1tcd - Revision history

OCA at 06:35, 9 August 2023

2023-08-09T06:35:41Z

←Older revision		Revision as of 06:35, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='1tcd' size='340' side='right'caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='1tcd' size='340' side='right'caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>~~[https://en.wikipedia.org/wiki/Triose~~-~~phosphate_isomerase Triose-phosphate isomerase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.~~1.~~1 5.3.1.1] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [https://pdbe.org/1tcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [https://www.ebi.ac.uk/pdbsum/1tcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [https://pdbe.org/1tcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [https://www.ebi.ac.uk/pdbsum/1tcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TPIS_TRYCR TPIS_TRYCR]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triose-phosphate isomerase]]~~	+	[[Category: Trypanosoma cruzi]]
-	~~[[Category: Trycr~~]]	+	[[Category: Cabrera N]]
-	[[Category: Cabrera, N]]	+	[[Category: Garza-Ramos G]]
-	[[Category: Garza-Ramos, G]]	+	[[Category: Gomez-Puyou A]]
-	[[Category: Gomez-Puyou, A]]	+	[[Category: Maldonado E]]
-	~~[[Category: Gomez-Puyou, M Tuena De~~]]	+	[[Category: Perez-Montfort R]]
-	[[Category: Maldonado, E]]	+	[[Category: Soriano-Garcia M]]
-	[[Category: Perez-Montfort, R]]	+	[[Category: Tuena De Gomez-Puyou M]]
-	[[Category: Soriano-Garcia, M]]	+
-	[[Category: ~~Alpha~~-~~beta barrel]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Intramolecular oxidoreductase]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Isomerization between glyceraldehyde 3-phosphate and dihydroxyacetone~~]]	+

OCA at 09:25, 29 September 2021

2021-09-29T09:25:29Z

←Older revision		Revision as of 09:25, 29 September 2021
Line 3:		Line 3:
	<StructureSection load='1tcd' size='340' side='right'caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='1tcd' size='340' side='right'caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [~~http~~://pdbe.org/1tcd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tcd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [https://pdbe.org/1tcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [https://www.ebi.ac.uk/pdbsum/1tcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 28:		Line 28:

	==See Also==		==See Also==
-	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]	+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:14, 18 December 2019

2019-12-18T14:14:04Z

←Older revision		Revision as of 14:14, 18 December 2019
Line 1:		Line 1:

	==TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE==		==TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE==
-	<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='1tcd' size='340' side='right'caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trycr]]		[[Category: Trycr]]

OCA at 07:54, 14 March 2018

2018-03-14T07:54:17Z

←Older revision		Revision as of 07:54, 14 March 2018
Line 1:		Line 1:
		+
	==TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE==		==TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE==
	<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://pdbe.org/1tcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://pdbe.org/1tcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tcd ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tc/1tcd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tc/1tcd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tcd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:30, 12 September 2015

2015-09-12T02:30:15Z

←Older revision		Revision as of 02:30, 12 September 2015
Line 2:		Line 2:
	<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://pdbe.org/1tcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tcd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
-	[[Category: ~~Trypanosoma cruzi~~]]	+	[[Category: Trycr]]
	[[Category: Cabrera, N]]		[[Category: Cabrera, N]]
	[[Category: Garza-Ramos, G]]		[[Category: Garza-Ramos, G]]

OCA at 08:15, 6 January 2015

2015-01-06T08:15:29Z

←Older revision		Revision as of 08:15, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Cabrera, N.]]	+	[[Category: Cabrera, N]]
-	[[Category: Garza-Ramos, G.]]	+	[[Category: Garza-Ramos, G]]
-	[[Category: Gomez-Puyou, A.]]	+	[[Category: Gomez-Puyou, A]]
-	[[Category: Gomez-Puyou, M Tuena De.]]	+	[[Category: Gomez-Puyou, M Tuena De]]
-	[[Category: Maldonado, E.]]	+	[[Category: Maldonado, E]]
-	[[Category: Perez-Montfort, R.]]	+	[[Category: Perez-Montfort, R]]
-	[[Category: Soriano-Garcia, M.]]	+	[[Category: Soriano-Garcia, M]]
	[[Category: Alpha-beta barrel]]		[[Category: Alpha-beta barrel]]
	[[Category: Glycolysis]]		[[Category: Glycolysis]]

