1tlj - Revision history

OCA at 08:40, 14 February 2024

2024-02-14T08:40:19Z

←Older revision		Revision as of 08:40, 14 February 2024
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	<StructureSection load='1tlj' size='340' side='right'caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlj' size='340' side='right'caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SSO0622, C08_028 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [~~http~~://pdbe.org/1tlj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlj ProSAT], [~~http~~://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [https://pdbe.org/1tlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [https://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlj ProSAT], [https://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~TYW3_SULSO TYW3_SULSO]~~] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.[HAMAP-Rule:MF_00266]	+	[https://www.uniprot.org/uniprot/TYW3_SACS2 TYW3_SACS2] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.[HAMAP-Rule:MF_00266]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlj ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	S-adenosylmethionine (SAM)-dependent methyltransferases regulate a wide range of biological processes through the modification of proteins, nucleic acids, polysaccharides, as well as various metabolites. TYW3/Taw3 is a SAM-dependent methyltransferase responsible for the formation of a tRNA modification known as wybutosine and its derivatives that are required for accurate decoding in protein synthesis. Here, we report the crystal structure of Taw3, a homolog of TYW3 from Sulfolobus solfataricus, which revealed a novel alpha/beta fold. The sequence motif (S/T)xSSCxGR and invariant aspartate and histidine, conserved in TYW3/Taw3, cluster to form the catalytic center. These structural and sequence features indicate that TYW3/Taw3 proteins constitute a distinct class of SAM-dependent methyltransferases. Using site-directed mutagenesis along with in vivo complementation assays combined with mass spectrometry as well as ligand docking and cofactor binding assays, we have identified the active site of TYW3 and residues essential for cofactor binding and methyltransferase activity.
-
-	Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases.,Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z RNA. 2017 Mar;23(3):346-354. doi: 10.1261/rna.057943.116. Epub 2016 Dec 8. PMID:27932585<ref>PMID:27932585</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1tlj" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 35091]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Edwards, A~~]]	+	[[Category: Saccharolobus solfataricus]]
-	[[Category: ~~Jia, Z~~]]	+	[[Category: Edwards A]]
-	[[Category: ~~Kudrytska, M~~]]	+	[[Category: Jia Z]]
-	[[Category: ~~Structural genomic~~]]	+	[[Category: Kudrytska M]]
-	[[Category: Savchenko, A]]	+	[[Category: Savchenko A]]
-	[[Category: Skarina, T]]	+	[[Category: Skarina T]]
-	[[Category: Walker, J]]	+	[[Category: Walker J]]
-	[[Category: Wong~~, A H.Y]]~~	+	[[Category: Wong AHY]]
-	~~[[Category: Mcsg]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Sso0622]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 11:14, 29 July 2020

2020-07-29T11:14:55Z

←Older revision		Revision as of 11:14, 29 July 2020
Line 1:		Line 1:

	==Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus==		==Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus==
-	<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='1tlj' size='340' side='right'caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://pdbe.org/1tlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlj ProSAT], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://pdbe.org/1tlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlj ProSAT], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlj ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-adenosylmethionine (SAM)-dependent methyltransferases regulate a wide range of biological processes through the modification of proteins, nucleic acids, polysaccharides, as well as various metabolites. TYW3/Taw3 is a SAM-dependent methyltransferase responsible for the formation of a tRNA modification known as wybutosine and its derivatives that are required for accurate decoding in protein synthesis. Here, we report the crystal structure of Taw3, a homolog of TYW3 from Sulfolobus solfataricus, which revealed a novel alpha/beta fold. The sequence motif (S/T)xSSCxGR and invariant aspartate and histidine, conserved in TYW3/Taw3, cluster to form the catalytic center. These structural and sequence features indicate that TYW3/Taw3 proteins constitute a distinct class of SAM-dependent methyltransferases. Using site-directed mutagenesis along with in vivo complementation assays combined with mass spectrometry as well as ligand docking and cofactor binding assays, we have identified the active site of TYW3 and residues essential for cofactor binding and methyltransferase activity.
		+
		+	Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases.,Currie MA, Brown G, Wong A, Ohira T, Sugiyama K, Suzuki T, Yakunin AF, Jia Z RNA. 2017 Mar;23(3):346-354. doi: 10.1261/rna.057943.116. Epub 2016 Dec 8. PMID:27932585<ref>PMID:27932585</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 1tlj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Atcc 35091]]		[[Category: Atcc 35091]]
		+	[[Category: Large Structures]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]

