1txx - Revision history

OCA at 06:35, 23 August 2023

2023-08-23T06:35:16Z

←Older revision		Revision as of 06:35, 23 August 2023
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	<StructureSection load='1txx' size='340' side='right'caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1txx' size='340' side='right'caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [https://pdbe.org/1txx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [https://www.ebi.ac.uk/pdbsum/1txx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [https://pdbe.org/1txx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [https://www.ebi.ac.uk/pdbsum/1txx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.	+	[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chivers~~, P T~~]]	+	[[Category: Chivers PT]]
-	[[Category: Raines~~, R T~~]]	+	[[Category: Raines RT]]
-	[[Category: Schultz~~, L W]]~~	+	[[Category: Schultz LW]]
-	~~[[Category: Cxxc]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Redox~~]]	+

OCA at 09:34, 29 September 2021

2021-09-29T09:34:06Z

←Older revision		Revision as of 09:34, 29 September 2021
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	<StructureSection load='1txx' size='340' side='right'caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1txx' size='340' side='right'caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1TXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [~~http~~://pdbe.org/1txx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1txx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1txx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [https://pdbe.org/1txx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [https://www.ebi.ac.uk/pdbsum/1txx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.	+	[[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Thioredoxin\|Thioredoxin]]	+	*[[Thioredoxin 3D structures\|Thioredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:14, 18 December 2019

2019-12-18T14:14:31Z

←Older revision		Revision as of 14:14, 18 December 2019
Line 1:		Line 1:

	==ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN==		==ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN==
-	<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='1txx' size='340' side='right'caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Chivers, P T]]		[[Category: Chivers, P T]]
	[[Category: Raines, R T]]		[[Category: Raines, R T]]

OCA at 06:42, 14 March 2018

2018-03-14T06:42:46Z

←Older revision		Revision as of 06:42, 14 March 2018
Line 1:		Line 1:
		+
	==ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN==		==ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN==
	<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://pdbe.org/1txx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://pdbe.org/1txx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1txx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1txx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1txx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:25, 7 February 2016

2016-02-07T07:25:14Z

←Older revision		Revision as of 07:25, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1txx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:09, 9 September 2015

2015-09-09T23:09:14Z

←Older revision		Revision as of 23:09, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://pdbe.org/1txx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1txx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Chivers, P T]]		[[Category: Chivers, P T]]
	[[Category: Raines, R T]]		[[Category: Raines, R T]]

OCA at 08:58, 24 December 2014

2014-12-24T08:58:00Z

←Older revision		Revision as of 08:58, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Chivers, P T.]]	+	[[Category: Chivers, P T]]
-	[[Category: Raines, R T.]]	+	[[Category: Raines, R T]]
-	[[Category: Schultz, L W.]]	+	[[Category: Schultz, L W]]
	[[Category: Cxxc]]		[[Category: Cxxc]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Redox]]		[[Category: Redox]]

OCA at 21:14, 28 September 2014

2014-09-28T21:14:43Z

←Older revision		Revision as of 21:14, 28 September 2014
Line 1:		Line 1:
-	[[~~Image~~:1txx.~~png\|left~~\|200px]]	+	==ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN==
		+	<StructureSection load='1txx' size='340' side='right' caption='[[1txx]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TXX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1txx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1txx RCSB], [http://www.ebi.ac.uk/pdbsum/1txx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1txx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2.2 A crystalline structure of an oxidized active-site variant of Escherichia coli thioredoxin (Trx) has been solved. Trx is a 12 kDa enzyme which catalyzes the oxidation of dithiols and the reduction and isomerization of disulfides in other proteins. Its active site contains the common structural motif CXXC. Protein-disulfide isomerase (PDI), a 57 kDa homolog of Trx, contains four Trx-like domains. The three-dimensional structure of PDI is unknown. PDI-deficient Saccharomyces cerevisiae are inviable. An active-site variant of Trx which complements PDI-deficient yeast has the active-site sequence Cys32-Val33-Trp34-Cys35 (CVWC). The reduction potential of oxidized CVWC Trx (E degrees ' = -0.230 V) is altered significantly from that of the wild-type enzyme (E degrees ' = -0.270 V). However, the structure of the oxidized CVWC enzyme is almost identical to that of wild-type Trx. The addition of valine and tryptophan in the active site is likely to increase the reduction potential, largely by decreasing the pK(a) of the Cys32 thiol in the reduced enzyme. Unlike in wild-type Trx, significant protein-protein contacts occur in the crystal. Protein molecules related by a crystallographic twofold axis form a dimer in the crystal. The dimer forms as an extension of the twisted mixed beta-sheet which composes the backbone of each Trx structure.

-	~~{{STRUCTURE_1txx\| PDB=1txx \| SCENE= }}~~	+	The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin.,Schultz LW, Chivers PT, Raines RT Acta Crystallogr D Biol Crystallogr. 1999 Sep;55(Pt 9):1533-8. PMID:10489448<ref>PMID:10489448</ref>

-	~~===ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_10489448}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1txx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA].~~	+

	==See Also==		==See Also==
	*[[Thioredoxin\|Thioredoxin]]		*[[Thioredoxin\|Thioredoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:010489448<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Chivers, P T.]]		[[Category: Chivers, P T.]]

OCA at 05:59, 20 October 2012

2012-10-20T05:59:04Z

←Older revision		Revision as of 05:59, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[1txx]] is a 1 chain structure ~~of [[Thioredoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA].	+	[[1txx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXX OCA].

	==See Also==		==See Also==

OCA at 11:44, 25 July 2012

2012-07-25T11:44:04Z

←Older revision		Revision as of 11:44, 25 July 2012
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	[[Image:1txx.png\|left\|200px]]		[[Image:1txx.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_1txx\| PDB=1txx \| SCENE= }}		{{STRUCTURE_1txx\| PDB=1txx \| SCENE= }}

	===ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN===		===ACTIVE-SITE VARIANT OF E.COLI THIOREDOXIN===

-
-	<!--
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	{{ABSTRACT_PUBMED_10489448}}		{{ABSTRACT_PUBMED_10489448}}

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	==See Also==		==See Also==
-	*[[Thioredoxin]]	+	*[[Thioredoxin\|Thioredoxin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~10489448~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:010489448</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Chivers, P T.]]		[[Category: Chivers, P T.]]