1tjd - Revision history

OCA at 06:30, 23 August 2023

2023-08-23T06:30:48Z

←Older revision		Revision as of 06:30, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='1tjd' size='340' side='right'caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1tjd' size='340' side='right'caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TJD FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~>~~</tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide~~-~~isomerase Protein disulfide-isomerase]~~, ~~with EC number~~ [~~http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=~~5~~.3.4.1 5.3.4.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [https://pdbe.org/1tjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [https://www.ebi.ac.uk/pdbsum/1tjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjd ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [~~http~~://pdbe.org/1tjd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tjd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DSBC_ECOLI DSBC_ECOLI]] Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD.<ref>PMID:19965429</ref>	+	[https://www.uniprot.org/uniprot/DSBC_ECOLI DSBC_ECOLI] Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD.<ref>PMID:19965429</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein disulfide-isomerase]]~~	+	[[Category: Banaszak K]]
-	[[Category: Banaszak, K]]	+	[[Category: Frost G]]
-	[[Category: Frost, G]]	+	[[Category: Mechin I]]
-	[[Category: Mechin, I]]	+	[[Category: Rypniewski W]]
-	[[Category: Rypniewski, W]]	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 11:53, 24 December 2020

2020-12-24T11:53:10Z

←Older revision		Revision as of 11:53, 24 December 2020
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	==The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli==		==The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli==
-	<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='1tjd' size='340' side='right'caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TJD FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://pdbe.org/1tjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://pdbe.org/1tjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Thiol:disulfide interchange protein\|Thiol:disulfide interchange protein]]	+	*[[Thiol:disulfide interchange protein 3D structures\|Thiol:disulfide interchange protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
	[[Category: Banaszak, K]]		[[Category: Banaszak, K]]

OCA at 08:38, 21 March 2018

2018-03-21T08:38:58Z

←Older revision		Revision as of 08:38, 21 March 2018
Line 1:		Line 1:
		+
	==The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli==		==The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli==
	<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://pdbe.org/1tjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://pdbe.org/1tjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:45, 9 February 2016

2016-02-09T07:45:45Z

←Older revision		Revision as of 07:45, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tjd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:06, 10 September 2015

2015-09-10T20:06:38Z

←Older revision		Revision as of 20:06, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJD FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://pdbe.org/1tjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tjd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thiol:disulfide interchange protein\|Thiol:disulfide interchange protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
	[[Category: Banaszak, K]]		[[Category: Banaszak, K]]

OCA at 05:28, 25 December 2014

2014-12-25T05:28:45Z

←Older revision		Revision as of 05:28, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJD FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DSBC_ECOLI DSBC_ECOLI]] Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD.<ref>PMID:19965429</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
-	[[Category: Banaszak, K.]]	+	[[Category: Banaszak, K]]
-	[[Category: Frost, G.]]	+	[[Category: Frost, G]]
-	[[Category: Mechin, I.]]	+	[[Category: Mechin, I]]
-	[[Category: Rypniewski, W.]]	+	[[Category: Rypniewski, W]]
	[[Category: Dimer]]		[[Category: Dimer]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 20:55, 29 September 2014

2014-09-29T20:55:46Z

←Older revision		Revision as of 20:55, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1tjd.~~png\|left~~\|200px]]	+	==The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli==
		+	<StructureSection load='1tjd' size='340' side='right' caption='[[1tjd]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSBC, XPRA, B2893, Z4231, ECS3765 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tjd RCSB], [http://www.ebi.ac.uk/pdbsum/1tjd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Disufide-bond isomerase (DsbC) plays a crucial role in folding periplasmically excreted bacterial proteins. The crystal structure of the reduced form of DsbC is presented. The pair of thiol groups from Cys98 and Cys101 that form the reversible disulfide bond in the enzymatic active site are 3.1 A apart and the electron density clearly shows that the S atoms do not form a covalent bond. The other pair of Cys residues (141 and 163) in DsbC form a disulfide bond. This is different from the previously reported crystal form of DsbC (McCarthy et al., 2000), in which both Cys pairs are oxidized. Specific hydrogen-bond interactions are identified that stabilize the active site in the reactive reduced state with the special participation of hydrogen bonds between the active-site cysteine residues (98 and 101) and threonine residues 94 and 182. The present structure also differs in the orientation of the catalytic domains within the protein dimer. This is evidence of flexibility within the protein that probably plays a role in accommodating the substrates in the cleft between the catalytic domains.

-	~~{{STRUCTURE_1tjd\| PDB=1tjd \| SCENE= }}~~	+	Structure of the reduced disulfide-bond isomerase DsbC from Escherichia coli.,Banaszak K, Mechin I, Frost G, Rypniewski W Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1747-52. Epub 2004, Sep 23. PMID:15388920<ref>PMID:15388920</ref>

-	~~===The crystal structure~~ of the ~~reduced disulphide bond isomerase, DsbC, from Escherichia coli===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15388920}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tjd]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015388920<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]

OCA: Protected "1tjd" [edit=sysop:move=sysop]

2013-01-05T11:52:08Z

Protected "1tjd" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:52, 5 January 2013

OCA at 11:52, 5 January 2013

2013-01-05T11:52:06Z

←Older revision		Revision as of 11:52, 5 January 2013
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-	{{Seed}}
	[[Image:1tjd.png\|left\|200px]]		[[Image:1tjd.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1tjd\| PDB=1tjd \| SCENE= }}		{{STRUCTURE_1tjd\| PDB=1tjd \| SCENE= }}

	===The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli===		===The crystal structure of the reduced disulphide bond isomerase, DsbC, from Escherichia coli===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15388920}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15388920 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15388920}}		{{ABSTRACT_PUBMED_15388920}}

	==About this Structure==		==About this Structure==
-	~~1TJD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA].	+	[[1tjd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15388920~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015388920</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
Line 31:		Line 19:
	[[Category: Rypniewski, W.]]		[[Category: Rypniewski, W.]]
	[[Category: Dimer]]		[[Category: Dimer]]
-		+	[[Category: Isomerase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 08:05:09 2009''~~	+

OCA at 06:05, 17 February 2009

2009-02-17T06:05:09Z

←Older revision		Revision as of 06:05, 17 February 2009
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	==About this Structure==		==About this Structure==
-	1TJD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA].	+	1TJD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJD OCA].

	==Reference==		==Reference==
-	Structure of the reduced disulfide-bond isomerase DsbC from Escherichia coli., Banaszak K, Mechin I, Frost G, Rypniewski W, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1747-52. Epub 2004, Sep 23. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/15388920 15388920]~~	+	<ref group="xtra">PMID:15388920</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
-	[[Category: Single protein]]
	[[Category: Banaszak, K.]]		[[Category: Banaszak, K.]]
	[[Category: Frost, G.]]		[[Category: Frost, G.]]
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	[[Category: Dimer]]		[[Category: Dimer]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 11~~:27:~~57 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:05:09 2009''