1ton - Revision history

OCA at 08:43, 1 May 2024

2024-05-01T08:43:02Z

←Older revision		Revision as of 08:43, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='1ton' size='340' side='right'caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ton' size='340' side='right'caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Black_rat Black rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TON FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TON FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [https://pdbe.org/1ton PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [https://www.ebi.ac.uk/pdbsum/1ton PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ton ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [https://pdbe.org/1ton PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [https://www.ebi.ac.uk/pdbsum/1ton PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ton ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KLK2_RAT KLK2_RAT]] This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.	+	[https://www.uniprot.org/uniprot/KLK2_RAT KLK2_RAT] This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ton ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ton ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Tonin is a mammalian serine protease that is capable of generating the vasoconstrictive agent, angiotensin II, directly from its precursor protein, angiotensinogen, a process that normally requires two enzymes, renin and angiotensin-converting enzyme. The X-ray crystallographic structure determination and refinement of tonin at 1.8 A resolution and the analysis of the resulting model are reported. The initial phases were obtained by the method of molecular replacement using as the search model the structure of bovine trypsin. The refined model of tonin consists of 227 amino acid residues out of the 235 in the complete molecule, 149 water molecules, and one zinc ion. The R-factor (R = sigma Fo - Fc/sigma Fo) is 0.196 for the 14,997 measured data between 8 and 1.8 A resolution with I greater than or equal to sigma (I). It is estimated that the overall root-mean-square error in the coordinates is about 0.3 A. The structure of tonin that has been determined is not in its active conformation, but one that has been perturbed by the binding of Zn2+ in the active site. Zn2+ was included in the buffer to aid the crystallization. Nevertheless, the structure of tonin that is described is for the most part similar to its native form as indicated by the close tertiary structural homology with kallikrein. The differences in the structures of the two enzymes are concentrated in several loop regions; these structural differences are probably responsible for the differences in their reactivities and specificities.
-
-	Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.,Fujinaga M, James MN J Mol Biol. 1987 May 20;195(2):373-96. PMID:2821276<ref>PMID:2821276</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 1ton" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Black rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fujinaga, M]]	+	[[Category: Rattus rattus]]
-	[[Category: James~~, M N.G~~]]	+	[[Category: Fujinaga M]]
		+	[[Category: James MNG]]

OCA at 09:30, 29 September 2021

2021-09-29T09:30:24Z

←Older revision		Revision as of 09:30, 29 September 2021
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	<StructureSection load='1ton' size='340' side='right'caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ton' size='340' side='right'caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TON FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TON FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [~~http~~://pdbe.org/1ton PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1ton PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1ton ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [https://pdbe.org/1ton PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [https://www.ebi.ac.uk/pdbsum/1ton PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ton ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KLK2_RAT KLK2_RAT]] This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.	+	[[https://www.uniprot.org/uniprot/KLK2_RAT KLK2_RAT]] This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:27, 4 December 2019

2019-12-04T11:27:43Z

←Older revision		Revision as of 11:27, 4 December 2019
Line 1:		Line 1:

	==RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION==		==RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION==
-	<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='1ton' size='340' side='right'caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1ton_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1ton_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Black rat]]		[[Category: Black rat]]
		+	[[Category: Large Structures]]
	[[Category: Fujinaga, M]]		[[Category: Fujinaga, M]]
	[[Category: James, M N.G]]		[[Category: James, M N.G]]

OCA at 06:59, 29 November 2017

2017-11-29T06:59:25Z

←Older revision		Revision as of 06:59, 29 November 2017
Line 1:		Line 1:
		+
	==RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION==		==RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION==
	<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://pdbe.org/1ton PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://pdbe.org/1ton PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ton ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:06, 9 February 2016

2016-02-09T15:06:26Z

←Older revision		Revision as of 15:06, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ton ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:25, 10 September 2015

2015-09-10T23:25:25Z

←Older revision		Revision as of 23:25, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_rattus Rattus rattus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_rat Black rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://pdbe.org/1ton PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1ton" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus rattus~~]]	+	[[Category: Black rat]]
	[[Category: Fujinaga, M]]		[[Category: Fujinaga, M]]
	[[Category: James, M N.G]]		[[Category: James, M N.G]]

