Than~~, M E]]~~	+	[[Category: Than ME]]
-	~~[[Category: Endosperm]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Kdel er retention signal]]~~	+
-	~~[[Category: Ricinosome]]~~	+
-	~~[[Category: Seed germination]]~~	+
-	~~[[Category: Senescence~~]]	+

OCA at 07:26, 22 September 2021

2021-09-22T07:26:52Z

←Older revision		Revision as of 07:26, 22 September 2021
Line 3:		Line 3:
	<StructureSection load='1s4v' size='340' side='right'caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1s4v' size='340' side='right'caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1S4V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [~~http~~://pdbe.org/1s4v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1s4v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [https://pdbe.org/1s4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [https://www.ebi.ac.uk/pdbsum/1s4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:28, 11 December 2019

2019-12-11T19:28:09Z

←Older revision		Revision as of 19:28, 11 December 2019
Line 1:		Line 1:

	==The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm==		==The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm==
-	<StructureSection load='1s4v' size='340' side='right' caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1s4v' size='340' side='right'caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4V FirstGlance]. <br>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
	[[Category: Gietl, C]]		[[Category: Gietl, C]]

OCA at 06:59, 8 March 2018

2018-03-08T06:59:18Z

←Older revision		Revision as of 06:59, 8 March 2018
Line 1:		Line 1:
		+
	==The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm==		==The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm==
	<StructureSection load='1s4v' size='340' side='right' caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1s4v' size='340' side='right' caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://pdbe.org/1s4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://pdbe.org/1s4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4v ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:40, 9 February 2016

2016-02-09T04:40:51Z

←Older revision		Revision as of 04:40, 9 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s4v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:43, 10 September 2015

2015-09-10T18:43:18Z

←Older revision		Revision as of 18:43, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://pdbe.org/1s4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1s4v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:08, 6 January 2015

2015-01-06T08:08:20Z

←Older revision		Revision as of 08:08, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4V FirstGlance]. <br>		<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
-	[[Category: Gietl, C.]]	+	[[Category: Gietl, C]]
-	[[Category: Helm, M.]]	+	[[Category: Helm, M]]
-	[[Category: Huber, R.]]	+	[[Category: Huber, R]]
-	[[Category: Lottspeich, F.]]	+	[[Category: Lottspeich, F]]
-	[[Category: Simpson, D J.]]	+	[[Category: Simpson, D J]]
-	[[Category: Than, M E.]]	+	[[Category: Than, M E]]
	[[Category: Endosperm]]		[[Category: Endosperm]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 15:35, 29 September 2014

2014-09-29T15:35:52Z

←Older revision		Revision as of 15:35, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1s4v.~~png~~\|~~left~~\|200px]]	+	==The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm==
		+	<StructureSection load='1s4v' size='340' side='right' caption='[[1s4v]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S4V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s4v RCSB], [http://www.ebi.ac.uk/pdbsum/1s4v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the senescing endosperm of germinating castor bean (Ricinus communis) a special organelle (the ricinosome) releases a papain-type cysteine endopeptidase (CysEP) during the final stages of cellular disintegration. Protein cleavage sites for the Ricinus CysEP were determined with fluorogenic peptides (Abz-Xaa-Arg-/-Gln-Gln-Tyr(NO2)-Asp). The highest kcat/Km values were obtained with neutral amino acid residues with large aliphatic and non-polar (Leu, Val, Ile, Met) or aromatic (Phe, Tyr, Trp) side-chains. A second series (Abz-Leu-Xaa-/Gln-Pro-Tyr(NO2)-Asp) was evaluated. Based on these results, the covalent binding inhibitor H-D-Val-Leu-Lys-chloromethylketone (CMK) was chosen as substrate analogue for replacement in the catalytic site. Unusually, CysEP cleaved beta-casein N and C-terminal to the amino acid proline. CysEP was crystallized, its structure was solved by molecular replacement at 2.0 A resolution and refined to a R-factor of 18.1% (Rfree=22.6%). The polypeptide chain folds as in papain into two domains divided by the active site cleft, an elongated surface depression harboring the active site. The non-primed specificity subsites of the proteinase are clearly defined by the H-D-Val-Leu-Lys-CMK-inhibitor covalently bound to the active site. The absence of the occluding loop, which blocks the active site of exopeptidases at the C-terminal side of the scissile bond, identifies CysEP as an endopeptidase. The more open pocket of the Ricinus CysEP correlates with the extended variety of substrate amino acid residues accommodated by this enzyme, including even proline at the P1 and P1' positions. This may allow the enzyme to attack a greater variety of proteins during programmed cell death.

-	~~{{STRUCTURE_1s4v\| PDB=1s4v \| SCENE= }}~~	+	The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm.,Than ME, Helm M, Simpson DJ, Lottspeich F, Huber R, Gietl C J Mol Biol. 2004 Mar 5;336(5):1103-16. PMID:15037072<ref>PMID:15037072</ref>

-	~~===The 2.0 A crystal structure~~ of the ~~KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15037072}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1s4v]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ricinus_communis Ricinus communis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015037072<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
	[[Category: Gietl, C.]]		[[Category: Gietl, C.]]

OCA: Protected "1s4v" [edit=sysop:move=sysop]

2013-01-04T10:29:52Z

Protected "1s4v" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:29, 4 January 2013

OCA at 10:29, 4 January 2013

2013-01-04T10:29:49Z

←Older revision		Revision as of 10:29, 4 January 2013
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	[[Image:1s4v.png\|left\|200px]]		[[Image:1s4v.png\|left\|200px]]

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	{{STRUCTURE_1s4v\| PDB=1s4v \| SCENE= }}		{{STRUCTURE_1s4v\| PDB=1s4v \| SCENE= }}

	===The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm===		===The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm===

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	{{ABSTRACT_PUBMED_15037072}}		{{ABSTRACT_PUBMED_15037072}}

	==About this Structure==		==About this Structure==
-	~~1S4V~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA].	+	[[1s4v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4V OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15037072~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015037072</ref><references group="xtra"/>
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
	[[Category: Gietl, C.]]		[[Category: Gietl, C.]]
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	[[Category: Than, M E.]]		[[Category: Than, M E.]]
	[[Category: Endosperm]]		[[Category: Endosperm]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Kdel er retention signal]]		[[Category: Kdel er retention signal]]
	[[Category: Ricinosome]]		[[Category: Ricinosome]]
	[[Category: Seed germination]]		[[Category: Seed germination]]
	[[Category: Senescence]]		[[Category: Senescence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:33:05 2009''