OCA at 22:00, 29 September 2014

2014-09-29T22:00:04Z

←Older revision		Revision as of 22:00, 29 September 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_1tcd~~\| ~~PDB~~=1tcd \| ~~SCENE~~= }}	+	==TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE==
-	===~~TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE~~===	+	<StructureSection load='1tcd' size='340' side='right' caption='[[1tcd]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~{{ABSTRACT_PUBMED_9761683}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TCD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tcd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tcd RCSB], [http://www.ebi.ac.uk/pdbsum/1tcd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tc/1tcd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The aligned amino acid sequences of TIM from Trypanosoma cruzi (TcTIM) and Trypanosoma brucei (TbTIM) have a positional identity of 68%. The two enzymes have markedly similar catalytic properties. Agents that interact with their interface Cys inhibit TcTIM and TbTIM; and those TIMs that lack this Cys (such as human TIM) are largely or completely insensitive to these agents. The susceptibility of TcTIM to the agents is approximately 100 times higher than that of TbTIM. To ascertain the cause of this large difference, the crystal structure of TcTIM was solved at 1.83 A resolution. The two enzymes are very similar homodimers. In TcTIM and TbTIM their respective Cys, 15 or 14, forms part of the dimer interface. In both, the contacts of the Cys with residues of the other subunit are almost identical. Nevertheless, there are noteworthy differences between the two; the existence of glutamine 18 in TbTIM instead of glutamic acid in TcTIM at the beginning of helix 1 decreases the contacts between this portion of the protein and helix 3 of the other subunit. In addition, TcTIM has proline at position 24 in the first helix of the TIM barrel; this is absent in the other TIM. Pro24 disrupts the regular helix arrangement, making the pitch of this helix 1.2 A longer than in TbTIM. When Pro24 of TcTIM was substituted for Glu, the sensitivity of TcTIM to sulfhydryl reagents increased about fivefold, possibly as a consequence of an increase in the space between the first portion of helix 1 and helix 3 of the other subunit. Therefore, it may be concluded that the geometry of the latter region is central in the accessibility to agents that perturb the interface Cys. In human TIM this region is more compact.

-	~~==About this Structure==~~	+	Differences in the intersubunit contacts in triosephosphate isomerase from two closely related pathogenic trypanosomes.,Maldonado E, Soriano-Garcia M, Moreno A, Cabrera N, Garza-Ramos G, de Gomez-Puyou M, Gomez-Puyou A, Perez-Montfort R J Mol Biol. 1998;283(1):193-203. PMID:9761683<ref>PMID:9761683</ref>
-	~~[[1tcd]] is a 2 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1TCD OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:009761683<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]

OCA at 11:05, 11 March 2013

2013-03-11T11:05:54Z

←Older revision		Revision as of 11:05, 11 March 2013
Line 1:		Line 1:
-	[[Image:1tcd.png\|left\|200px]]
-
	{{STRUCTURE_1tcd\| PDB=1tcd \| SCENE= }}		{{STRUCTURE_1tcd\| PDB=1tcd \| SCENE= }}
-
	===TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE===		===TRYPANOSOMA CRUZI TRIOSEPHOSPHATE ISOMERASE===
-
	{{ABSTRACT_PUBMED_9761683}}		{{ABSTRACT_PUBMED_9761683}}

OCA at 22:31, 20 October 2012

2012-10-20T22:31:50Z

←Older revision		Revision as of 22:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1tcd]] is a 2 chain structure ~~of [[Triose Phosphate Isomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA].	+	[[1tcd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA].

	==See Also==		==See Also==

OCA at 02:48, 29 August 2012

2012-08-29T02:48:11Z

←Older revision		Revision as of 02:48, 29 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1tcd]] is a 2 chain structure of ~~[[TIM test]] and~~ [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA].	+	[[1tcd]] is a 2 chain structure of [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TCD OCA].

	==See Also==		==See Also==
-	*[[TIM test\|TIM test]]
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]