1u1l - Revision history

OCA at 06:36, 23 August 2023

2023-08-23T06:36:29Z

←Older revision		Revision as of 06:36, 23 August 2023
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	<StructureSection load='1u1l' size='340' side='right'caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u1l' size='340' side='right'caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=1U1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U1L FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[2up1\|2up1]]~~, [[~~1pgz~~\|~~1pgz~~]]~~, [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [https://pdbe.org/1u1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [https://www.ebi.ac.uk/pdbsum/1u1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [~~http~~://pdbe.org/1u1l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1u1l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>	+	[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>	+	[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Myers~~, J C~~]]	+	[[Category: Myers JC]]
-	[[Category: Shamoo, Y]]	+	[[Category: Shamoo Y]]
-	~~[[Category: Hnrnp a1]]~~	+
-	~~[[Category: Htr]]~~	+
-	~~[[Category: Human telomeric repeat]]~~	+
-	~~[[Category: Nebularine]]~~	+
-	~~[[Category: Prn]]~~	+
-	~~[[Category: Protein-dna complex]]~~	+
-	~~[[Category: Rna recognition motif]]~~	+
-	~~[[Category: Rrm]]~~	+
-	~~[[Category: Transport protein-dna complex]]~~	+
-	~~[[Category: Up1~~]]	+

OCA at 07:18, 30 December 2020

2020-12-30T07:18:32Z

←Older revision		Revision as of 07:18, 30 December 2020
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	==Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine==		==Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine==
-	<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='1u1l' size='340' side='right'caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1U1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U1L FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://pdbe.org/1u1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://pdbe.org/1u1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1l ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
-	*[[Nucleoprotein\|Nucleoprotein]]	+	*[[Nucleoprotein 3D structures\|Nucleoprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Myers, J C]]		[[Category: Myers, J C]]
	[[Category: Shamoo, Y]]		[[Category: Shamoo, Y]]

OCA at 09:01, 21 March 2018

2018-03-21T09:01:29Z

←Older revision		Revision as of 09:01, 21 March 2018
Line 1:		Line 1:
		+
	==Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine==		==Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine==
	<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://pdbe.org/1u1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://pdbe.org/1u1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u1l ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1l_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1l_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	==See Also==		==See Also==
-	*[[HnRNP A1\|HnRNP A1]]
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
	== References ==		== References ==

OCA at 11:53, 7 February 2016

2016-02-07T11:53:24Z

←Older revision		Revision as of 11:53, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u1l ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:14, 10 September 2015

2015-09-10T01:14:44Z

←Older revision		Revision as of 01:14, 10 September 2015
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	<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1L FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://pdbe.org/1u1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 1u1l" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[HnRNP A1\|HnRNP A1]]
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Myers, J C]]		[[Category: Myers, J C]]
	[[Category: Shamoo, Y]]		[[Category: Shamoo, Y]]

OCA at 13:09, 6 January 2015

2015-01-06T13:09:25Z

←Older revision		Revision as of 13:09, 6 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1L FirstGlance]. <br>		<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>		[[http://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Myers, J C.]]	+	[[Category: Myers, J C]]
-	[[Category: Shamoo, Y.]]	+	[[Category: Shamoo, Y]]
	[[Category: Hnrnp a1]]		[[Category: Hnrnp a1]]
	[[Category: Htr]]		[[Category: Htr]]

