1tbw - Revision history

OCA at 08:38, 14 February 2024

2024-02-14T08:38:26Z

←Older revision		Revision as of 08:38, 14 February 2024
Line 3:		Line 3:
	<StructureSection load='1tbw' size='340' side='right'caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1tbw' size='340' side='right'caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canfa Canfa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [https://pdbe.org/1tbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [https://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [~~http~~://pdbe.org/1tbw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~ENPL_CANFA ENPL_CANFA]~~] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).	+	[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	GRP94 is the endoplasmic reticulum paralog of cytoplasmic Hsp90. Models of Hsp90 action posit an ATP-dependent conformational switch in the N-terminal ligand regulatory domain of the chaperone. However, crystal structures of the isolated N-domain of Hsp90 in complex with a variety of ligands have yet to demonstrate such a conformational change. We have determined the structure of the N-domain of GRP94 in complex with ATP, ADP, and AMP. Compared with the N-ethylcarboxamidoadenosine and radicicol-bound forms, these structures reveal a large conformational rearrangement in the protein. The nucleotide-bound form exposes new surfaces that interact to form a biochemically plausible dimer that is reminiscent of those seen in structures of MutL and DNA gyrase. Weak ATP binding and a conformational change in response to ligand identity are distinctive mechanistic features of GRP94 and suggest a model for how GRP94 functions in the absence of co-chaperones and ATP hydrolysis.
-
-	Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone.,Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT J Biol Chem. 2004 Oct 29;279(44):46162-71. Epub 2004 Aug 2. PMID:15292259<ref>PMID:15292259</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tbw" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canfa~~]]	+	[[Category: Canis lupus familiaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dollins~~, D E~~]]	+	[[Category: Dollins DE]]
-	[[Category: Gewirth~~, D T~~]]	+	[[Category: Gewirth DT]]
-	[[Category: Immormino~~, R M~~]]	+	[[Category: Immormino RM]]
-	[[Category: Shaffer~~, P L~~]]	+	[[Category: Shaffer PL]]
-	[[Category: Soldano~~, K L~~]]	+	[[Category: Soldano KL]]
-	[[Category: Walker~~, M A]]~~	+	[[Category: Walker MA]]
-	~~[[Category: Amp]]~~	+
-	~~[[Category: Bergrat]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Grp94]]~~	+
-	~~[[Category: Hsp90~~]]	+

OCA at 11:48, 24 December 2020

2020-12-24T11:48:36Z

←Older revision		Revision as of 11:48, 24 December 2020
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	==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==		==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==
-	<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='1tbw' size='340' side='right'caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://pdbe.org/1tbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://pdbe.org/1tbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Canfa]]		[[Category: Canfa]]
		+	[[Category: Large Structures]]
	[[Category: Dollins, D E]]		[[Category: Dollins, D E]]
	[[Category: Gewirth, D T]]		[[Category: Gewirth, D T]]

OCA at 11:17, 7 October 2017

2017-10-07T11:17:44Z

←Older revision		Revision as of 11:17, 7 October 2017
Line 1:		Line 1:
		+
	==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==		==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==
	<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://pdbe.org/1tbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://pdbe.org/1tbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:45, 9 February 2016

2016-02-09T08:45:23Z

←Older revision		Revision as of 08:45, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 1tbw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 1tbw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Endoplasmin\|Endoplasmin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:34, 10 September 2015

2015-09-10T20:34:41Z

←Older revision		Revision as of 20:34, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Canis_lupus_familiaris Canis lupus familiaris~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canfa Canfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 ~~Canis lupus familiaris~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://pdbe.org/1tbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tbw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canis lupus familiaris~~]]	+	[[Category: Canfa]]
	[[Category: Dollins, D E]]		[[Category: Dollins, D E]]
	[[Category: Gewirth, D T]]		[[Category: Gewirth, D T]]