OCA at 07:35, 25 December 2014

2014-12-25T07:35:31Z

←Older revision		Revision as of 07:35, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>		<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLK2_RAT KLK2_RAT]] This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
-	[[Category: Fujinaga, M.]]	+	[[Category: Fujinaga, M]]
-	[[Category: James, M N.G.]]	+	[[Category: James, M N.G]]

OCA at 19:04, 29 September 2014

2014-09-29T19:04:05Z

←Older revision		Revision as of 19:04, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1ton.~~png\|left~~\|200px]]	+	==RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION==
		+	<StructureSection load='1ton' size='340' side='right' caption='[[1ton]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TON FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ton OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ton RCSB], [http://www.ebi.ac.uk/pdbsum/1ton PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/to/1ton_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tonin is a mammalian serine protease that is capable of generating the vasoconstrictive agent, angiotensin II, directly from its precursor protein, angiotensinogen, a process that normally requires two enzymes, renin and angiotensin-converting enzyme. The X-ray crystallographic structure determination and refinement of tonin at 1.8 A resolution and the analysis of the resulting model are reported. The initial phases were obtained by the method of molecular replacement using as the search model the structure of bovine trypsin. The refined model of tonin consists of 227 amino acid residues out of the 235 in the complete molecule, 149 water molecules, and one zinc ion. The R-factor (R = sigma Fo - Fc/sigma Fo) is 0.196 for the 14,997 measured data between 8 and 1.8 A resolution with I greater than or equal to sigma (I). It is estimated that the overall root-mean-square error in the coordinates is about 0.3 A. The structure of tonin that has been determined is not in its active conformation, but one that has been perturbed by the binding of Zn2+ in the active site. Zn2+ was included in the buffer to aid the crystallization. Nevertheless, the structure of tonin that is described is for the most part similar to its native form as indicated by the close tertiary structural homology with kallikrein. The differences in the structures of the two enzymes are concentrated in several loop regions; these structural differences are probably responsible for the differences in their reactivities and specificities.

-	~~{{STRUCTURE_1ton\| PDB=1ton \| SCENE= }}~~	+	Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 A resolution.,Fujinaga M, James MN J Mol Biol. 1987 May 20;195(2):373-96. PMID:2821276<ref>PMID:2821276</ref>

-	~~===RAT SUBMAXILLARY GLAND SERINE PROTEASE~~, ~~TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_2821276}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1ton]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_rattus Rattus rattus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:002821276<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
	[[Category: Fujinaga, M.]]		[[Category: Fujinaga, M.]]
	[[Category: James, M N.G.]]		[[Category: James, M N.G.]]

OCA: Protected "1ton" [edit=sysop:move=sysop]

2013-01-05T11:55:36Z

Protected "1ton" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:55, 5 January 2013

OCA at 11:55, 5 January 2013

2013-01-05T11:55:32Z

←Older revision		Revision as of 11:55, 5 January 2013
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	[[Image:1ton.png\|left\|200px]]		[[Image:1ton.png\|left\|200px]]

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	{{STRUCTURE_1ton\| PDB=1ton \| SCENE= }}		{{STRUCTURE_1ton\| PDB=1ton \| SCENE= }}

	===RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION===		===RAT SUBMAXILLARY GLAND SERINE PROTEASE, TONIN. STRUCTURE SOLUTION AND REFINEMENT AT 1.8 ANGSTROMS RESOLUTION===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_2821276}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 2821276 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_2821276}}		{{ABSTRACT_PUBMED_2821276}}

	==About this Structure==		==About this Structure==
-	~~1TON~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA].	+	[[1ton]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TON OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~2821276~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:002821276</ref><references group="xtra"/>
	[[Category: Rattus rattus]]		[[Category: Rattus rattus]]
	[[Category: Fujinaga, M.]]		[[Category: Fujinaga, M.]]
	[[Category: James, M N.G.]]		[[Category: James, M N.G.]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:42:13 2009''