OCA at 22:36, 28 September 2014

2014-09-28T22:36:06Z

←Older revision		Revision as of 22:36, 28 September 2014
Line 1:		Line 1:
-	[[~~Image:~~1u1l.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine==
		+	<StructureSection load='1u1l' size='340' side='right' caption='[[1u1l]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U1L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2up1\|2up1]], [[1pgz\|1pgz]], [[1po6\|1po6]], [[1u1k\|1u1k]], [[1u1m\|1u1m]], [[1u1n\|1u1n]], [[1u1o\|1u1o]], [[1u1p\|1u1p]], [[1u1q\|1u1q]], [[1u1r\|1u1r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HNRPA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u1l RCSB], [http://www.ebi.ac.uk/pdbsum/1u1l PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN]] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u1/1u1l_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterogeneous ribonucleoprotein A1 (hnRNP A1) is a prototype for the family of eukaryotic RNA processing proteins containing the common RNA recognition motif (RRM). The region consisting of residues 1-195 of hnRNP A1 is referred to as UP1. This region has two RRMs and has a high affinity for both single-stranded RNA and the human telomeric repeat sequence d(TTAGGG)(n). We have used UP1's novel DNA binding to investigate how RRMs bind nucleic acid bases through their highly conserved RNP consensus sequences. Nine complexes of UP1 bound to modified telomeric repeats were investigated using equilibrium fluorescence binding and X-ray crystallography. In two of the complexes, alteration of a guanine to either 2-aminopurine or nebularine resulted in an increase in K(d) from 88nM to 209nM and 316nM, respectively. The loss of these orienting interactions between UP1 and the substituted base allows it to flip between syn and anti conformations. Substitution of the same base with 7-deaza-guanine preserves the O6/N1 contacts but still increases the K(d) to 296nM and suggests that it is not simply the loss of affinity that gives rise to the base mobility, but also the stereochemistry of the specific contact to O6. Although these studies provide details of UP1 interactions to nucleic acids, three general observations about RRMs are also evident: (1) as suggested by informatic studies, main-chain to base hydrogen bonding makes up an important aspect of ligand recognition (2) steric clashes generated by modification of a hydrogen bond donor-acceptor pair to a donor-donor pair are poorly tolerated and (3) a conserved lysine position proximal to RNP-2 (K(106)-IFVGGI) orients the purine to allow stereochemical discrimination between adenine and guanine based on the 6-position. This single interaction is well-conserved in known RRM structures and appears to be a broad indicator for purine preference in the larger family of RRM proteins.

-	~~{{STRUCTURE_1u1l\| PDB=1u1l \| SCENE= }}~~	+	Human UP1 as a model for understanding purine recognition in the family of proteins containing the RNA recognition motif (RRM).,Myers JC, Shamoo Y J Mol Biol. 2004 Sep 17;342(3):743-56. PMID:15342234<ref>PMID:15342234</ref>

-	~~===Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG)~~; ~~A Human Telomeric Repeat Containing nebularine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15342234}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[1u1l]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA].~~	+

	==See Also==		==See Also==
	*[[Nucleoprotein\|Nucleoprotein]]		*[[Nucleoprotein\|Nucleoprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015342234<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Myers, J C.]]		[[Category: Myers, J C.]]

OCA at 06:33, 20 October 2012

2012-10-20T06:33:24Z

←Older revision		Revision as of 06:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[1u1l]] is a 2 chain structure ~~of [[Nucleoprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA].	+	[[1u1l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA].

	==See Also==		==See Also==

OCA: Protected "1u1l" [edit=sysop:move=sysop]

2012-07-25T13:33:40Z

Protected "1u1l" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 25 July 2012

OCA at 13:33, 25 July 2012

2012-07-25T13:33:39Z

←Older revision		Revision as of 13:33, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:1u1l.png\|left\|200px]]		[[Image:1u1l.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_1u1l", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_1u1l\| PDB=1u1l \| SCENE= }}		{{STRUCTURE_1u1l\| PDB=1u1l \| SCENE= }}

	===Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine===		===Crystal Structure of UP1 Complexed With d(TTAGGGTT PRN GGG); A Human Telomeric Repeat Containing nebularine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15342234}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15342234 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15342234}}		{{ABSTRACT_PUBMED_15342234}}

	==About this Structure==		==About this Structure==
-	~~1U1L~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA].	+	[[1u1l]] is a 2 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U1L OCA].
		+
		+	==See Also==
		+	*[[Nucleoprotein\|Nucleoprotein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15342234~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015342234</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Myers, J C.]]		[[Category: Myers, J C.]]
Line 35:		Line 26:
	[[Category: Rna recognition motif]]		[[Category: Rna recognition motif]]
	[[Category: Rrm]]		[[Category: Rrm]]
		+	[[Category: Transport protein-dna complex]]
	[[Category: Up1]]		[[Category: Up1]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:37:25 2009''