1tv0 - Revision history

OCA at 09:26, 6 December 2023

2023-12-06T09:26:24Z

←Older revision		Revision as of 09:26, 6 December 2023
Line 1:		Line 1:

	==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==		==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==
-	<StructureSection load='1tv0' size='340' side='right'caption='[[1tv0~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='1tv0' size='340' side='right'caption='[[1tv0]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>DEFCR4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [https://pdbe.org/1tv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [https://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [https://pdbe.org/1tv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [https://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DEFA4_MOUSE DEFA4_MOUSE] Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Hunter~~, H N~~]]	+	[[Category: Hunter HN]]
-	[[Category: Jing, W]]	+	[[Category: Jing W]]
-	[[Category: Ouellette~~, A J~~]]	+	[[Category: Ouellette AJ]]
-	[[Category: Tanabe, H]]	+	[[Category: Tanabe H]]
-	[[Category: Vogel~~, H J]]~~	+	[[Category: Vogel HJ]]
-	~~[[Category: Antimicrobial protein]]~~	+
-	~~[[Category: Beta hairpin]]~~	+
-	~~[[Category: Beta sheet~~]]	+

OCA at 06:41, 2 March 2022

2022-03-02T06:41:39Z

←Older revision		Revision as of 06:41, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='1tv0' size='340' side='right'caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1tv0' size='340' side='right'caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [~~http~~://pdbe.org/1tv0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [https://pdbe.org/1tv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [https://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:00, 24 December 2020

2020-12-24T12:00:45Z

←Older revision		Revision as of 12:00, 24 December 2020
Line 1:		Line 1:

	==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==		==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==
-	<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='1tv0' size='340' side='right'caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://pdbe.org/1tv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://pdbe.org/1tv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Hunter, H N]]		[[Category: Hunter, H N]]

OCA at 08:53, 21 March 2018

2018-03-21T08:53:35Z

←Older revision		Revision as of 08:53, 21 March 2018
Line 1:		Line 1:
		+
	==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==		==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==
	<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://pdbe.org/1tv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://pdbe.org/1tv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tv0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:20, 10 September 2015

2015-09-10T11:20:09Z

←Older revision		Revision as of 11:20, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://pdbe.org/1tv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 14:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1tv0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Hunter, H N]]		[[Category: Hunter, H N]]
	[[Category: Jing, W]]		[[Category: Jing, W]]

OCA at 06:40, 22 December 2014

2014-12-22T06:40:23Z

←Older revision		Revision as of 06:40, 22 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Hunter, H N.]]	+	[[Category: Hunter, H N]]
-	[[Category: Jing, W.]]	+	[[Category: Jing, W]]
-	[[Category: Ouellette, A J.]]	+	[[Category: Ouellette, A J]]
-	[[Category: Tanabe, H.]]	+	[[Category: Tanabe, H]]
-	[[Category: Vogel, H J.]]	+	[[Category: Vogel, H J]]
	[[Category: Antimicrobial protein]]		[[Category: Antimicrobial protein]]
	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]

OCA at 07:06, 9 June 2014

2014-06-09T07:06:36Z

←Older revision		Revision as of 07:06, 9 June 2014
Line 1:		Line 1:
-	[[~~Image:~~1tv0.~~png~~\|~~left\|200px~~]]	+	==Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells==
		+	<StructureSection load='1tv0' size='340' side='right' caption='[[1tv0]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TV0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DEFCR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1tv0 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian defensins are abundant antimicrobial peptides that contribute to host defense. They are characterized by several conserved amino acids, including six invariant cysteine residues which form three intramolecular disulfide bonds and stabilize the tertiary structure. Cryptdin-4 (Crp4), a mouse alpha-defensin with potent in vitro bactericidal activity, has a primary structure distinct from all known alpha-defensins in that its polypeptide backbone uniquely lacks three residues between Cys(IV) and Cys(V). NMR diffusion experiments showed that Crp4 is monomeric in solution, and its three-dimensional solution structure, determined by two-dimensional proton NMR, consists of a triple-stranded antiparallel beta-sheet with the beta-strands joined to each other by a series of tight turns and a beta-hairpin. However, the overall beta-sheet content in Crp4 is lower than that of other alpha-defensin structures, while the shape and orientation of the Crp4 beta-hairpin also differ from those of other alpha-defensin structures. These structural characteristics combined with the high overall cationicity of Crp4 may contribute to its broad bactericidal spectrum and membrane disruptive activity.

