1shi - Revision history

OCA at 08:32, 1 May 2024

2024-05-01T08:32:01Z

←Older revision		Revision as of 08:32, 1 May 2024
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	==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==		==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==
-	<StructureSection load='1shi' size='340' side='right'caption='[[1shi~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1shi' size='340' side='right'caption='[[1shi]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Stihl Stihl~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [https://pdbe.org/1shi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [https://www.ebi.ac.uk/pdbsum/1shi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [https://pdbe.org/1shi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [https://www.ebi.ac.uk/pdbsum/1shi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~TXA1_STOHE TXA1_STOHE]~~] Binds specifically to ~~the~~ sodium ~~channel~~ (Nav), thereby delaying ~~its~~ inactivation during signal transduction. ~~Selectively~~ toxic to ~~crustaceans~~.<ref>PMID:~~7913833~~</ref>	+	[https://www.uniprot.org/uniprot/NA21_STIHL NA21_STIHL] Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (By similarity). Is highly toxic to crabs (by intrahemocoelic injection) (PubMed:2568126, PubMed:22015268), but without effect upon mice (by intraperitoneal injection) (PubMed:2568126).<ref>PMID:22015268</ref> <ref>PMID:2568126</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shi ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A high resolution structure in solution has been determined for the polypeptide neurotoxin I, from the sea anemone Stichodactyla helianthus, using NMR data, distance geometry calculations, and refinement by back-calculation of two-dimensional nuclear Overhauser enhancement (NOE) spectra. A set of 913 distance constraints derived from NOEs was used, together with a large set of lower distance bounds based on the absence of NOEs in the spectrum. Eight published structures for neurotoxin I were refined independently to give structures which agree better with the experimental data, as reflected in reduced R factors calculated over well resolved cross-peaks of the two-dimensional NOE spectra and a lower total volume of peaks in back-calculated spectra that are absent from experimental spectra. The refined structures are also more precisely defined, with mean pairwise root mean square differences over backbone heavy atoms of 0.62 A for well defined residues and 1.14 A for all residues, compared with previous values of 1.09 and 2.41 A, respectively. The consensus constraint set from the 8 refined structures was also used to generate 12 new structures, with corresponding root mean square differences of 0.76 and 1.26 A. In all 20 structures the loop linking the first and second strands of the beta-sheet is considerably better defined than before. A type I beta-turn encompassing the functionally important residues Asp6, Asp7, and Glu8 is evident in the refined structures.
-
-	Refined structure in solution of the sea anemone neurotoxin ShI.,Wilcox GR, Fogh RH, Norton RS J Biol Chem. 1993 Nov 25;268(33):24707-19. PMID:7901218<ref>PMID:7901218</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1shi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Stihl~~]]	+	[[Category: Stichodactyla helianthus]]
-	[[Category: Dyke~~, T R~~]]	+	[[Category: Dyke TR]]
-	[[Category: Norton~~, R S~~]]	+	[[Category: Norton RS]]
-	[[Category: Pallaghy~~, P K]]~~	+	[[Category: Pallaghy PK]]
-	~~[[Category: Neurotoxin~~]]	+

OCA at 07:31, 22 September 2021

2021-09-22T07:31:38Z

←Older revision		Revision as of 07:31, 22 September 2021
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	<StructureSection load='1shi' size='340' side='right'caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1shi' size='340' side='right'caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1SHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [~~http~~://pdbe.org/1shi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1shi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [https://pdbe.org/1shi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [https://www.ebi.ac.uk/pdbsum/1shi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TXA1_STOHE TXA1_STOHE]] Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Selectively toxic to crustaceans.<ref>PMID:7913833</ref>	+	[[https://www.uniprot.org/uniprot/TXA1_STOHE TXA1_STOHE]] Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Selectively toxic to crustaceans.<ref>PMID:7913833</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:16, 4 December 2019

2019-12-04T11:16:40Z

←Older revision		Revision as of 11:16, 4 December 2019
Line 1:		Line 1:

	==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==		==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==
-	<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1shi' size='340' side='right'caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Stihl]]		[[Category: Stihl]]
	[[Category: Dyke, T R]]		[[Category: Dyke, T R]]

OCA at 06:57, 29 November 2017

2017-11-29T06:57:06Z

←Older revision		Revision as of 06:57, 29 November 2017
Line 1:		Line 1:
		+
	==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==		==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==
	<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Carribean_sea_anemone Carribean sea anemone~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://pdbe.org/1shi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://pdbe.org/1shi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1shi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carribean sea anemone~~]]	+	[[Category: Stihl]]
	[[Category: Dyke, T R]]		[[Category: Dyke, T R]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Pallaghy, P K]]		[[Category: Pallaghy, P K]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 09:06, 11 September 2015

