1t60 - Revision history

OCA at 06:26, 23 August 2023

2023-08-23T06:26:20Z

←Older revision		Revision as of 06:26, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [https://pdbe.org/1t60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [https://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [https://pdbe.org/1t60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [https://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CO4A1_BOVIN CO4A1_BOVIN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.[UniProtKB:P02463] Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.[UniProtKB:P02462]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bondar, O]]	+	[[Category: Bondar O]]
-	[[Category: Friedman~~, D B~~]]	+	[[Category: Friedman DB]]
-	[[Category: Hudson~~, B G~~]]	+	[[Category: Hudson BG]]
-	[[Category: Shanmugasundararaj, S]]	+	[[Category: Shanmugasundararaj S]]
-	[[Category: Sundaramoorthy, M]]	+	[[Category: Sundaramoorthy M]]
-	[[Category: Vanacore~~, R M]]~~	+	[[Category: Vanacore RM]]
-	~~[[Category: Basement membrane]]~~	+
-	~~[[Category: Nc1 domain]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Type iv collagen~~]]	+

OCA at 09:22, 29 September 2021

2021-09-29T09:22:59Z

←Older revision		Revision as of 09:22, 29 September 2021
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	<StructureSection load='1t60' size='340' side='right'caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1t60' size='340' side='right'caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1T60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [~~http~~://pdbe.org/1t60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [https://pdbe.org/1t60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [https://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 14:23, 18 December 2019

2019-12-18T14:23:39Z

←Older revision		Revision as of 14:23, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of Type IV collagen NC1 domain from bovine lens capsule==		==Crystal structure of Type IV collagen NC1 domain from bovine lens capsule==
-	<StructureSection load='1t60' size='340' side='right' caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='1t60' size='340' side='right'caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T60 FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Collagen\|Collagen]]	+	*[[Collagen 3D structures\|Collagen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Bondar, O]]		[[Category: Bondar, O]]
	[[Category: Friedman, D B]]		[[Category: Friedman, D B]]

OCA at 08:03, 14 March 2018

2018-03-14T08:03:08Z

←Older revision		Revision as of 08:03, 14 March 2018
Line 1:		Line 1:
		+
	==Crystal structure of Type IV collagen NC1 domain from bovine lens capsule==		==Crystal structure of Type IV collagen NC1 domain from bovine lens capsule==
	<StructureSection load='1t60' size='340' side='right' caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='1t60' size='340' side='right' caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://pdbe.org/1t60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://pdbe.org/1t60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t60 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t60_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t60_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:37, 8 February 2016

2016-02-08T01:37:09Z

←Older revision		Revision as of 01:37, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t60 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:39, 10 September 2015

2015-09-10T06:39:54Z

←Older revision		Revision as of 06:39, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://pdbe.org/1t60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1t60" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:26, 6 January 2015

2015-01-06T08:26:21Z

←Older revision		Revision as of 08:26, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T60 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Bondar, O.]]	+	[[Category: Bondar, O]]
-	[[Category: Friedman, D B.]]	+	[[Category: Friedman, D B]]
-	[[Category: Hudson, B G.]]	+	[[Category: Hudson, B G]]
-	[[Category: Shanmugasundararaj, S.]]	+	[[Category: Shanmugasundararaj, S]]
-	[[Category: Sundaramoorthy, M.]]	+	[[Category: Sundaramoorthy, M]]
-	[[Category: Vanacore, R M.]]	+	[[Category: Vanacore, R M]]
	[[Category: Basement membrane]]		[[Category: Basement membrane]]
	[[Category: Nc1 domain]]		[[Category: Nc1 domain]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
	[[Category: Type iv collagen]]		[[Category: Type iv collagen]]

OCA at 22:06, 28 September 2014

2014-09-28T22:06:18Z

←Older revision		Revision as of 22:06, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1t60.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of Type IV collagen NC1 domain from bovine lens capsule==
		+	<StructureSection load='1t60' size='340' side='right' caption='[[1t60]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T60 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m3d\|1m3d]], [[1li1\|1li1]], [[1t61\|1t61]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t60 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t60 RCSB], [http://www.ebi.ac.uk/pdbsum/1t60 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t60_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Collagen IV networks are present in all metazoa and underlie epithelia as a component of basement membranes. The networks are essential for tissue function and are defective in disease. They are assembled by the oligomerization of triple-helical protomers that are linked end-to-end. At the C terminus, two protomers are linked head-to-head by interactions of their trimeric noncollagenous domains, forming a hexamer structure. This linkage in the alpha1.alpha2 network is stabilized by a putative covalent Met-Lys cross-link between the trimer-trimer interface (Than, M. E., Henrich, S., Huber, R., Ries, A., Mann, K., Kuhn, K., Timpl, R., Bourenkov, G. P., Bartunik, H. D., and Bode, W. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 6607-6612) forming a nonreducible dimer that connects the hexamer. In the present study, this cross-link was further investigated by: (a) comparing the 1.5-A resolution crystal structures of the alpha1.alpha2 hexamers from bovine placenta and lens capsule basement membranes, (b) mass spectrometric analysis of monomer and nonreducible dimer subunits of placenta basement membrane hexamers, and (c) hexamer dissociation/re-association studies. The findings rule out the novel Met-Lys cross-link, as well as other covalent cross-links, but establish that the nonreducible dimer is an inherent structural feature of a subpopulation of hexamers. The dimers reflect the reinforced stabilization, by noncovalent forces, of the connection between two adjoining protomers of a network. The reinforcement extends to other types of collagen IV networks, and it underlies the cryptic nature of a B-cell epitope of the alpha3.alpha4.alpha5 hexamer, implicating the stabilization event in the etiology and pathogenesis of Goodpasture autoimmune disease.

-	~~{{STRUCTURE_1t60\| PDB=1t60 \| SCENE= }}~~	+	The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links.,Vanacore RM, Shanmugasundararaj S, Friedman DB, Bondar O, Hudson BG, Sundaramoorthy M J Biol Chem. 2004 Oct 22;279(43):44723-30. Epub 2004 Aug 5. PMID:15299013<ref>PMID:15299013</ref>

-	~~===Crystal structure~~ of ~~Type IV collagen NC1 domain from bovine lens capsule===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15299013}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1t60]] is a 24 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA].~~	+

	==See Also==		==See Also==
	*[[Collagen\|Collagen]]		*[[Collagen\|Collagen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015299013<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Bondar, O.]]		[[Category: Bondar, O.]]

OCA at 08:28, 20 October 2012

2012-10-20T08:28:13Z

←Older revision		Revision as of 08:28, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1t60]] is a 24 chain structure ~~of [[Collagen]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA].	+	[[1t60]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T60 OCA].

	==See Also==		==See Also==

OCA: Protected "1t60" [edit=sysop:move=sysop]

2012-07-25T19:38:14Z

Protected "1t60" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:38, 25 July 2012