-	~~{{STRUCTURE_1tv0\| PDB=1tv0 \| SCENE= }}~~	+	Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin.,Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ Biochemistry. 2004 Dec 21;43(50):15759-66. PMID:15595831<ref>PMID:15595831</ref>

-	~~===Solution structure~~ of ~~cryptdin-4,~~ the ~~most potent alpha-defensin from mouse Paneth cells===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15595831}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[1tv0]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:015595831<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hunter, H N.]]		[[Category: Hunter, H N.]]

OCA: Protected "1tv0" [edit=sysop:move=sysop]

2012-08-14T18:57:46Z

Protected "1tv0" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:57, 14 August 2012

OCA at 18:57, 14 August 2012

2012-08-14T18:57:44Z

←Older revision		Revision as of 18:57, 14 August 2012
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-	{{Seed}}
	[[Image:1tv0.png\|left\|200px]]		[[Image:1tv0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1tv0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_1tv0\| PDB=1tv0 \| SCENE= }}		{{STRUCTURE_1tv0\| PDB=1tv0 \| SCENE= }}

	===Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells===		===Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15595831}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15595831 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_15595831}}		{{ABSTRACT_PUBMED_15595831}}

	==About this Structure==		==About this Structure==
-	~~1TV0 is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].	+	[[1tv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].

	==Reference==		==Reference==
-	~~Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin., Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ, Biochemistry. 2004 Dec 21;43(50):15759-66.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~15595831 15595831]~~	+	<ref group="xtra">PMID:015595831</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Hunter, H N.]]		[[Category: Hunter, H N.]]
	[[Category: Jing, W.]]		[[Category: Jing, W.]]
Line 31:		Line 18:
	[[Category: Tanabe, H.]]		[[Category: Tanabe, H.]]
	[[Category: Vogel, H J.]]		[[Category: Vogel, H J.]]
		+	[[Category: Antimicrobial protein]]
	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:45:03 2008''

OCA at 23:45, 27 July 2008

2008-07-27T23:45:06Z

←Older revision		Revision as of 23:45, 27 July 2008
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-	[[Image:1tv0.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:1tv0.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_1tv0\| PDB=1tv0 \| SCENE= }}		{{STRUCTURE_1tv0\| PDB=1tv0 \| SCENE= }}

-	~~'''~~Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells~~'''~~	+	===Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells===


-	~~==Overview==~~	+	<!--
-	Mammalian defensins are abundant antimicrobial peptides that contribute to host defense. They are characterized by several conserved amino acids, including six invariant cysteine residues which form three intramolecular disulfide bonds and stabilize the tertiary structure. Cryptdin-~~4 (Crp4), a mouse alpha~~-~~defensin with potent in vitro bactericidal activity~~, has a primary structure distinct from all known alpha-defensins in that its polypeptide backbone uniquely lacks three residues between Cys(IV) and Cys(V). NMR diffusion experiments showed that Crp4 is monomeric in solution, ~~and its three-dimensional solution structure, determined by two-dimensional proton NMR, consists of a triple-stranded antiparallel beta-sheet with~~ the ~~beta-strands joined~~ to ~~each other by a series of tight turns and a beta-hairpin~~. ~~However~~, ~~the overall beta-sheet content in Crp4~~ is ~~lower than that of other alpha-defensin structures, while~~ the ~~shape and orientation of the Crp4 beta~~-~~hairpin also differ from those of other alpha~~-~~defensin structures. These structural characteristics combined with the high overall cationicity of Crp4 may contribute to its broad bactericidal spectrum and membrane disruptive activity.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_15595831}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15595831 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15595831}}

	==About this Structure==		==About this Structure==
-	1TV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].	+	1TV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TV0 OCA].

	==Reference==		==Reference==
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	[[Category: Beta hairpin]]		[[Category: Beta hairpin]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 10~~:24:05 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:45:03 2008''