1t04 - Revision history

OCA at 06:22, 23 August 2023

2023-08-23T06:22:46Z

←Older revision		Revision as of 06:22, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1t04' size='340' side='right'caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1t04' size='340' side='right'caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1b2w\|1b2w]], [[1b4j\|1b4j]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [https://pdbe.org/1t04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [https://www.ebi.ac.uk/pdbsum/1t04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [https://pdbe.org/1t04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [https://www.ebi.ac.uk/pdbsum/1t04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t04 ProSAT]</span></td></tr>
	</table>		</table>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bourne~~, P C~~]]	+	[[Category: Bourne PC]]
-	[[Category: Cloud, G]]	+	[[Category: Cloud G]]
-	[[Category: Edmundson~~, A B~~]]	+	[[Category: Edmundson AB]]
-	[[Category: Landolfi~~, N F~~]]	+	[[Category: Landolfi NF]]
-	[[Category: Terzyan~~, S S~~]]	+	[[Category: Terzyan SS]]
-	[[Category: Vasquez, M]]	+	[[Category: Vasquez M]]
-	~~[[Category: Antibody engineering]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Gamma-interferon]]~~	+
-	~~[[Category: Humanized and chimeric antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Three-dimensional structure~~]]	+

OCA at 09:22, 29 September 2021

2021-09-29T09:22:51Z

←Older revision		Revision as of 09:22, 29 September 2021
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	<StructureSection load='1t04' size='340' side='right'caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1t04' size='340' side='right'caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b2w\|1b2w]], [[1b4j\|1b4j]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [~~http~~://pdbe.org/1t04 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t04 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t04 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [https://pdbe.org/1t04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [https://www.ebi.ac.uk/pdbsum/1t04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t04 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:54, 18 December 2019

2019-12-18T13:54:10Z

←Older revision		Revision as of 13:54, 18 December 2019
Line 1:		Line 1:

	==Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group==		==Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group==
-	<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='1t04' size='340' side='right'caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bourne, P C]]		[[Category: Bourne, P C]]
	[[Category: Cloud, G]]		[[Category: Cloud, G]]

OCA at 07:38, 14 March 2018

2018-03-14T07:38:57Z

←Older revision		Revision as of 07:38, 14 March 2018
Line 1:		Line 1:
		+
	==Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group==		==Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group==
	<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://pdbe.org/1t04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://pdbe.org/1t04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t04 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t0/1t04_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t0/1t04_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:10, 10 February 2016

2016-02-10T06:10:29Z

←Older revision		Revision as of 06:10, 10 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t04 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:08, 11 September 2015

2015-09-11T06:08:21Z

←Older revision		Revision as of 06:08, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://pdbe.org/1t04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t04" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bourne, P C]]		[[Category: Bourne, P C]]
	[[Category: Cloud, G]]		[[Category: Cloud, G]]

OCA at 06:56, 6 January 2015

2015-01-06T06:56:20Z

←Older revision		Revision as of 06:56, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bourne, P C.]]	+	[[Category: Bourne, P C]]
-	[[Category: Cloud, G.]]	+	[[Category: Cloud, G]]
-	[[Category: Edmundson, A B.]]	+	[[Category: Edmundson, A B]]
-	[[Category: Landolfi, N F.]]	+	[[Category: Landolfi, N F]]
-	[[Category: Terzyan, S S.]]	+	[[Category: Terzyan, S S]]
-	[[Category: Vasquez, M.]]	+	[[Category: Vasquez, M]]
	[[Category: Antibody engineering]]		[[Category: Antibody engineering]]
	[[Category: Fab]]		[[Category: Fab]]

OCA at 20:57, 28 September 2014

2014-09-28T20:57:58Z

←Older revision		Revision as of 20:57, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t04.~~png~~\|~~left~~\|200px]]	+	==Three dimensional structure of a humanized anti-IFN-Gamma Fab in C2 space group==
		+	<StructureSection load='1t04' size='340' side='right' caption='[[1t04]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T04 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b2w\|1b2w]], [[1b4j\|1b4j]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t04 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t04 RCSB], [http://www.ebi.ac.uk/pdbsum/1t04 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t0/1t04_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three-dimensional structures were determined for two crystal forms (orthorhombic P2(1)2(1)2(1) and monoclinic C2) of the Fab from the humanized version of a murine monoclonal antibody (AF2) that possesses binding and potent neutralizing activity against human interferon gamma (IFN-gamma). This humanized antibody (HuZAF; USAN name fontolizumab) is currently in phase II clinical trials for the treatment of Crohn's disease. HuZAF exhibits binding and IFN-gamma neutralizing capacities that closely approximate those of the original antibody. It is shown that HuZAF, whose VH domain was designed using a best-sequence-fit approach, is closer structurally to its mouse precursor than is a version whose VH was constructed using a human sequence with lower homology to the original mouse sequence. This work thus offers direct structural evidence in support of the best-sequence-fit approach and adds to previous results of biological and biochemical evaluations of distinctly engineered antibodies that also favored the use of a best-sequence-fit strategy. A second crystal type appeared during attempts to crystallize the Fab-IFN-gamma complex. The antibody-antigen complex that existed in solution dissociated in the crystallization mixture. A conformationally altered but unliganded HuZAF protein crystallized in a different space group (C2), with two Fab molecules in the asymmetric unit. In this crystal lattice, no space was available for accommodating the IFN-gamma antigen. Thus, there are currently three slightly different structures of the HuZAF Fab.

-	~~{{STRUCTURE_1t04\| PDB=1t04 \| SCENE= }}~~	+	Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms.,Bourne PC, Terzyan SS, Cloud G, Landolfi NF, Vasquez M, Edmundson AB Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1761-9. Epub 2004, Sep 23. PMID:15388922<ref>PMID:15388922</ref>

-	~~===Three dimensional structure~~ of ~~a humanized anti-IFN-Gamma Fab in C2 space group===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15388922}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1t04]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015388922<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bourne, P C.]]		[[Category: Bourne, P C.]]

OCA at 16:36, 20 October 2012

2012-10-20T16:36:22Z

←Older revision		Revision as of 16:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1t04]] is a 4 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA].	+	[[1t04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T04 OCA].

	==See Also==		==See Also==

OCA: Protected "1t04" [edit=sysop:move=sysop]

2012-07-26T22:16:28Z

Protected "1t04" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:16, 26 July 2012