OCA at 05:48, 25 December 2014

2014-12-25T05:48:48Z

←Older revision		Revision as of 05:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBW FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENPL_CANFA ENPL_CANFA]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
-	[[Category: Dollins, D E.]]	+	[[Category: Dollins, D E]]
-	[[Category: Gewirth, D T.]]	+	[[Category: Gewirth, D T]]
-	[[Category: Immormino, R M.]]	+	[[Category: Immormino, R M]]
-	[[Category: Shaffer, P L.]]	+	[[Category: Shaffer, P L]]
-	[[Category: Soldano, K L.]]	+	[[Category: Soldano, K L]]
-	[[Category: Walker, M A.]]	+	[[Category: Walker, M A]]
	[[Category: Amp]]		[[Category: Amp]]
	[[Category: Bergrat]]		[[Category: Bergrat]]

OCA at 23:08, 28 September 2014

2014-09-28T23:08:11Z

←Older revision		Revision as of 23:08, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1tbw.~~png~~\|~~left~~\|200px]]	+	==Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation==
		+	<StructureSection load='1tbw' size='340' side='right' caption='[[1tbw]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TBW FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qy5\|1qy5]], [[1qy8\|1qy8]], [[1qye\|1qye]], [[1qyh\|1qyh]], [[1tc0\|1tc0]], [[1tc6\|1tc6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 Canis lupus familiaris])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tbw RCSB], [http://www.ebi.ac.uk/pdbsum/1tbw PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	GRP94 is the endoplasmic reticulum paralog of cytoplasmic Hsp90. Models of Hsp90 action posit an ATP-dependent conformational switch in the N-terminal ligand regulatory domain of the chaperone. However, crystal structures of the isolated N-domain of Hsp90 in complex with a variety of ligands have yet to demonstrate such a conformational change. We have determined the structure of the N-domain of GRP94 in complex with ATP, ADP, and AMP. Compared with the N-ethylcarboxamidoadenosine and radicicol-bound forms, these structures reveal a large conformational rearrangement in the protein. The nucleotide-bound form exposes new surfaces that interact to form a biochemically plausible dimer that is reminiscent of those seen in structures of MutL and DNA gyrase. Weak ATP binding and a conformational change in response to ligand identity are distinctive mechanistic features of GRP94 and suggest a model for how GRP94 functions in the absence of co-chaperones and ATP hydrolysis.

-	~~{{STRUCTURE_1tbw\| PDB=1tbw \| SCENE= }}~~	+	Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone.,Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT J Biol Chem. 2004 Oct 29;279(44):46162-71. Epub 2004 Aug 2. PMID:15292259<ref>PMID:15292259</ref>

-	~~===Ligand Induced Conformational Shift in the N-terminal Domain of GRP94~~, ~~Open Conformation===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15292259}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1tbw]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Canis_lupus_familiaris Canis lupus familiaris]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA].~~	+

	==See Also==		==See Also==
	*[[Endoplasmin\|Endoplasmin]]		*[[Endoplasmin\|Endoplasmin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015292259<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Dollins, D E.]]		[[Category: Dollins, D E.]]

OCA at 13:19, 20 October 2012

2012-10-20T13:19:07Z

←Older revision		Revision as of 13:19, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1tbw]] is a 2 chain structure ~~of [[Endoplasmin]]~~ with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA].	+	[[1tbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBW OCA].

	==See Also==		==See Also==

OCA at 11:34, 26 July 2012

2012-07-26T11:34:20Z

←Older revision		Revision as of 11:34, 26 July 2012
Line 1:		Line 1:
	[[Image:1tbw.png\|left\|200px]]		[[Image:1tbw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tbw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1tbw\| PDB=1tbw \| SCENE= }}		{{STRUCTURE_1tbw\| PDB=1tbw \| SCENE= }}

	===Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation===		===Ligand Induced Conformational Shift in the N-terminal Domain of GRP94, Open Conformation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15292259}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15292259 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15292259}}		{{ABSTRACT_PUBMED_15292259}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Endoplasmin]]	+	*[[Endoplasmin\|Endoplasmin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15292259~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015292259</ref><references group="xtra"/>
	[[Category: Canis lupus familiaris]]		[[Category: Canis lupus familiaris]]
	[[Category: Dollins, D E.]]		[[Category: Dollins, D E.]]

OCA: Protected "1tbw" [edit=sysop:move=sysop]

2010-12-27T02:05:40Z

Protected "1tbw" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:05, 27 December 2010