2015-09-11T09:06:12Z

←Older revision		Revision as of 09:06, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Stichodactyla_helianthus Stichodactyla helianthus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Carribean_sea_anemone Carribean sea anemone]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://pdbe.org/1shi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1shi" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Stichodactyla helianthus~~]]	+	[[Category: Carribean sea anemone]]
	[[Category: Dyke, T R]]		[[Category: Dyke, T R]]
	[[Category: Norton, R S]]		[[Category: Norton, R S]]
	[[Category: Pallaghy, P K]]		[[Category: Pallaghy, P K]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 14:15, 25 December 2014

2014-12-25T14:15:24Z

←Older revision		Revision as of 14:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>		<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TXA1_STOHE TXA1_STOHE]] Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Selectively toxic to crustaceans.<ref>PMID:7913833</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
-	[[Category: Dyke, T R.]]	+	[[Category: Dyke, T R]]
-	[[Category: Norton, R S.]]	+	[[Category: Norton, R S]]
-	[[Category: Pallaghy, P K.]]	+	[[Category: Pallaghy, P K]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

OCA at 16:51, 29 September 2014

2014-09-29T16:51:43Z

←Older revision		Revision as of 16:51, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1shi.~~png\|left~~\|200px]]	+	==REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI==
		+	<StructureSection load='1shi' size='340' side='right' caption='[[1shi]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SHI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1shi RCSB], [http://www.ebi.ac.uk/pdbsum/1shi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A high resolution structure in solution has been determined for the polypeptide neurotoxin I, from the sea anemone Stichodactyla helianthus, using NMR data, distance geometry calculations, and refinement by back-calculation of two-dimensional nuclear Overhauser enhancement (NOE) spectra. A set of 913 distance constraints derived from NOEs was used, together with a large set of lower distance bounds based on the absence of NOEs in the spectrum. Eight published structures for neurotoxin I were refined independently to give structures which agree better with the experimental data, as reflected in reduced R factors calculated over well resolved cross-peaks of the two-dimensional NOE spectra and a lower total volume of peaks in back-calculated spectra that are absent from experimental spectra. The refined structures are also more precisely defined, with mean pairwise root mean square differences over backbone heavy atoms of 0.62 A for well defined residues and 1.14 A for all residues, compared with previous values of 1.09 and 2.41 A, respectively. The consensus constraint set from the 8 refined structures was also used to generate 12 new structures, with corresponding root mean square differences of 0.76 and 1.26 A. In all 20 structures the loop linking the first and second strands of the beta-sheet is considerably better defined than before. A type I beta-turn encompassing the functionally important residues Asp6, Asp7, and Glu8 is evident in the refined structures.

-	~~{{STRUCTURE_1shi\| PDB=1shi \| SCENE= }}~~	+	Refined structure in solution of the sea anemone neurotoxin ShI.,Wilcox GR, Fogh RH, Norton RS J Biol Chem. 1993 Nov 25;268(33):24707-19. PMID:7901218<ref>PMID:7901218</ref>

-	~~===REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_7901218}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1shi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:007901218<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
	[[Category: Dyke, T R.]]		[[Category: Dyke, T R.]]

OCA: Protected "1shi" [edit=sysop:move=sysop]

2013-01-04T10:09:56Z

Protected "1shi" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:09, 4 January 2013

OCA at 10:09, 4 January 2013

2013-01-04T10:09:53Z

←Older revision		Revision as of 10:09, 4 January 2013
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-	{{Seed}}
	[[Image:1shi.png\|left\|200px]]		[[Image:1shi.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1shi\| PDB=1shi \| SCENE= }}		{{STRUCTURE_1shi\| PDB=1shi \| SCENE= }}

	===REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI===		===REFINED STRUCTURE IN SOLUTION OF THE SEA ANEMONE NEUROTOXIN SHI===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_7901218}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 7901218 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_7901218}}		{{ABSTRACT_PUBMED_7901218}}

	==About this Structure==		==About this Structure==
-	~~1SHI~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].	+	[[1shi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~7901218~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:007901218</ref><references group="xtra"/>
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
	[[Category: Dyke, T R.]]		[[Category: Dyke, T R.]]
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	[[Category: Pallaghy, P K.]]		[[Category: Pallaghy, P K.]]
	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:25:52 2009''

OCA at 16:25, 17 February 2009

2009-02-17T16:25:53Z

←Older revision		Revision as of 16:25, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1SHI is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].	+	1SHI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHI OCA].

	==Reference==		==Reference==
-	~~Refined structure in solution of the sea anemone neurotoxin ShI., Wilcox GR, Fogh RH, Norton RS, J Biol Chem. 1993 Nov 25;268(33):24707-19.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/7901218 7901218]~~	+	<ref group="xtra">PMID:7901218</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Stichodactyla helianthus]]		[[Category: Stichodactyla helianthus]]
	[[Category: Dyke, T R.]]		[[Category: Dyke, T R.]]
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	[[Category: Neurotoxin]]		[[Category: Neurotoxin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 02~~:23:~~36 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:25:52 2009''