OCA at 08:33, 21 March 2018

2018-03-21T08:33:43Z

←Older revision		Revision as of 08:33, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus==		==Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus==
	<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://pdbe.org/1tlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://pdbe.org/1tlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlj ProSAT], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:56, 9 February 2016

2016-02-09T21:56:39Z

←Older revision		Revision as of 21:56, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__

OCA at 02:24, 11 September 2015

2015-09-11T02:24:55Z

←Older revision		Revision as of 02:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ~~Sulfolobus solfataricus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://pdbe.org/1tlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Y622_SULSO Y622_SULSO~~]] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 ~~(By similarity)~~.	+	[[http://www.uniprot.org/uniprot/TYW3_SULSO TYW3_SULSO]] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.[HAMAP-Rule:MF_00266]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sulfolobus solfataricus~~]]	+	[[Category: Atcc 35091]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]

OCA at 09:48, 25 December 2014

2014-12-25T09:48:26Z

←Older revision		Revision as of 09:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Y622_SULSO Y622_SULSO]] S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Jia, Z.]]	+	[[Category: Jia, Z]]
-	[[Category: Kudrytska, M.]]	+	[[Category: Kudrytska, M]]
-	[[Category: ~~MCSG, Midwest Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Savchenko, A.]]	+	[[Category: Savchenko, A]]
-	[[Category: Skarina, T.]]	+	[[Category: Skarina, T]]
-	[[Category: Walker, J.]]	+	[[Category: Walker, J]]
-	[[Category: Wong, A H.Y.]]	+	[[Category: Wong, A H.Y]]
	[[Category: Mcsg]]		[[Category: Mcsg]]
-	[[Category: ~~Midwest center for structural genomic]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi~~]]	+
	[[Category: Sso0622]]		[[Category: Sso0622]]
-	[[Category: Structural genomic]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 20:52, 29 September 2014

2014-09-29T20:52:39Z

←Older revision		Revision as of 20:52, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:1tlj.png\|left\|200px]]~~	+	==Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus==
-		+	<StructureSection load='1tlj' size='340' side='right' caption='[[1tlj]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{STRUCTURE_1tlj\| PDB=1tlj \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TLJ FirstGlance]. <br>
-	===Crystal Structure of Conserved Protein of Unknown Function SSO0622 from Sulfolobus solfataricus===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SSO0622, C08_028 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tlj RCSB], [http://www.ebi.ac.uk/pdbsum/1tlj PDBsum], [http://www.topsan.org/Proteins/MCSG/1tlj TOPSAN]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A.]]

OCA: Protected "1tlj" [edit=sysop:move=sysop]

2013-01-05T11:47:40Z

Protected "1tlj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:47, 5 January 2013

OCA at 11:47, 5 January 2013

2013-01-05T11:47:38Z

←Older revision		Revision as of 11:47, 5 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1tlj.png\|left\|200px]]		[[Image:1tlj.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tlj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1tlj\| PDB=1tlj \| SCENE= }}		{{STRUCTURE_1tlj\| PDB=1tlj \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~1TLJ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA].	+	[[1tlj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA].
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A.]]
Line 29:		Line 22:
	[[Category: Psi]]		[[Category: Psi]]
	[[Category: Sso0622]]		[[Category: Sso0622]]
-		+	[[Category: Structural genomic]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Sun Nov 16 16~~:~~00:46 2008''~~	+	[[Category: Unknown function]]

OCA at 14:00, 16 November 2008

2008-11-16T14:00:48Z

←Older revision		Revision as of 14:00, 16 November 2008
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	1TLJ is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA].	+	1TLJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLJ OCA].
-	~~[[Category: Single protein]]~~	+
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Edwards, A.]]		[[Category: Edwards, A.]]
Line 31:		Line 30:
	[[Category: Sso0622]]		[[Category: Sso0622]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Sep 29 02~~:06:06 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 16:00:46 2008''